Frontiers in Anti-Cancer Drug Discovery

Volume: 6

Use of Magnetosomes of Biological Origin, By Magnetic Hyperthermia for the Treatment of Tumors

Author(s): Edouard Alphandéry

Pp: 218-248 (31)

DOI: 10.2174/9781681081496115060009

* (Excluding Mailing and Handling)

Abstract

This chapter describes a therapy for cancer using iron oxide nanoparticles, called magnetosomes, which are synthesized by magnetotactic bacteria. After intratumoral administration, magnetosomes extracted from magnetotactic bacteria are heated by applying an alternating magnetic field. The heat induces anti-tumor activity. This type of cancer therapy has essentially been developed using chemical nano-particles. Magnetosomes possess a series of advantages as compared with these chemical nanoparticles, such as a larger size and ferromagnetic behavior, which enable them to produce more heat and an arrangement in chains, which prevents aggregation. A preclinical proof of concept of the therapy, carried out on mice bearing MDA-MB231 breast tumors is presented and shows that it is possible to completely eradicate these tumors with the therapy. The latter French company called “Nanobacterie”, has been established in 2008 to develop the therapy.


Keywords: Alternating magnetic field, Cancer, Magnetotactic bacteria, Magnetosomes, Magnetic hyperthermia, Tumor.

