Login Register Cart 0
Generic placeholder image

当代阿耳茨海默病研究

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe Translate in English
Systematic Review Article

痴呆症中的抑郁症还是抑郁症中的痴呆症？ 对研究和假设的系统评价

卷 17, 期 1, 2020

页: [16 - 28] 页: 13

弟呕挨: 10.2174/1567205017666200217104114

价格: $65

摘要

迄今为止，大多数研究工作表明，重度抑郁症（MDD）是痴呆症的危险因素，可能会导致早期和晚期发作变异的认知能力下降。但是，抑郁症的出现可能并不能反映出原因，而是一种影响：它可能是对认知障碍的反应，或者改变了可能出现或检测到认知障碍的阈值。另一种假设是，抑郁症可能是阿尔茨海默氏病（AD）的一部分，表明存在神经生物学联系，而不仅仅是心理反应之一。遗传多态性可以解释诊断之间共享现象学的某些差异，例如，当条件并发出现时，检测它们的顺序可能取决于个人的认知和身体储备，病史和个人易感性。该假设在生物学上是合理的，但迄今为止尚未进行系统的研究。本综述着重介绍了遗传变异如何参与AD和MDD的发展，以及这些变异对这两种疾病的表达所造成的风险并存，这是未来病原学机制研究和研究样本分层的重要考虑因素用于随机对照试验。

关键词: 阿尔茨海默氏病，抑郁症，痴呆症，危险因素，合并症，常见基因，抗抑郁药。

« Previous Next »
[1]
Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Geneva, Switzerland: World Health Organization. 1996.
[2]
World Health Organization. The top 10 causes of death Fact sheet N°310 2014.
[3]
Holmquist S, Nordström A, Nordström P. The association of depression with subsequent dementia diagnosis: a Swedish nationwide cohort study from 1964 to 2016. PLoS Med 17(1) e1003016 (2020).
[http://dx.doi.org/10.1371/journal.pmed.1003016]
[4]
Bennett S, Thomas AJ. Depression and dementia: cause, consequence or coinci-dence? Maturitas 79(2): 189-90. (2014).
[http://dx.doi.org/10.1016/j.maturitas.2014.05.009]
[5]
Muliyala KP, Varghese M. The complex relationship between depression and dementia. Ann Indian Acad Neurol 13(2): S69-73. (2010).
[http://dx.doi.org/10.4103/0972-2327.74248] [PMID: 21369421]
[6]
Byers AL, Yaffe K. Depression and dementias among military veterans. Alzheimers Dement 10(3): S166-73. (2014).
[http://dx.doi.org/10.1016/j.jalz.2014.04.007] [PMID: 24924668]
[7]
Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, et al. Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice. Mol Psychiatry 18(10): 1053-4. (2013).
[http://dx.doi.org/10.1038/mp.2012.168] [PMID: 23183490]
[8]
Sierksma AS, van den Hove DL, Steinbusch HW, Prickaerts J. Major depression, cognitive dysfunction and Alzheimer’s disease: is there a link? Eur J Pharmacol 626(1): 72-82. (2010).
[http://dx.doi.org/10.1016/j.ejphar.2009.10.021] [PMID: 19837053]
[9]
Santos CSD, Bessa TA, Xavier AJ. Factors associated with dementia in elderly. Cien Saude Colet 25(2): 603-11. (2020).
[http://dx.doi.org/10.1590/1413-81232020252.02042018] [PMID: 32022200]
[10]
Becker JT, Chang YF, Lopez OL, Dew MA, Sweet RA, Barnes D, et al. Depressed mood is not a risk factor for incident dementia in a community-based cohort. Am J Geriatr Psychiatry 17(8): 653-63. (2009).
[http://dx.doi.org/10.1097/JGP.0b013e3181aad1fe] [PMID: 19634208]
[11]
Almeida OP, Hankey GJ, Yeap BB, Golledge J, Flicker L. Depression as a risk factor for cognitive impairment in later life: the Health In Men cohort study. Int J Geriatr Psychiatry 31(4): 412-20. (2016).
[http://dx.doi.org/10.1002/gps.4347] [PMID: 26280254]
[12]
Kuring JK, Mathias JL, Ward L. Prevalence of depression, anxiety and PTSD in people with dementia: a systematic review and meta-Analysis. Neuropsychol Rev 28(4): 393-416. (2018).
