Login Register Cart 0
Generic placeholder image

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Predictive and Prognostic Value of Ascitic Fluid Mannose Binding Lectin in Patients with Spontaneous Bacterial Peritonitis

Author(s): Amal A. Mohamed, Mohamed Abdelhamid, Naglaa El-Toukhy, Ahmed Sabry, Rania A. Khattab, Dalia Ali El-damasy, Abeer Ahmed, Mahmoud Elkadeem and Sherief Abd-Elsalam*

Volume 20, Issue 2, 2021

Published on: 17 June, 2020

Page: [196 - 200] Pages: 5

DOI: 10.2174/1871523019666200617132513

Price: $65

Abstract

Background: Spontaneous bacterial peritonitis is a common bacterial infection of ascitic fluid, mainly in ascites due to liver cirrhosis. Mannose-binding lectin (MBL) can activate phagocytosis and the complement system. Spontaneous bacterial peritonitis was detected to be higher in MBL deficiency. This study aimed to assess ascitic fluid MBL in liver cirrhosis and spontaneous bacterial peritonitis.

Methods: Ninety patients with cirrhotic ascites were included. Forty five of them had SBP. Child- Pugh score, Model for End Stage Liver Disease (MELD) and its update (uMELD) scores were used to assess the severity of liver cirrhosis. Ascitic fluid samples were obtained for differentiation of leucocytic count, estimation of albumin, protein, glucose, and serum-ascitic albumin gradient. Ascitic fluid levels of MBL were measured for all patients. SBP was documented if polymorphonuclear leucocytic count ≥250/mm in ascitic fluid.

Results: Ascitic fluid MBL level was significantly lower in patients with SBP. MBL had a significant negative correlation with ascitic total leukocytic count (TLC), also with serum creatinine, bilirubin, PT, INR and MELD score among SBP patients. However, it had a significant positive correlation with ascitic protein and with platelets. According to multivariate analysis, fever, TLC, platelets, creatinine, MBL, glucose and polymorphs were independent predictors for SBP development.

Conclusion: Ascitic fluid MBL could be a good predictive and prognostic marker in patients with cirrhosis and spontaneous bacterial peritonitis.

Keywords: Mannose-binding lectin, liver cirrhosis, spontaneous bacterial peritonitis, complement, liver failure, phagocytosis.

