Frontiers in Drug Design and Discovery

Volume: 7

Metabolic Pathways and Chemotherapy Drugs

Author(s): Mahbuba Rahman

Pp: 3-35 (33)

DOI: 10.2174/9781681081656116070003

* (Excluding Mailing and Handling)

Abstract

Chemotherapy drugs are long being used to treat cancer either as single drug or in combination with other treatment strategies. However, the current problem with treatment is the development of chemo-resistance properties of cancer cells that causes relapses at the later stages of the treatment. It is therefore necessary to design and develop new drugs or modify existing treatment strategies. Cancer cells show abnormal cell growth and adopt metabolic pathways that are different from normal cells. There are also links between metabolic pathways and chemo-resistance development in cancer cells. This indicates the importance of integration of knowledge on the metabolic pathways of cancer cells prior to new drug design and development for cancer treatment. In this review, we discuss the metabolic pathways associated with chemo-resistance development and focus on existing or new drugs targeting these pathways.


Keywords: Antimetabolites, Autophagy, Chemotherapy drugs, Chemoresistance, Drug design and Development, Metabolic pathways, Regulatory proteins, Signalling molecules, Systems biology.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version243msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[21:54:02] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (145ms)time
  • Application (98.72ms)time
  • 1 x Booting (59.41%)
    145ms
    1 x Application (40.59%)
    98.72ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed27.05ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51594075','',1,1740347642,1740347642) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740347642
      1.09msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51594075','/chapter/8950',1,1740347642,1740347642)
      200μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51594075 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51594075) limit 1
      14.94msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51594075
      • 1: 51594075
      • 2: 51594075
      • 3: 51594075
      • 4: 51594075
      • 5: 51594075
      • 6: 51594075
      • 7: 51594075
      • 8: 51594075
      • 9: 51594075
      • 10: 51594075
      • 11: 51594075
      • 12: 51594075
      • 13: 51594075
      • 14: 51594075
      • 15: 51594075
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '8950' limit 1
      270μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 8950
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '8950' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.12msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 8950
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '8950'
      1.22msalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 8950
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 151 limit 1
      280μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 151
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=151) and se.ebook_id!=151 and v.ebook_status='1'
      1.15msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=151) and se.ebook_id!=151 and v.ebook_status='1' limit 10 offset 0
      1.01msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=151)
      520μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=151) limit 10 offset 0
      580μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 1951 and `e`.`is_uploaded` = 1
      730μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 1951
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 151 and ebook_volume_id <> 1951 limit 1
      350μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 151
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '8950' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      390μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1951' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51594075 and j.to_ip >=51594075 )) and ((j.from_date <= 1740347642 and j.to_date >= 1740347642 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1951) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51594075 and j.to_ip >=51594075 )) and ((j.from_date <= 1740347642 and j.to_date >= 1740347642 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1951) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51594075 and j.to_ip >=51594075 )) and ((j.from_date <= 1740347642 and j.to_date >= 1740347642 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1951)