[http://dx.doi.org/10.1007/s11065-018-9396-2] [PMID: 30536144]
[13]
Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA 288(12): 1475-83. (2002).
[http://dx.doi.org/10.1001/jama.288.12.1475] [PMID: 12243634]
[14]
Lyketsos CG, Olin J. Depression in Alzheimer’s disease: overview and treatment. Biol Psychiatry 52(3): 243-52. (2002).
[http://dx.doi.org/10.1016/S0006-3223(02)01348-3] [PMID: 12182930]
[15]
Payne JL, Sheppard JM, Steinberg M, Warren A, Baker A, Steele C, et al. Incidence, prevalence, and outcomes of depression in residents of a long-term care facility with dementia. Int J Geriatr Psychiatry 17(3): 247-53. (2002).
[http://dx.doi.org/10.1002/gps.589] [PMID: 11921153]
[16]
Ballard CG, Patel A, Solis M, Lowe K, Wilcock G. A one-year follow-up study of depression in dementia sufferers. Br J Psychiatry 168(3): 287-91. (1996).
[http://dx.doi.org/10.1192/bjp.168.3.287] [PMID: 8833681]
[17]
Andersen K, Lolk A, Kragh-Sørensen P, Petersen NE, Green A. Depression and the risk of Alzheimer disease. Epidemiology 16(2): 233-8. (2005).
[http://dx.doi.org/10.1097/01.ede.0000152116.32580.24] [PMID: 15703539]
[18]
Devanand DP, Sano M, Tang MX, Taylor S, Gurland BJ, Wilder D, et al. Depressed mood and the incidence of Alzheimer’s disease in the elderly living in the community. Arch Gen Psychiatry 53(2): 175-82. (1996).
[http://dx.doi.org/10.1001/archpsyc.1996.01830020093011] [PMID: 8629893]
[19]
Gatz JL, Tyas SL, St John P, Montgomery P. Do depressive symptoms predict Alzheimer’s disease and dementia? J Gerontol A Biol Sci Med Sci 60(6): 744-7. (2005).
[http://dx.doi.org/10.1093/gerona/60.6.744] [PMID: 15983177]
[20]
Köhler S, van Boxtel M, Jolles J, Verhey F. Depressive symptoms and risk for dementia: a 9-year follow-up of the Maastricht Aging Study. Am J Geriatr Psychiatry 19(10): 902-5. (2011).
[http://dx.doi.org/10.1097/JGP.0b013e31821f1b6a] [PMID: 21543967]
[21]
Wilson RS, Arnold SE, Beck TL, Bienias JL, Bennett DA. Change in depressive symptoms during the prodromal phase of Alzheimer disease. Arch Gen Psychiatry 65(4): 439-45. (2008).
[http://dx.doi.org/10.1001/archpsyc.65.4.439] [PMID: 18391132]
[22]
Dotson VM, Beydoun MA, Zonderman AB. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology 75(1): 27-34. (2010).
[http://dx.doi.org/10.1212/WNL.0b013e3181e62124] [PMID: 20603482]
[23]
Kessing LV, Andersen PK. Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? J Neurol Neurosurg Psychiatry 75(12): 1662-6. (2004).
[http://dx.doi.org/10.1136/jnnp.2003.031773] [PMID: 15548477]
[24]
Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology 75(1): 35-41. (2010).
[http://dx.doi.org/10.1212/WNL.0b013e3181e62138] [PMID: 20603483]
[25]
Kaup AR, Byers AL, Falvey C, Simonsick EM, Satterfield S, Ayonayon HN, et al. trajectories of depressive symptoms in older adults and risk of dementia. JAMA Psychiatry 73(5): 525-31. (2016).
[http://dx.doi.org/10.1001/jamapsychiatry.2016.0004] [PMID: 26982217]
[26]
Mossaheb N, Zehetmayer S, Jungwirth S, Weissgram S, Rainer M, Tragl K-H, et al. Are specific symptoms of depression predictive of Alzheimer’s dementia? J Clin Psychiatry 73(7): 1009-15. (2012).
[http://dx.doi.org/10.4088/JCP.11m06962] [PMID: 22687442]
[27]
Steffens DC, Welsh-Bohmer KA, Burke JR, Plassman BL, Beyer JL, Gersing KR, et al. Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study. J Geriatr Psychiatry Neurol 17(4): 202-11. (2004).
