Frontiers in Bioactive Compounds

Volume: 1

Recent Advances in the Analysis of Bioactive Compounds Based on Molecular Recognition

Author(s): Robert Săndulescu, Cecilia Cristea, Ede Bodoki and Radu Oprean

Pp: 69-126 (58)

DOI: 10.2174/9781681083414116010006

* (Excluding Mailing and Handling)

Abstract

Most of the biological processes, either normal or pathological, are based on molecular recognition. Molecular recognition, defined as the ability of one molecule (host) to “recognize” another molecule (guest), which presents complementarity, mainly through bonding interactions and molecular geometry, may be exploited in the analytical sciences, as long as the specific interaction produces a detectable change that can be measured by an instrument. The most impactful and acknowledged analytical use of molecular recognition has been recorded in separation sciences, namely in solid phase extraction and affinity chromatographic applications, but also in optical and electrochemical chemo- and biosensing. In living organisms the molecular recognition system is represented by natural receptors, characterized by the highest affinity and specificity, being the natural targets for toxins and mediators of physiological processes. By consequence, a large variety of bioelements, such enzymes, antibodies, nucleic acids, and cells were investigated in the last decades, being integrated in various separation and sensing devices which were successfully applied in biomedical and environmental analyses or monitoring. However, their isolation, purification, stability and cost are critical issues. Therefore, the development of artificial biomimetic receptors, such as cyclodextrins and derivatives, calixarenes, ligands (valinomycine, crown-ethers, etc.), aptamers, and molecularly imprinted polymers focused the attention of many research groups. The most recent achievements in the field of analytical sciences based on molecular recognition, such as separation techniques (solid phase extraction, chromatography, electrophoresis), and sensing (electrochemical, optical, etc.) are revised.


Keywords: Antibodies, Aptamers, Biomimetic receptors, Calixarenes, Chiral discrimination, Cyclodextrins, DNA, Electrochemical sensors and biosensors, Guest-host interaction, Molecular recognition, Molecularly imprinted polymers, Separation methods.

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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739835019 and j.to_date >= 1739835019 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 9632) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739835019 and j.to_date >= 1739835019 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 9632) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739835019 and j.to_date >= 1739835019 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 9632)
      620μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1966 and `b`.`banner_from_date` <= 1739835019 and `b`.`banner_to_date` >= 1739835019 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.06msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1966
      • 3: 1739835019
      • 4: 1739835019
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='2b0855ab220b16f1d54b0e08aff78fd1'
      280μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    12Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        wyOystid2ZYVkLiVmjT1khVyI4Jc7k8ua7GauRuC
        uc_cart_id
        2b0855ab220b16f1d54b0e08aff78fd1
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/9632" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/9632
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Imkrb2NhOEZMUHlmRUhrRks0RGdNRFE9PSIsInZhbHVlIjoiRFJYTURCL3U4R1ZhQUxtNEcwWWdtSGpRYTYwdHd3ZlBnd1pGVnlXRG5pQWdOOXhhZXVDOUQ5RkxZWCtjWDR6MSIsIm1hYyI6IjRjZjczNDExOTJlOTI1NjhjZDM3OWZjYmRiNTg4NzM3ZWU5Nzg3MmJlZjIwNzgxN2I4NDExYjFkNDIyMDI5ODkiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6IkdkeFBxZUNjbDlON21VN3RDdUpuSlE9PSIsInZhbHVlIjoiSzJwczQ3UklURGlncUJCanJsS0trZFNGNU4zOXR3VG9jZC9lUC9GSVBaOS9vVVBEQUJjTGRWcGMzaHg2RHdVNTFOVmxabG5vM2gxVEd3TTUxeEF6T3A3MjdRb3BhSUhwdTkzN3ZzaDgydFVtUXVEc3FwekgzdWswYmFiMU1pdWciLCJtYWMiOiIxOGE3YWQ2YTllZmVmZmVkNTUwODViYTM1YmVmYWQ1NjRiNWEwNDNkZDJhMjYwODhjNGIwMTVkYWUxNmRmMWRjIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6InlTQkZiLzNyYUU3aFJQSERnSzVPV3c9PSIsInZhbHVlIjoiNXZRZVNKb0tkMXc2SXo5N0ZEVjZWSGwzRm92VGxQQ29SVmpNY1JBejZmeWJ1Wk1oeTBoRmoweW50WmUyMzl4ODJyazhiaUFwR2ZvdW5YTm1sTElOUXQ4WVRJUFg1YUszUzUvbmZiN2FDN0NtR2k1czlWWkEyUHdENzJLbzJrM08iLCJtYWMiOiI0MGE3NTYwNjg1YTE0ZjZiOGRiYTk2ZmE5YzVhNmQ5MTg1ZjJmNzgxNzQwOWZkMjlhMDVhNDI1YTNmOWQzNGUzIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Imkrb2NhOEZMUHlmRUhrRks0RGdNRFE9PSIsInZhbHVlIjoiRFJYTURCL3U4R1ZhQUxtNEcwWWdtSGpRYTYwdHd3ZlBnd1pGVnlXRG5pQWdOOXhhZXVDOUQ5RkxZWCtjWDR6MSIs" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "wyOystid2ZYVkLiVmjT1khVyI4Jc7k8ua7GauRuC" "uc_cart_id" => "2b0855ab220b16f1d54b0e08aff78fd1" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/9632" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:30:19GET/chapter/96321121914