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Review Article

抗阿尔茨海默氏症药物研究中的糖尿病理论-第1部分：抗糖尿病药的治疗潜力

卷 27, 期 39, 2020

页: [6658 - 6681] 页: 24

弟呕挨: 10.2174/0929867326666191011144818

价格: $65

摘要

阿尔茨海默氏病（AD）是一种慢性进行性神经退行性疾病，全世界有4600万人受到影响。它的特点是认知能力下降，包括记忆和思维能力。 AD患者还患有痴呆的行为和心理症状，其中抑郁症最普遍。目前可用的药物可提供适度的症状缓解，并且不能减轻病理特征（老年斑和神经原纤维缠结）和神经炎症，这两者都是AD的组成部分。研究表明，AD是一种表现在大脑中的糖尿病。尽管AD和糖尿病目前被分类为单独的疾病实体，但是它们具有共同的病理生理机制，其中之一是参与炎症以及调节代谢，再生和神经过程的细胞因子水平升高。这篇综述的目的是更新有关抗糖尿病药的发现和开发的最新报告，这些药物是用于对症和疾病缓解性治疗的有前途的药物。我们收集了体外和体内研究的结果，最近的临床试验报告表明抗糖尿病药在AD记忆增强疗法中的实用性。还介绍了它们对慢性神经发炎，病理学特征和认知缺陷共同引起的神经精神症状的有益作用。抗糖尿病药是指AD的糖尿病和炎症假设，并为寻找一种有效的药物来对该疾病进行综合治疗提供了希望。

关键词: 阿尔茨海默氏病，BPSD，认知障碍，神经退行性疾病，神经炎症，III型糖尿病，抗糖尿病药，抗炎活性。

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