[http://dx.doi.org/10.1177/0891988704269819] [PMID: 15533991]
[28]
Tam CW, Lam LC. Association between late-onset depression and incident dementia in Chinese older persons. East Asian Arch Psychiatry 23(4): 154-9. (2013).
[PMID: 24374487]
[29]
Dillon C, Allegri RF, Serrano CM, Iturry M, Salgado P, Glaser FB, et al. Late- versus early-onset geriatric depression in a memory research center. Neuropsychiatr Dis Treat 5: 517-26. (2009).
[http://dx.doi.org/10.2147/NDT.S7320] [PMID: 19851519]
[30]
Li G, Wang LY, Shofer JB, Thompson ML, Peskind EE, McCormick W, et al. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch Gen Psychiatry 68(9): 970-7. (2011).
[http://dx.doi.org/10.1001/archgenpsychiatry.2011.86] [PMID: 21893662]
[31]
Brommelhoff JA, Gatz M, Johansson B, McArdle JJ, Fratiglioni L, Pedersen NL. Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychol Aging 24(2): 373-84. (2009).
[http://dx.doi.org/10.1037/a0015713] [PMID: 19485655]
[32]
Mirza SS, de Bruijn RF, Direk N, Hofman A, Koudstaal PJ, Ikram MA, et al. Depressive symptoms predict incident dementia during short- but not long-term follow-up period. Alzheimers Dement 10(5): S323-S329.e1. (2014).
[http://dx.doi.org/10.1016/j.jalz.2013.10.006]
[33]
Geerlings MI, Schmand B, Braam AW, Jonker C, Bouter LM, van Tilburg W. Depressive symptoms and risk of Alzheimer’s disease in more highly educated older people. J Am Geriatr Soc 48(9): 1092-7. (2000).
[http://dx.doi.org/10.1111/j.1532-5415.2000.tb04785.x] [PMID: 10983909]
[34]
Rovner BW, Casten RJ, Leiby BE. Variability in depressive symptoms predicts cognitive decline in age-related macular degeneration. Am J Geriatr Psychiatry 17(7): 574-81. (2009).
[http://dx.doi.org/10.1097/JGP.0b013e31819a7f46] [PMID: 19554672]
[35]
Heser K, Tebarth F, Wiese B, Eisele M, Bickel H, Köhler M, et al. Age CoDe Study Group. Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). Psychol Med 43(8): 1597-610. (2013).
[http://dx.doi.org/10.1017/S0033291712002449] [PMID: 23137390]
[36]
Brailean A, Aartsen MJ, Muniz-Terrera G, Prince M, Prina AM, Comijs HC, et al. Longitudinal associations between late-life depression dimensions and cognitive functioning: a cross-domain latent growth curve analysis. Psychol Med 47(4): 690-702. (2017).
[http://dx.doi.org/10.1017/S003329171600297X] [PMID: 27834162]
[37]
Migliorelli R, Tesón A, Sabe L, Petracchi M, Leiguarda R, Starkstein SE. Prevalence and correlates of dysthymia and major depression among patients with Alzheimer’s disease. Am J Psychiatry 152(1): 37-44. (1995).
[http://dx.doi.org/10.1176/ajp.152.1.37] [PMID: 7802118]
[38]
Alves L, Simões MR, Martins C, Freitas S, Santana I. Premorbid IQ influence on screening tests’ scores in healthy patients and patients with cognitive impairment. J Geriatr Psychiatry Neurol 26(2): 117-26. (2013).
[http://dx.doi.org/10.1177/0891988713484194] [PMID: 23584853]
[39]
Sánchez JL, Rodríguez M, Carro J. Influence of cognitive reserve on neuropsychologic functioning in Alzheimer’s disease type sporadic in subjects of Spanish nationality. Neuropsychiatry Neuropsychol Behav Neurol 15(2): 113-22. (2002).
[PMID: 12050474]
[40]
Zeki Al Hazzouri A, Vittinghoff E, Byers A, Covinsky K, Blazer D, Diem S, et al. Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women. J Gerontol A Biol Sci Med Sci 69(5): 595-601. (2014).