      780μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51594075 and j.to_ip >=51594075 )) and ((j.from_date <= 1740347642 and j.to_date >= 1740347642 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8950) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51594075 and j.to_ip >=51594075 )) and ((j.from_date <= 1740347642 and j.to_date >= 1740347642 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8950) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51594075 and j.to_ip >=51594075 )) and ((j.from_date <= 1740347642 and j.to_date >= 1740347642 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8950)
      770μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1951 and `b`.`banner_from_date` <= 1740347642 and `b`.`banner_to_date` >= 1740347642 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1951
      • 3: 1740347642
      • 4: 1740347642
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='c08b6ec4d26b93d1b6b28a1cbe2b35b8'
      200μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    9Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        p53zwO40VKtWZIqhdb4Zce3JtuKH50Q9AfrES2Nr
        uc_cart_id
        c08b6ec4d26b93d1b6b28a1cbe2b35b8
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/8950" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/8950
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IkxaK3Yvc2hkbjJjSkVUeXpuVUE4enc9PSIsInZhbHVlIjoibG05TUNOdndwaUFaeW9NMDcxLy83SThlS0xjN0pSL3QvRjcvL09oT09JOD0iLCJtYWMiOiIyYjY4ZjdiYWJjMzc1OTQ3YjkyODk0OWY1OWI1MGU2YjZjNTgzYjY4NWM4YmM5ZTUzNTEyY2I3YThjMWIwNWJlIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IkxaK3Yvc2hkbjJjSkVUeXpuVUE4enc9PSIsInZhbHVlIjoibG05TUNOdndwaUFaeW9NMDcxLy83SThlS0xjN0pSL3QvRjcvL09oT09JOD0iLCJtYWMiOiIyYjY4ZjdiYWJjMzc1" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:54:02 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlUxWit3bEx5NjdqTyttYXAyWW8xUmc9PSIsInZhbHVlIjoiNXNDMnc4YW5nbHRTbGNlUWQveEpTVmRETC9EQ0NwMTl3NlZaVUF1TlR6MWpXMldNWUdhQWpURWFMU083L3k2ZEFVcUUvQ2c1c084RlI4MkgzNFR0d3dLZmlHYVh4TXJJRms3Y1NXbW93NS8xSnorMklEbDR1dUhETzFkeEE5SEMiLCJtYWMiOiJhM2IxOTdjMjk0NWUxM2E5YTBkZjdkZTFlYzVlMTgxOWE5NjBmYjliZWUyNDU4MWFhNTgxMTc2ZGY4NTY4MWIxIiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:54:02 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IlUxWit3bEx5NjdqTyttYXAyWW8xUmc9PSIsInZhbHVlIjoiNXNDMnc4YW5nbHRTbGNlUWQveEpTVmRETC9EQ0NwMTl3NlZaVUF1TlR6MWpXMldNWUdhQWpURWFMU083L3k2ZEFVcUUvQ" 1 => "alphaeurekaselectnet_session=eyJpdiI6InpJaXA5alArcjVHRHU3N0k3OTd0UlE9PSIsInZhbHVlIjoiZkRteHk5RFBrNEZBdGhNWlI3eFU5TFZKSlVtLzdHYkVHb2VSbUVnalpjNWJCUU00dDRyeW9TamFBdFdtRzA2TWVRNjNBeGxQaUVmYU90WEx3WkkvZ282bE5OWWw1S0gzZ0NRdVlYU2F4K1RtTmlLYW82UFRJa3M1OGxORmZZQTQiLCJtYWMiOiIzNDU4MDg0YzliNDI3OTNkNzZmN2U1ZDVjMzVlMjlhZDAzNGZkMmM1NDFhZWYxZWY4ZmI0M2UyZmE0NDQ5N2JjIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InpJaXA5alArcjVHRHU3N0k3OTd0UlE9PSIsInZhbHVlIjoiZkRteHk5RFBrNEZBdGhNWlI3eFU5TFZKSlVtLzdHYkVHb2VSbUVnalpjNWJCUU00dDRyeW9TamF" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlUxWit3bEx5NjdqTyttYXAyWW8xUmc9PSIsInZhbHVlIjoiNXNDMnc4YW5nbHRTbGNlUWQveEpTVmRETC9EQ0NwMTl3NlZaVUF1TlR6MWpXMldNWUdhQWpURWFMU083L3k2ZEFVcUUvQ2c1c084RlI4MkgzNFR0d3dLZmlHYVh4TXJJRms3Y1NXbW93NS8xSnorMklEbDR1dUhETzFkeEE5SEMiLCJtYWMiOiJhM2IxOTdjMjk0NWUxM2E5YTBkZjdkZTFlYzVlMTgxOWE5NjBmYjliZWUyNDU4MWFhNTgxMTc2ZGY4NTY4MWIxIiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:54:02 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IlUxWit3bEx5NjdqTyttYXAyWW8xUmc9PSIsInZhbHVlIjoiNXNDMnc4YW5nbHRTbGNlUWQveEpTVmRETC9EQ0NwMTl3NlZaVUF1TlR6MWpXMldNWUdhQWpURWFMU083L3k2ZEFVcUUvQ" 1 => "alphaeurekaselectnet_session=eyJpdiI6InpJaXA5alArcjVHRHU3N0k3OTd0UlE9PSIsInZhbHVlIjoiZkRteHk5RFBrNEZBdGhNWlI3eFU5TFZKSlVtLzdHYkVHb2VSbUVnalpjNWJCUU00dDRyeW9TamFBdFdtRzA2TWVRNjNBeGxQaUVmYU90WEx3WkkvZ282bE5OWWw1S0gzZ0NRdVlYU2F4K1RtTmlLYW82UFRJa3M1OGxORmZZQTQiLCJtYWMiOiIzNDU4MDg0YzliNDI3OTNkNzZmN2U1ZDVjMzVlMjlhZDAzNGZkMmM1NDFhZWYxZWY4ZmI0M2UyZmE0NDQ5N2JjIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InpJaXA5alArcjVHRHU3N0k3OTd0UlE9PSIsInZhbHVlIjoiZkRteHk5RFBrNEZBdGhNWlI3eFU5TFZKSlVtLzdHYkVHb2VSbUVnalpjNWJCUU00dDRyeW9TamF" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "p53zwO40VKtWZIqhdb4Zce3JtuKH50Q9AfrES2Nr" "uc_cart_id" => "c08b6ec4d26b93d1b6b28a1cbe2b35b8" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/8950" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:54:02GET/chapter/89501121911