« Previous Next »
[1]
Cullaro, G.; Kim, G.; Pereira, M.R.; Brown, R.S., Jr; Verna, E.C. Ascites neutrophil gelatinase-Associated lipocalin identifies spontaneous bacterial peritonitis and predicts mortality in hospitalized patients with cirrhosis. Dig. Dis. Sci., 2017, 62(12), 3487-3494.
[http://dx.doi.org/10.1007/s10620-017-4804-7] [PMID: 29098551]
[2]
Mahmoud, A.B.; Abd El Aziz, A.M.; El Motelb, T.M. Serum level of mannose-binding lectin in cirrhotic patients with spontaneous bacterial peritonitis. Menoufia Med. J., 2017, 30, 984-990.
[http://dx.doi.org/10.4103/1110-2098.229231]
[3]
Wiest, R.; Garcia-Tsao, G. Bacterial translocation (BT) in cirrhosis. Hepatology, 2005, 41(3), 422-433.
[http://dx.doi.org/10.1002/hep.20632] [PMID: 15723320]
[4]
Mikuła, T.; Sapuła, M.; Jabłońska, J.; Kozłowska, J.; Stańczak, W.; Krankowska, D.; Wiercińska-Drapało, A. Significance of heparin-binding protein and D-dimers in the early diagnosis of spontaneous bacterial peritonitis. Mediators Inflamm., 2018.20181969108
[http://dx.doi.org/10.1155/2018/1969108] [PMID: 30363905]
[5]
Ciuca, I.M.; Popescu, I.M.; Lupea, A.X. Mannan binding lectine serum level dosing method REV. CHIM (Bucharest), 2014, 65, 123.
[6]
Dommett, R.M.; Klein, N.; Turner, M.W. Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens, 2006, 68(3), 193-209.
[http://dx.doi.org/10.1111/j.1399-0039.2006.00649.x] [PMID: 16948640]
[7]
Gupta, K.; Gupta, R.K.; Hajela, K. Disease associations of mannose-binding lectin & potential of replacement therapy. Indian J. Med. Res., 2008, 127(5), 431-440.
[PMID: 18653905]
[8]
Pugh, R.N.; Murray-Lyon, I.M.; Dawson, J.L.; Pietroni, M.C.; Williams, R. Transection of the oesophagus for bleeding oesophageal varices. Br. J. Surg., 1973, 60(8), 646-649.
[http://dx.doi.org/10.1002/bjs.1800600817] [PMID: 4541913]
[9]
Kamath, P.S.; Wiesner, R.H.; Malinchoc, M.; Kremers, W.; Therneau, T.M.; Kosberg, C.L.; D’Amico, G.; Dickson, E.R.; Kim, W.R. A model to predict survival in patients with end-stage liver disease. Hepatology, 2001, 33(2), 464-470.
[http://dx.doi.org/10.1053/jhep.2001.22172] [PMID: 11172350]
[10]
Sharma, P.; Schaubel, D.E.; Sima, C.S.; Merion, R.M.; Lok, A.S. Re-weighting the model for end-stage liver disease score components. Gastroenterology, 2008, 135(5), 1575-1581.
[http://dx.doi.org/10.1053/j.gastro.2008.08.004] [PMID: 18835388]
[11]
Badawi, R.; Asghar, M.N.; Abd-Elsalam, S.; Elshweikh, S.A.; Haydara, T.; Alnabawy, S.M.; Elkadeem, M.; ElKhalawany, W.; Soliman, S.; Elkhouly, R.; Soliman, S.; Watany, M.; Khalif, M.; Elfert, A. Amyloid A in serum and ascitic fluid as a novel diagnostic marker of spontaneous bacterial peritonitis. Antiinflamm. Antiallergy Agents Med. Chem., 2019, 19(2), 1. 40-148.
[http://dx.doi.org/10.2174/1871523018666190401154447] [PMID: 30931865]
[12]
Elwan, N.; Salem, M.L.; Kobtan, A.; El-Kalla, F.; Mansour, L.; Yousef, M.; Al-Sabbagh, A.; Zidan, A.A.; Abd-Elsalam, S. High numbers of myeloid derived suppressor cells in peripheral blood and ascitic fluid of cirrhotic and HCC patients. Immunol. Invest., 2018, 47(2), 169-180.
[http://dx.doi.org/10.1080/08820139.2017.1407787] [PMID: 29182438]
[13]
Mohamed, A.A.; El-Toukhy, N.E.R.; Said, E.M.; Gabal, H.M.R.; AbdelAziz, H.; Doss, W.; El-Hanafi, H.; El Deeb, H.H.; Mahmoud, S.; Elkadeem, M.; Shalby, H.S.; Abd-Elsalam, S. Hepatitis C virus: Efficacy of new DAAs Regimens. Infect. Disord. Drug Targets, 2019, 2019(Jan), 20. Epub ahead of print
[http://dx.doi.org/10.2174/1871526519666190121114003] [PMID: 30663575]
[14]
Tandon, P.; Garcia-Tsao, G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin. Liver Dis., 2008, 28(1), 26-42.
[http://dx.doi.org/10.1055/s-2008-1040319] [PMID: 18293275]
[15]
Altorjay, I.; Vitalis, Z.; Tornai, I.; Palatka, K.; Kacska, S.; Farkas, G.; Udvardy, M.; Harsfalvi, J.; Dinya, T.; Orosz, P.; Lombay, B., Jr; Par, G.; Par, A.; Csak, T.; Osztovits, J.; Szalay, F.; Csepregi, A.; Lakatos, P.L.; Papp, M. Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis. J. Hepatol., 2010, 53(3), 484-491.
[http://dx.doi.org/10.1016/j.jhep.2010.03.028] [PMID: 20605050]
[16]
Glargaard, S.; Boysen, T.; Pilely, K.; Garred, P.; Ytting, H. Prognostic value of lectin pathway molecules and complement proteins in ascitic fluid and blood in patients with liver cirrhosis. Scand. J. Gastroenterol., 2018, 53(1), 64-69.
[http://dx.doi.org/10.1080/00365521.2017.1386710] [PMID: 28982257]
[17]
Menshawy, A.; Mattar, O.; Barssoum, K. AboEl-Naga, A.M.; Salim, H.M.; Mohamed, A.M.F.; Elgebaly, A.; Abd-Elsalam, S. Safety and Efficacy of Rifaximin in Prophylaxis of Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-analysis. Curr. Drug Targets, 2019, 20(4), 380-387.
[http://dx.doi.org/10.2174/1389450119666180924145156] [PMID: 30246636]
[18]
Abd-Elsalam, S.; Habba, E.; Elkhalawany, W.; Tawfeek, S.; Elbatea, H.; El-Kalla, F.; Soliman, H.; Soliman, S.; Yousef, M.; Kobtan, A.; El Nawasany, S.; Awny, S.; Amer, I.; Mansour, L.; Rizk, F. Correlation of platelets count with endoscopic findings in a cohort of Egyptian patients with liver cirrhosis. Medicine (Baltimore), 2016, 95(23)e3853
[http://dx.doi.org/10.1097/MD.0000000000003853] [PMID: 27281094]
[19]
Negm, O.; Abou Saif, S.; El Gharib, M.; Yousef, M.; Abd-Elsalam, S. Role of low-molecular-weight heparins in prevention of thromboembolic complication after transarterial chemoembolization in hepatocellular carcinoma. Eur. J. Gastroenterol. Hepatol., 2017, 29(3), 317-321.
[http://dx.doi.org/10.1097/MEG.0000000000000790] [PMID: 27893491]
[20]
Yuen, M.F.; Lau, C.S.; Lau, Y.L.; Wong, W.M.; Cheng, C.C.; Lai, C.L. Mannose binding lectin gene mutations are associated with progression of liver disease in chronic hepatitis B infection. Hepatology, 1999, 29(4), 1248-1251.
[http://dx.doi.org/10.1002/hep.510290417] [PMID: 10094971]

Rights & Permissions Print Cite
Article Metrics
14
2
© 2024 Bentham Science Publishers | Privacy Policy