[http://dx.doi.org/10.1093/gerona/glt139] [PMID: 24097423]
[41]
Sáez-Fonseca JA, Lee L, Walker Z. Long-term outcome of depressive pseudodementia in the elderly. J Affect Disord 101(1-3): 123-9. (2007).
[http://dx.doi.org/10.1016/j.jad.2006.11.004] [PMID: 17184844]
[42]
Butters MA, Becker JT, Nebes RD, Zmuda MD, Mulsant BH, Pollock BG, et al. Changes in cognitive functioning following treatment of late-life depression. Am J Psychiatry 157(12): 1949-54. (2000).
[http://dx.doi.org/10.1176/appi.ajp.157.12.1949] [PMID: 11097959]
[43]
Goveas JS, Hogan PE, Kotchen JM, Jordan W Smoller, Natalie L Denburg, JoAnn E Manson. Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women’s Health Initiative Memory Study. Int Psychogeriatr 24(8): 1252-64. (2012).
[http://dx.doi.org/10.1017/S1041610211002778] [PMID: 22301077]
[44]
Lee CWS, Lin CL, Sung FC, Liang JA, Kao CH. Antidepressant treatment and risk of dementia: a population-based, retrospective case-control study. J Clin Psychiatry 77(1): 117-22. (2016).
[http://dx.doi.org/10.4088/JCP.14m09580] [PMID: 26845268]
[45]
Jacob L, Bohlken J, Kostev K. Risk of dementia in German patients treated with antidepressants in general or psychiatric practices
. Int J Clin Pharmacol Ther 55(4): 322-8. (2017).
[http://dx.doi.org/10.5414/CP202754] [PMID: 28025968]
[46]
Burke SL, Maramaldi P, Cadet T, Kukull W. Decreasing hazards of Alzheimer’s disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33(1): 200-11. (2018).
[http://dx.doi.org/10.1002/gps.4709] [PMID: 28560728]
[47]
Hjelm C, Broström A, Dahl A, Johansson B, Fredrikson M, Strömberg A. Factors associated with increased risk for dementia in individuals age 80 years or older with congestive heart failure. J Cardiovasc Nurs 29(1): 82-90. (2014).
[http://dx.doi.org/10.1097/JCN.0b013e318275543d] [PMID: 23369853]
[48]
Bowirrat A, Oscar-Berman M, Logroscino G. Association of depression with Alzheimer’s disease and vascular dementia in an elderly Arab population of Wadi-Ara, Israel. Int J Geriatr Psychiatry 21(3): 246-51. (2006).
[http://dx.doi.org/10.1002/gps.1455] [PMID: 16477584]
[49]
Adams ML, Grandpre J. Dose-response gradients between a composite measure of six risk factors and cognitive decline and cardiovascular disease. Prev Med 91: 329-34. (2016).
[http://dx.doi.org/10.1016/j.ypmed.2016.09.004] [PMID: 27612576]
[50]
Bell IR, Edman JS, Selhub J, Morrow FD, Marby DW, Kayne HL, et al. Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people. Acta Psychiatr Scand 86(5): 386-90. (1992).
[http://dx.doi.org/10.1111/j.1600-0447.1992.tb03285.x] [PMID: 1485529]
[51]
Reif A, Schneider MF, Kamolz S, Pfuhlmann B. Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patients. J Neural Transm (Vienna) 110(12): 1401-11. (2003).
[http://dx.doi.org/10.1007/s00702-003-0061-3] [PMID: 14666412]
[52]
Kazmierski J, Kloszewska I. Is cortisol the key to the pathogenesis of delirium after coronary artery bypass graft surgery? Crit Care 15: 102. (2011).
[http://dx.doi.org/10.1186/cc9372]
[53]
Ekstrand J, Hellsten J, Tingström A. Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex. Neurosci Lett 442(3): 203-7. (2008).
[http://dx.doi.org/10.1016/j.neulet.2008.06.085] [PMID: 18625288]
[54]
Neubauer AB, Wahl HW, Bickel H. Depressive symptoms as predictor of dementia versus continuous cognitive decline: a 3-year prospective study. Eur J Ageing 10(1): 37-48. (2012).
[http://dx.doi.org/10.1007/s10433-012-0246-4] [PMID: 28804281]
[55]
Zvěřová M, Fišar Z, Jirák R, Kitzlerová E, Hroudová J, Raboch J. Plasma cortisol in Alzheimer’s disease with or without depressive symptoms. Med Sci Monit 19: 681-9. (2013).
