[1]
Nelson PT, Smith CD, Abner EA, Schmitt FA, Scheff SW, Davis GJ, et al. Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta Mol Basis Dis 1792(5): 454-69. (2009)
[2]
Whitsell LJ, Francisco S. Neurologic complications of diabetes. Calif Med 96(1): 14-20. (1962)
[3]
Ola MS, Ahmed MM, Shams S, Al-Rejaie SS. Neuroprotective effects of quercetin in diabetic rat retina. Saudi J Biol Sci 24(6): 1186-94. (2017)
[4]
Ahmed R, Ramayya PJ, Raju NKB, Kumar RVS, Rao SD. Microscopic studies on islets of langerhans of pancreas of adult albino rat. Indian J Vet Anat 26(2): 9-98. (2014)
[6]
Meduru H, Wang Y-T, Tsai JJP, Chen Y-C. Finding a potential dipeptidyl peptidase-4 (dpp-4) inhibitor for type-2 diabetes treatment based on molecular docking, pharmacophore generation, and molecular dynamics simulation. Int J Mol Sci 17(6): 1-12. (2016)
[7]
Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract 60(11): 1454-70. (2006)
[8]
Femminella GD, Bencivenga L, Petraglia L, Visaggi L, Gioia L, Grieco FV, et al. Antidiabetic Drugs in Alzheimer’s disease : mechanisms of action and future perspectives. J Diabetes Res 2017: 1-7. (2017)
[9]
Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, et al. The link between type 2 diabetes and neurodegeneration: roles for amyloid-β, amylin, and tau proteins. J Alzheimers Dis 59(2): 421-32. (2017)
[10]
Choon Sang Bae and Juhyun Song.The role of glucagon-like peptide 1 (GLP1) in type 3 diabetes: glp-1 controls insulin resistance, neuroinflammation and neurogenesis in the brain choon. Int J Mol Sci 18: 1-7. (2017)
[11]
Moran C, Beare R, Bruce DG, Callisaya ML. Type 2 diabetes mellitus and biomarkers of neurodegeneration. Neurology 85: 1123-30. (2015)
[12]
Gupta V, Kalra S. Choosing a Gliptin. Indian J Endocrinol Metab 15(4): 298-308. (2011)
[13]
Charbonnel B, Karasik A, Liu J, Wu M, Meininger G. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 29(12): 2638-43. (2006)
[14]
Bhuvanendran S, Hanapi NA, Ahemad N, Othman I, Yusof SR, Shaikh MF. Embelin, a potent molecule for Alzheimer’s disease: a proof of concept from blood-brain barrier permeability, acetylcholinesterase inhibition and molecular docking studies. Front Neurosci 13(MAY): 1-10. (2019)
[15]
During MJ, Cao L, Zuzga DV, et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9(9): 1173-9. (2003)
[16]
Roh E, Song DK, Kim MS. Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Exp Mol Med 48(3)e216 (2016)
[17]
Jain S, Sharma B. Neuroprotective effect of selective DPP-4 inhibitor in experimental vascular dementia. Physiol Behav 152: 182-93. (2015)
[18]
Umegaki H. Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration? Age Ageing 39(1): 8-10. (2010)
[19]
Zengin G, Locatelli M, Stefanucci A, Macedonio G, Novellino E, Mirzaie S, et al. Chemical characterization, antioxidant properties, anti-inflammatory activity, and enzyme inhibition of Ipomoea batatas L. leaf extracts. Int J Food Prop 20(2): 1907-19. (2017)
[20]
Liu Y. Singh Dhurendra, Nair MG. Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties. J Funct Foods 4: 116-21. (2012)
[21]
Janbaz KH, Haider S, Imran I, Zia-Ul-Haq M, De Martino L, De Feo V. Pharmacological evaluation of prosopis cineraria (L.) Druce in gastrointestinal, respiratory, and vascular disorders. Evidence-based Complement Altern Med 2012: 1-7. (2012)
[22]
Zhu ZJ, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, et al. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nat Protoc 8(3): 451-60. (2013)
[23]
Quaye O, Cramer P, Ofosuhene M, Okine LKN, Nyarko AK. Acute and Subchronic toxicity studies of aqueous extract of desmodium adscendens (SW) dc. J Evidence-Based Complement Altern Med 22(4): 753-9. (2017)
[24]
Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7(2): 88-95. (1961)
[25]
Okello EJ, Savelev SU, Perry EK. In vitro anti-β-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia. Phytother Res 18(8): 624-7. (2004)
[26]
Kumar Shivani. Chatterjee Sayan KS. Dual anti-cholinesterase activity of ajoene by in silico and in vitro studies. Pharmacognosy Res 24-30. (2018)
[27]
Guasch L, Ojeda MJ, Gonzez-Abu N, Sala E, Cereto-Massagu A, Mulero M, et al. Identification of Novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part I): virtual screening and activity assays. PLoS One 7(9)e44971 (2012)
[28]
Nongonierma AB, FitzGerald RJ. Dipeptidyl peptidase IV inhibitory properties of a whey protein hydrolysate: Influence of fractionation, stability to simulated gastrointestinal digestion and food-drug interaction. Int Dairy J 32(1): 33-9. (2013)
[29]
Mogana R, Teng-Jin K, Wiart C. Anti-inflammatory, anticholinesterase, and antioxidant potential of scopoletin isolated from Canarium patentinervium Miq. (Burseraceae Kunth). Evidence-based Complement Altern Med 2013: 1-7. (2013)
[30]
M. Kergoat DB and BP. Effect of high sucrose diet on insulin secretion and insulin action. A study in rats with non-insulin-dependent diabetes induced by streptozotocin. Diabetologia 30: 666-73. (1987)
