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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Mini-Review Article

Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule

Author(s): Hongwei Si*, Chao-Qiang Lai* and Dongmin Liu*

Volume 28, Issue 1, 2021

Published on: 30 December, 2019

Page: [3 - 18] Pages: 16

DOI: 10.2174/0929867327666191230104958

Price: $65

Abstract

Epicatechin (EC), a flavonoid present in various foods including cocoa, dark chocolate, berries, and tea, has recently been reported to promote general health and survival of old mice fed a standard chow diet. This is considered a novel discovery in the field of identifying natural compounds to extend lifespan, given that presumably popular anti-aging natural agents including resveratrol, green tea extract, and curcumin had failed in extending the lifespan of standard chow-diet-fed mice. However, the anti-aging mechanism of EC is not fully understood, thus impeding the potential application of this natural compound in improving a healthy lifespan in humans. In this review, we first summarized the main dietary sources that contain a significant amount of EC and recent research regarding the absorption, metabolism and distribution of EC in humans and rodents. The review is then focused on the anti-aging effects of EC in cultured cells, animals and humans with the possible physiological, cellular and molecular mechanisms underlying its lifespan-extending effects.

Keywords: Epicatechin, dietary intake, lifespan, anti-aging, animals, humans, EC, Bioactive molecule.

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