[http://dx.doi.org/10.12659/MSM.889110] [PMID: 23955525]
[56]
Kang HJ, Kim JM, Kim SW, Shin II, Park S-W, Kim Y-H, et al. Associations of cytokine genes with Alzheimer’s disease and depression in an elderly Korean population. J Neurol Neurosurg Psychiatry 86(9): 1002-7. (2015).
[http://dx.doi.org/10.1136/jnnp-2014-308469] [PMID: 25315113]
[57]
Matsushima J, Kawashima T, Nabeta H, Imamura Y, Watanabe I, Mizoguchi Y, et al. Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: a 3-year follow-up study. J Affect Disord 173: 9-14. (2015).
[http://dx.doi.org/10.1016/j.jad.2014.10.030] [PMID: 25462389]
[58]
Fountoulakis KN, Kaprinis SG, Iacovides A, Phokas K, Kaprinis G. Are dexamethasone suppression test nonsuppression and thyroid dysfunction related to a family history of dementia in patients with major depression? An exploratory study. Can J Psychiatry 50(6): 342-5. (2005).
[http://dx.doi.org/10.1177/070674370505000609] [PMID: 15999950]
[59]
Chi S, Yu JT, Tan MS. Tan L. Depression in Alzheimer’s disease: epidemiology, mechanisms, and management. J Alzheimers Dis 42(3): 739-55. (2014).
[http://dx.doi.org/10.3233/JAD-140324]
[60]
Reis T, Brandão CO, Freire Coutinho ES, Engelhardt E, Laks J. Cerebrospinal fluid biomarkers in Alzheimer’s disease and geriatric depression: preliminary findings from Brazil. CNS Neurosci Ther 18(7): 524-9. (2012).
[http://dx.doi.org/10.1111/j.1755-5949.2012.00311.x] [PMID: 22530600]
[61]
Kumar A, Kepe V, Barrio JR, Siddarth P, Manoukian V, Elderkin-Thompson V, et al. Protein binding in patients with late-life depression. Arch Gen Psychiatry 68(11): 1143-50. (2011).
[http://dx.doi.org/10.1001/archgenpsychiatry.2011.122] [PMID: 22065530]
[62]
Li P, Hsiao IT, Liu CY, Chen C-H, Huang S-Y, Yen T-C, et al. Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study. EJNMMI Res 7(1): 24. (2017).
[http://dx.doi.org/10.1186/s13550-017-0273-4] [PMID: 28324341]
[63]
Wu KY, Hsiao IT, Chen CS, Chen C-H, Hsieh C-J, Wai Y-Y, et al. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging 41(4): 714-22. (2014).
[http://dx.doi.org/10.1007/s00259-013-2627-0] [PMID: 24233127]
[64]
Pomara N, Doraiswamy PM, Willoughby LM, Roth AE, Mulsant BH, Sidtis JJ, et al. Elevation in plasma Abeta42 in geriatric depression: a pilot study. Neurochem Res 31(3): 341-9. (2006).
[http://dx.doi.org/10.1007/s11064-005-9029-z] [PMID: 16583267]
[65]
Lebedeva A, Westman E, Lebedev AV, Li X, Winblad B, Simmons A, et al. Alzheimer’s disease neuroimaging initiative. structural brain changes associated with depressive symptoms in the elderly with Alzheimer’s disease. J Neurol Neurosurg Psychiatry 85(8): 930-5. (2014).
[http://dx.doi.org/10.1136/jnnp-2013-307110] [PMID: 24421287]
[66]
Ishijima S, Baba H, Maeshima H, Shimano T, Inoue M, Suzuki T, et al. Glucocorticoid may influence amyloid β metabolism in patients with depression. Psychiatry Res 259: 191-6. (2018).
[http://dx.doi.org/10.1016/j.psychres.2017.10.008] [PMID: 29073556]
[67]
Wuwongse S, Cheng SS, Wong GT, Hiu-Ling Hung C, Zhang NQ, Ho Y-S, et al. Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer’s disease. Biochim Biophys Acta 1832(12): 2245-56. (2013).