[31]
Parmar HS, Jain P, Chauhan DS, Bhinchar MK, Munjal V, Yusuf M, et al. DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. Diabetes Res Clin Pract 97(1): 105-11. (2012)
[32]
Ribeiro RT, Lautt WW, Legare DJ, Macedo MP. Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves. Diabetologia 48(5): 976-83. (2005)
[33]
Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 13(9-10): 624-9. (2006)
[34]
Şen S, Çelık S. The effect of acetylsalicylic acid on vasopressin, serum insulin levels, insulin resistance, and biochemical parameters in rats induced with experimental diabetes type 2. Turk J Med Sci 47(3): 996-01. (2017)
[35]
Ram H, Jatwa R, Purohit A. Antiatherosclerotic and cardioprotective potential of acacia senegal seeds in diet-induced atherosclerosis in rabbits. Biochem Res Int 2014: 1-6. (2014)
[36]
Ram H, Purohit A, Ram H. Hypolipidemic and antiatherosclerotic effects of Prosopis cineraria bark extract in experimentally induced hyperlipidemic rabbits. Asian J Pharm Clin Res 5: 106-9. (2016)
[37]
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7): 412-9. (1985)
[38]
Cersosimo E, Solis-Herrera C, Trautmann ME, Malloy J, Triplitt CL. Assessment of pancreatic beta-cell function: review of methods and clinical applications. Curr Diabetes Rev 10: 2-42. (2014)
[39]
Hadi MA, Zaidan HK, Hmood A, Saadi A. Histopathological changes of pancreatic tissues in hyperglycemic male rats treated with mixture of plants extracts. Int J Chemtech Res 9(06): 501-13. (2016)
[40]
Morris GM, Ruth H, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, et al. Software news and updates AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem 30(16): 2785-91. (2009)
[41]
Kaur J, Singla R, Jaitak V. In silico study of flavonoids as DPP-4 and α-glucosidase inhibitors. Lett Drug Des Discov 15(6): 1-9. (2018)
[43]
Jae Lee H. In Seo H, Yun Cha H, Jung Yang Y, Hyun Kwon S, Jin Yang S. Diabetes and Alzheimer’s disease: mechanisms and nutritional aspects. Clin Nutr Res 7(4): 229-40. (2018)
[44]
Ezcurra M, Reimann F, Gribble FM, Emery E. Molecular mechanisms of incretin hormone secretion. Curr Opin Pharmacol 13(6): 922-7. (2013)
[45]
Kumar S, Seal CJ, Howes MJR, Kite GC, Okello EJ. In vitro protective effects of Withania somnifera (L.) Dunal root extract against hydrogen peroxide and beta-amyloid(1-42)-induced cytotoxicity in differentiated PC12 cells. Phytother Res 24(10): 1567-74. (2010)
[46]
Zhao M, Chen J, Yuan Y, Zou Z, Lai X, Rahmani DM, et al. Dipeptidyl peptidase-4 inhibitors and cancer risk in patients with type 2 diabetes: a meta-analysis of randomized clinical trials. Sci Rep 7(1): 8273. (2017)
[47]
Paliwal S, Seth D, Yadav D, Yadav R, Paliwal S. Development of a robust QSAR model to predict the affinity of pyrrolidine analogs for dipeptidyl peptidase IV (DPP-IV). J Enzyme Inhib Med Chem 26(1): 129-40. (2011)
[48]
Yadav E, Singh D, Yadav P, Verma A. Comparative evaluation of Prosopis cineraria (L.) druce and its ZnO nanoparticles on scopolamine induced amnesia. Front Pharmacol 9(5): 1-18. (2018)
[49]
Karagiannis T, Boura P, Tsapas A, Thomas Karagiannis PB. and AT, Karagiannis T, Boura P, et al.Safety of dipeptidyl peptidase 4 inhibitors: a perspective review. Ther Adv Drug Saf 5(3): 138-46. (2014)
[50]
Hundal R, Krssak M, Dufour S, Laurent D. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49(12): 2063-9. (2000)
[51]
Chang CLT, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Alternat Med 2013378657 (2013)
[52]
Kornelius E, Lin CL, Chang HH, Li HH, Huang WN, Yang YS, et al. DPP-4 Inhibitor linagliptin attenuates Aβ-induced cytotoxicity through activation of AMPK in neuronal cells. CNS Neurosci Ther 21(7): 549-57. (2015)
[53]
Singh R, Bhat GA, Sharma P. GLP-1 secretagogues potential of medicinal plants in management of diabetes. J Pharmacognosy Phytochem 4(1): 197-02. (2015)
[54]
Meneilly GS, McIntosh CHS, Pederson RA, Habener JF, Ehlers MRW, Egan JM, et al. Effect of glucagon-like peptide 1 (7-36 Amide) on insulin-mediated glucose uptake in patients with type 1 diabetes. Diabetes Care 26(3): 837-42. (2003)
[55]
Chatzigeorgiou A, Halapas A, Kalafatakis K, Kamper E. The use of animal models in the study of diabetes mellitus. In Vivo 23(2): 245-58. (2009)
[56]
Brubaker PL, Drucker DJ. Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 145(6): 2653-9. (2004)
[57]
Mollica A, Zengin G, Locatelli M, Stefanucci A, Mocan A, Macedonio G, et al. Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L: in vivo and in vitro evaluation of its nutraceutical potential. J Funct Foods 35: 32-42. (2017)
[58]
Colovic MB, Krstic DZ, Lazarevic-Pasti TD, Bondzic AM, Vasic VM. Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol 11(3): 315-35. (2013)
[59]
Blomme EAG, Will Y. Toxicology strategies for drug discovery: present and future. Chem Res Toxicol 29(4): 473-504. (2016)
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