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      • 11. app/Models/ContentAccess.php:647
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      • 11. app/Models/ContentAccess.php:647
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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 873352086 and j.to_ip >=873352086 )) and ((j.from_date <= 1740496353 and j.to_date >= 1740496353 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8226) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 873352086 and j.to_ip >=873352086 )) and ((j.from_date <= 1740496353 and j.to_date >= 1740496353 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8226) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 873352086 and j.to_ip >=873352086 )) and ((j.from_date <= 1740496353 and j.to_date >= 1740496353 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 8226)
      1.14msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1885 and `b`.`banner_from_date` <= 1740496353 and `b`.`banner_to_date` >= 1740496353 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.21msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1885
      • 3: 1740496353
      • 4: 1740496353
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='a889848aeff58c18e987e3c2c7c15774'
      270μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    6Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        DkusGno6YdwloE1UWyRBysAG460TR8pnm5o5OagU
        uc_cart_id
        a889848aeff58c18e987e3c2c7c15774
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/8226" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/8226
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImlwMWdhYUVXZElFUzFQRWJubERBMmc9PSIsInZhbHVlIjoicUZmWkFoZjFuSFNNZytVdE9rYnFSdDJzN3FsaDlaWnFIeTdwUGx6bU0rZz0iLCJtYWMiOiJhZTQwZTU1NzgyMWIxYWJjZDg3MjFhMGNhOGRhMDllN2FiMGFiNDM5YWVmNDUxMTVhMWY5NDgxODU5N2MzMjQ0IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImlwMWdhYUVXZElFUzFQRWJubERBMmc9PSIsInZhbHVlIjoicUZmWkFoZjFuSFNNZytVdE9rYnFSdDJzN3FsaDlaWnFIeTdwUGx6bU0rZz0iLCJtYWMiOiJhZTQwZTU1NzgyMWIx" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 15:12:33 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Im1KWERzVHVhSmJDYjVneHBvRER4ZGc9PSIsInZhbHVlIjoiSTZsRWNvRldyd21XMmM0VDZMV213T0l4eVJxYk9CUGNha1ZHb0ZKZWplRVN6djViQ0hJbEJvZHRPV1BUUGlsRS9ZUG5KVm04cWRCeVFiWU9BYy8zOHphS3AwYU5GZ1RIbnhsWVRIYmRqbk5vYTdGZGhCWC9CUW5ucCttK2Z2dkgiLCJtYWMiOiI5ZDMwNjJlMDBiMjAxYjY0MTJmMjMzMDlhZWQxMjYwNGYwYTFhNjkyNjViZGFhMGEwMWQyODU5MjI3ZmM5Y2YyIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 03:12:33 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Im1KWERzVHVhSmJDYjVneHBvRER4ZGc9PSIsInZhbHVlIjoiSTZsRWNvRldyd21XMmM0VDZMV213T0l4eVJxYk9CUGNha1ZHb0ZKZWplRVN6djViQ0hJbEJvZHRPV1BUUGlsRS9ZUG5KV" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ink0WFhHcjVNeXYvRk5lWXVRcThMZ0E9PSIsInZhbHVlIjoiYjE5QWR3dEF4R3JGdUt0emdzenNQeGpMNGdDUEpoazRWczhZZ1dvWWhkNG1lbEFxbmRZMlkrRXRYZU9NTGRsN3JyRS9uRm8vdWdoV2xjQzhMMDJlUVg0aCt5TnIyZWJrbkhzLzFlTVhSK2prYjd2L3FTUk9FajcrTHFmRWczRkQiLCJtYWMiOiJmMGIyOWNiMDhiNzJkNzEyMjViMTRjYzQ5MzI2ZDExMTE0Y2ZjNTliZDdmOGU3YjcyZjkxZWMxNjZjMDFhZTBjIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ink0WFhHcjVNeXYvRk5lWXVRcThMZ0E9PSIsInZhbHVlIjoiYjE5QWR3dEF4R3JGdUt0emdzenNQeGpMNGdDUEpoazRWczhZZ1dvWWhkNG1lbEFxbmRZMlkrRXR" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Im1KWERzVHVhSmJDYjVneHBvRER4ZGc9PSIsInZhbHVlIjoiSTZsRWNvRldyd21XMmM0VDZMV213T0l4eVJxYk9CUGNha1ZHb0ZKZWplRVN6djViQ0hJbEJvZHRPV1BUUGlsRS9ZUG5KVm04cWRCeVFiWU9BYy8zOHphS3AwYU5GZ1RIbnhsWVRIYmRqbk5vYTdGZGhCWC9CUW5ucCttK2Z2dkgiLCJtYWMiOiI5ZDMwNjJlMDBiMjAxYjY0MTJmMjMzMDlhZWQxMjYwNGYwYTFhNjkyNjViZGFhMGEwMWQyODU5MjI3ZmM5Y2YyIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 03:12:33 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Im1KWERzVHVhSmJDYjVneHBvRER4ZGc9PSIsInZhbHVlIjoiSTZsRWNvRldyd21XMmM0VDZMV213T0l4eVJxYk9CUGNha1ZHb0ZKZWplRVN6djViQ0hJbEJvZHRPV1BUUGlsRS9ZUG5KV" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ink0WFhHcjVNeXYvRk5lWXVRcThMZ0E9PSIsInZhbHVlIjoiYjE5QWR3dEF4R3JGdUt0emdzenNQeGpMNGdDUEpoazRWczhZZ1dvWWhkNG1lbEFxbmRZMlkrRXRYZU9NTGRsN3JyRS9uRm8vdWdoV2xjQzhMMDJlUVg0aCt5TnIyZWJrbkhzLzFlTVhSK2prYjd2L3FTUk9FajcrTHFmRWczRkQiLCJtYWMiOiJmMGIyOWNiMDhiNzJkNzEyMjViMTRjYzQ5MzI2ZDExMTE0Y2ZjNTliZDdmOGU3YjcyZjkxZWMxNjZjMDFhZTBjIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ink0WFhHcjVNeXYvRk5lWXVRcThMZ0E9PSIsInZhbHVlIjoiYjE5QWR3dEF4R3JGdUt0emdzenNQeGpMNGdDUEpoazRWczhZZ1dvWWhkNG1lbEFxbmRZMlkrRXR" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "DkusGno6YdwloE1UWyRBysAG460TR8pnm5o5OagU" "uc_cart_id" => "a889848aeff58c18e987e3c2c7c15774" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/8226" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 15:12:33GET/chapter/8226112198