[http://dx.doi.org/10.1016/j.bbadis.2013.07.022] [PMID: 23928361]
[68]
Metti AL, Cauley JA, Newman AB, Ayonayon HN, Barry LC, Kuller LM, et al. Plasma beta amyloid level and depression in older adults. J Gerontol A Biol Sci Med Sci 68(1): 74-9. (2013).
[http://dx.doi.org/10.1093/gerona/gls093] [PMID: 22499763]
[69]
Sun X, Chiu CC, Liebson E, Crivello NA, Wang L, Claunch J, et al. Depression and plasma amyloid β peptides in the elderly with and without the apolipoprotein E4 allele. Alzheimer Dis Assoc Disord 23(3): 238-44. (2009).
[http://dx.doi.org/10.1097/WAD.0b013e31819cb3ac] [PMID: 19812466]
[70]
Blasko I, Kemmler G, Jungwirth S, Wichart I, Krampla W, Weissgram S, et al. Plasma amyloid beta-42 independently predicts both late-onset depression and Alzheimer disease. Am J Geriatr Psychiatry 18(11): 973-82. (2010).
[http://dx.doi.org/10.1097/JGP.0b013e3181df48be] [PMID: 20808106]
[71]
Wilson RS, Schneider JA, Bienias JL, Arnold SE, Evans DA, Bennett DA. Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons. Neurology 61(8): 1102-7. (2003).
[http://dx.doi.org/10.1212/01.WNL.0000092914.04345.97] [PMID: 14581672]
[72]
Sambataro F, Pennuto M, Christian Wolf R. Catechol-o-methyl transferase modulates cognition in late life: evidence and implications for cognitive enhancement. CNS Neurol Disord Drug Targets 11(3): 195-208. (2012).
[http://dx.doi.org/10.2174/187152712800672463] [PMID: 22483295]
[73]
Vermeiren Y, Van Dam D, Aerts T, Engelborghs S, De Deyn PP. Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease. Neurobiol Aging pii: S0197-4580(4): 00397-2. (2014).
[http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.031]
[74]
Romano A, Pace L, Tempesta B, Lavecchia AM, Macheda T, Bedse G, et al. Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer’s disease. Int J Neuropsychopharmacol 18(4): 020. (2014).
[http://dx.doi.org/10.1093/ijnp/pyu020] [PMID: 25609597]
[75]
Ray MT, Shannon Weickert C, Webster MJ. Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disor-ders Transl Psychiatry 6: 4 e389 (2014).
[http://dx.doi.org/10.1038/tp.2014.26]
[76]
Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease. Prog Neurobiol 63(1): 71-124. (2001).
[http://dx.doi.org/10.1016/S0301-0082(00)00014-9] [PMID: 11040419]
[77]
Tsai SJ, Yeh HL, Hong CJ, Liou Y-J, Yang AC, Liu M-E, et al. Association of CHRNA4 polymorphism with depression and loneliness in elderly males. Genes Brain Behav 11(2): 230-4. (2012).
[http://dx.doi.org/10.1111/j.1601-183X.2011.00741.x] [PMID: 22008229]
[78]
Borroni B, Grassi M, Archetti S, Costanzi C, Bianchi M, Caimi L, et al. BDNF genetic variations increase the risk of Alzheimer’s disease-related depression. J Alzheimers Dis 18(4): 867-75. (2009).
[http://dx.doi.org/10.3233/JAD-2009-1191] [PMID: 19661618]
[79]
Caraci F, Bosco P, Signorelli M, Spada RS, Cosentino FI, Toscano G, et al. The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer’s disease and is associated with AD-related depression. Eur Neuropsychopharmacol 22(4): 281-9. (2012).
[http://dx.doi.org/10.1016/j.euroneuro.2011.08.006] [PMID: 21924590]
[80]
McCulley MC, Day IN, Holmes C. Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet 124B(1): 50-3. (2004).
[http://dx.doi.org/10.1002/ajmg.b.20086] [PMID: 14681913]
[81]
Hamilton G, Evans KL, Macintyre DJ, Deary IJ, Dominiczak A, Smith BH, et al. Alzheimer’s disease risk factor complement receptor 1 is associated with depression. Neurosci Lett 510(1): 6-9. (2012).
