Abstract
The liver is an essential organ involved in elimination of drugs and toxins. Any drug, including herbal remedies or dietary supplements, can be a causative agent for drug-induced liver injury (DILI). An aging society or requirement for advanced medical care with multiple medications may complicate the management of DILI, especially in developed countries. The possibility of developing DILI should always be considered when starting new drugs. The classification of DILI—hepatocellular, cholestatic, or mixed—is useful for management. Discontinuation of the causative drug is usually sufficient to manage patients with DILI, but liver injury may persist or progress even after the drug has been stopped, especially in cholestatic type DILI.
Keywords: Causality assessment, DILI, liver function, Toxic liver injury.
About this chapter
Cite this chapter as:
Kazuto Tajiri, Yukihiro Shimizu ;Approach to Liver Injury Caused by Drugs and Toxins, Comprehensive Practical Hepatology (2016) 1: 177. https://doi.org/10.2174/9781681082059116010012
DOI https://doi.org/10.2174/9781681082059116010012 |
Publisher Name Bentham Science Publisher |