[http://dx.doi.org/10.1016/j.neulet.2011.12.059] [PMID: 22244847]
[82]
Skoog I, Waern M, Duberstein P, Blennow K, Zetterberg H, Börjesson-Hanson A. The ace gene is associated with late-life major depression and age at dementia onset in a population-based cohort. Biol Psychiatry 78(10): 730-6. (2015).
[http://dx.doi.org/10.1016/j.biopsych.2015.01.006] [PMID: 25708227]
[83]
Ringman JM, Diaz-Olavarrieta C, Rodriguez Y, Chavez M, Paz F, Murrell J, et al. Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin. J Neurol Neurosurg Psychiatry 75(3): 500-2. (2004).
[http://dx.doi.org/10.1136/jnnp.2002.005025] [PMID: 14966176]
[84]
Ohara K, Suzuki Y, Ohta D, Ohara K. Presenilin-1 in late-onset depressive disorder. Psychiatry Res 95(1): 83-6. (2000).
[http://dx.doi.org/10.1016/S0165-1781(00)00167-0] [PMID: 10904126]
[85]
Sureshkumar R, Bharath S, Jain S, Prakash O, Purushottam M, Thennarasu K, et al. ApoE4 and late onset depression in Indian population. J Affect Disord 136(3): 244-8. (2012).
[http://dx.doi.org/10.1016/j.jad.2011.12.022] [PMID: 22226379]
[86]
Subin Park, Yoon-Young Nam, Yoojin Sim, Jin Pyo Hong. Interactions between the apolipoprotein E ε4 allele status and adverse childhood experiences on depressive symptoms in older adults. Eur J Psychotraumatol 6: 25178. (2015).
[http://dx.doi.org/10.3402/ejpt.v6.25178]
[87]
Tully PJ, Péres K, Berr C, Tzourio C. The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study. Neurobiol Aging 40: 191.e9-191.e10. (2016).
[http://dx.doi.org/10.1016/j.neurobiolaging.2015.12.018] [PMID: 26785975]
[88]
Sun X, Chiu CC, Liebson E, Crivello NA, Wang L, Claunch J, et al. Depression and plasma amyloid beta peptides in the elderly with and without the apolipoprotein E4 allele. Alzheimer Dis Assoc Disord 23(3): 238-44. (2009).
[http://dx.doi.org/10.1097/WAD.0b013e31819cb3ac] [PMID: 19812466]
[89]
Gibson J, Russ TC, Adams MJ, Clarke T-K, Howard DM, Hall LS, et al. Assessing the presence of shared genetic architecture between Alzheimer’s disease and major depressive disorder using genome-wide association data. Transl Psychiatry 7(4) e1094 (2017).
[http://dx.doi.org/10.1038/tp.2017.49] [PMID: 28418403]
[90]
Samieri C, Féart C, Proust-Lima C, Peuchant E, Dartigues J-F, Amieva H, et al. ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression. Neurobiol Aging 32(12) 2317.e13 (2011).
[http://dx.doi.org/10.1016/j.neurobiolaging.2010.03.020] [PMID: 20570406]
[91]
Morgese MG, Schiavone S, Mhillaj E, Bove M, Tucci P, Trabace L. N-3 PUFA diet enrichment prevents amyloid beta-induced depressive-like phenotype. Pharmacol Res 129: 526-34. (2018).
[http://dx.doi.org/10.1016/j.phrs.2017.11.034] [PMID: 29203442]
[92]
Chiu CC, Frangou S, Chang CJ, Chiu W-C, Liu H-C, Sun I-W, et al. Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. Am J Clin Nutr 95(2): 420-7. (2012).
[http://dx.doi.org/10.3945/ajcn.111.015784] [PMID: 22218153]
[93]
Marano CM, Workman CI, Lyman CH, Kramer E, Hermann CR, Ma Y, et al. The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging. Psychiatry Res 222(1-2): 84-90. (2014).
[http://dx.doi.org/10.1016/j.pscychresns.2014.01.009] [PMID: 24650451]
[94]
Guo Z, Liu X, Jia X, Hou H, Cao Y, Wei F, et al. Regional coherence changes in Alzheimer’s disease patients with depressive symptoms: a resting-state functional MRI study. J Alzheimers Dis 48(3): 603-11. (2015).
[http://dx.doi.org/10.3233/JAD-150460] [PMID: 26445159]
[95]
Greenwald BS, Kramer-Ginsberg E, Bogerts B, Ashtari M, Aupperle P, Wu H, et al. Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer’s disease? Psychol Med 27(2): 421-31. (1997).
[http://dx.doi.org/10.1017/S0033291796004576] [PMID: 9089834]
[96]
Steffens DC, Potter GG, McQuoid DR, MacFall JR, Payne ME, Burke JR, et al. Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study. Am J Geriatr Psychiatry 15(10): 839-49. (2007).
[http://dx.doi.org/10.1097/JGP.0b013e318048a1a0] [PMID: 17623814]
[97]
Hickie I, Naismith S, Ward PB, Turner K, Scott E, Mitchell P, et al. Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. Br J Psychiatry 186: 197-202. (2005).
[http://dx.doi.org/10.1192/bjp.186.3.197] [PMID: 15738499]
[98]
Steffens DC, Payne ME, Greenberg DL, Byrum CE, Welsh-Bohmer KA, Wagner HR, et al. Hippocampal volume and incident dementia in geriatric depression. Am J Geriatr Psychiatry 10(1): 62-71. (2002).
[http://dx.doi.org/10.1097/00019442-200201000-00008] [PMID: 11790636]
[99]
Elcombe EL, Lagopoulos J, Duffy SL, Lewis SJG, Norrie L, Hickie IB, et al. Hippocampal volume in older adults at risk of cognitive decline: the role of sleep, vascular risk, and depression. J Alzheimers Dis 44(4): 1279-90. (2015).
[http://dx.doi.org/10.3233/JAD-142016] [PMID: 25408219]
[100]
Avila R, Ribeiz S, Duran FL, Arrais JPJ, Moscoso MAA, Bezerra DM, et al. Effect of temporal lobe structure volume on memory in elderly depressed patients. Neurobiol Aging 32(10): 1857-67. (2011).
[http://dx.doi.org/10.1016/j.neurobiolaging.2009.11.004] [PMID: 20031272]
[101]
Lopez OL, Becker JT, Sweet RA, Martin-Sanchez FJ, Hamilton RL. Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease. Neurology 67(4): 660-5. (2006).
[http://dx.doi.org/10.1212/01.wnl.0000230161.28299.3c] [PMID: 16924019]
[102]
Förstl H, Burns A, Luthert P, Cairns N, Lantos P, Levy R. Clinical and neuropathological correlates of depression in Alzheimer’s disease. Psychol Med 22(4): 877-84. (1992).
[http://dx.doi.org/10.1017/S0033291700038459] [PMID: 1488485]
[103]
Karavasilis E, Parthimos TP, Papatriantafyllou JD, Papageorgiou SG, Kapsas G, Papanicolaou AC, et al. A specific pattern of gray matter atrophy in Alzheimer’s disease with depression. J Neurol 264(10): 2101-9. (2017).
[http://dx.doi.org/10.1007/s00415-017-8603-z] [PMID: 28856425]
[104]
Lim HK, Jung WS, Ahn KJ, Won WY, Hahn C, Lee SY, et al. Regional cortical thickness and subcortical volume changes are associated with cognitive impairments in the drug-naive patients with late-onset depression. Neuropsychopharmacology 37(3): 838-49. (2012).
[http://dx.doi.org/10.1038/npp.2011.264]
[105]
Tully PJ, Debette S, Mazoyer B, Tzourio C. White matter lesions are associated with specific depressive symptom trajectories among incident depression and dementia populations: three-city dijon mri study. Am J Geriatr Psychiatry 25(12): 1311-21. (2017).
[http://dx.doi.org/10.1016/j.jagp.2017.06.003] [PMID: 28688824]
[106]
Miller DS, Kumar A, Yousem DM, Gottlieb GL. MRI High-intensity signals in late-life depression and alzheimer’s disease: a comparison of subjects without major vascular risk factors. Am J Geriatr Psychiatry 2(4): 332-7. (1994).
[http://dx.doi.org/10.1097/00019442-199402040-00008] [PMID: 28530983]
[107]
Xia M, Yang L, Sun G, Qi S, Li B. Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system. Psychopharmacology (Berl) 234(3): 365-79. (2017).
[http://dx.doi.org/10.1007/s00213-016-4473-9] [PMID: 27837334]

Rights & Permissions Print Cite
Article Metrics
251
8
1
© 2024 Bentham Science Publishers | Privacy Policy