Frontiers in Myocardia

Volume: 1

The Clinical Aspects of Septic Myocardiopathy

Author(s): Sabri Soussi and Matthieu Legrand

Pp: 132-139 (8)

DOI: 10.2174/9781681080604115010011

* (Excluding Mailing and Handling)

Abstract

Sepsis-induced myocardial dysfunction (SIMD) is a common and reversible complication in severe sepsis and septic shock patients. Its pathogenesis is complex and probably mediated by cytokines. Echocardiography is the gold standard to make the diagnosis of SIMD. Cardiac biomarkers have a high negative predictive value for SIMD. Norepinephrine is the first line vasopressor. Inotropic drugs should be used in the case of left ventricular systolic dysfunction associated with persisting tissular hypoperfusion.


Keywords: Diastolic dysfunction, Echocardiography, Heart failure, Hemodynamic, Monitoring, Mortality, Natriuretic peptides, Sepsis, Septic cardiomyopathy, Septic shock, Severe sepsis, Troponins.

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      • 17. app/Http/Controllers/ChapterController.php:1434
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      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      • 14. app/Models/Subject.php:238
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      390μsalphaeurekaselec_live_10_06_2022Subject.php#255
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      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
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      410μsalphaeurekaselec_live_10_06_2022Subject.php#255
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      • 15. app/Http/Controllers/ChapterController.php:1435
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      290μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
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      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      230μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
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      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740422799 and j.to_date >= 1740422799 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 7800) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740422799 and j.to_date >= 1740422799 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 7800) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740422799 and j.to_date >= 1740422799 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 7800)
      520μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1734 and `b`.`banner_from_date` <= 1740422799 and `b`.`banner_to_date` >= 1740422799 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.03msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1734
      • 3: 1740422799
      • 4: 1740422799
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='2d29cdb01c41d051faf5c5f1f56a8bf0'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    12Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        h5aBD8LyblWBwiui4newZnnOyVAqAKkuqDNr9LZP
        uc_cart_id
        2d29cdb01c41d051faf5c5f1f56a8bf0
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/7800" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/7800
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6InNtT0l5RnRONis5UktVWEhpd2pVL3c9PSIsInZhbHVlIjoicGtZQy9rL1h4N0NweFNHYmdTMUdML0ZmcjAvQlZZS29JUzZSU0dobk0zOD0iLCJtYWMiOiI5NWE4N2UzNDIyOWEyY2RhMjhiZmY5NTIwMjZiNGI0NmIwMzcwMzYzZmMyYzFiOWU4Yzg5MmNkYzdmYTY4NzdjIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6InNtT0l5RnRONis5UktVWEhpd2pVL3c9PSIsInZhbHVlIjoicGtZQy9rL1h4N0NweFNHYmdTMUdML0ZmcjAvQlZZS29JUzZSU0dobk0zOD0iLCJtYWMiOiI5NWE4N2UzNDIyOWEy" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 24 Feb 2025 18:46:39 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Im9jWkRaQUwxL2JrTzNpdFE4dHRlcGc9PSIsInZhbHVlIjoiQXQ3WVRhWHJ6WWVPUkswNFl2SFVnOC91YnZ4elhlemxSTEdTeGtRbUExazF3ZUVYV0VDaVc3WmhtdTA3NGltc0sxSW5QZkVOMm9SYnBjWUxrRUpNdUNmbDVxcGlVMmIzWUg2N3RvOVBqc05pdG9PZXhUWkN0akJKbDM4UG92eDQiLCJtYWMiOiI4NDM3MWM3NGZlMDEzMTVkZWRiZWI5NWJjNTJmNmZhODI4YTkxYTgwNWI1NTUyMGZjMjRmNWZlODNjYTliZjRjIiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 06:46:39 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Im9jWkRaQUwxL2JrTzNpdFE4dHRlcGc9PSIsInZhbHVlIjoiQXQ3WVRhWHJ6WWVPUkswNFl2SFVnOC91YnZ4elhlemxSTEdTeGtRbUExazF3ZUVYV0VDaVc3WmhtdTA3NGltc0sxSW5QZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImVpUjkwYXNHNVI4cUJ4dUV2SmxuU0E9PSIsInZhbHVlIjoidTNwNlgxdVNhRWwydmpGSVhCTURhdDFmSDFGRFNPTkZUMWVnVFV6MTdpMVdVSFBHc0N5QXk2WWxZaVVGSjN5U052WEFrVXNGajB4TDlqT3cvSUZnNVI1WGplQTU5dXIrN3J5V1lhQU83bWlPVFFTM0hYbW8vVkRmajRKd05sekQiLCJtYWMiOiJhNjgzMDJiNzAzZmI0NGY4NDkyZTdhZWU1MzU1NjE2YTc5ZTgyMjM2MjkwZDhmMTZjMWJjNmZjMjA4NGM3YzExIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6ImVpUjkwYXNHNVI4cUJ4dUV2SmxuU0E9PSIsInZhbHVlIjoidTNwNlgxdVNhRWwydmpGSVhCTURhdDFmSDFGRFNPTkZUMWVnVFV6MTdpMVdVSFBHc0N5QXk2WWx" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Im9jWkRaQUwxL2JrTzNpdFE4dHRlcGc9PSIsInZhbHVlIjoiQXQ3WVRhWHJ6WWVPUkswNFl2SFVnOC91YnZ4elhlemxSTEdTeGtRbUExazF3ZUVYV0VDaVc3WmhtdTA3NGltc0sxSW5QZkVOMm9SYnBjWUxrRUpNdUNmbDVxcGlVMmIzWUg2N3RvOVBqc05pdG9PZXhUWkN0akJKbDM4UG92eDQiLCJtYWMiOiI4NDM3MWM3NGZlMDEzMTVkZWRiZWI5NWJjNTJmNmZhODI4YTkxYTgwNWI1NTUyMGZjMjRmNWZlODNjYTliZjRjIiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 06:46:39 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Im9jWkRaQUwxL2JrTzNpdFE4dHRlcGc9PSIsInZhbHVlIjoiQXQ3WVRhWHJ6WWVPUkswNFl2SFVnOC91YnZ4elhlemxSTEdTeGtRbUExazF3ZUVYV0VDaVc3WmhtdTA3NGltc0sxSW5QZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImVpUjkwYXNHNVI4cUJ4dUV2SmxuU0E9PSIsInZhbHVlIjoidTNwNlgxdVNhRWwydmpGSVhCTURhdDFmSDFGRFNPTkZUMWVnVFV6MTdpMVdVSFBHc0N5QXk2WWxZaVVGSjN5U052WEFrVXNGajB4TDlqT3cvSUZnNVI1WGplQTU5dXIrN3J5V1lhQU83bWlPVFFTM0hYbW8vVkRmajRKd05sekQiLCJtYWMiOiJhNjgzMDJiNzAzZmI0NGY4NDkyZTdhZWU1MzU1NjE2YTc5ZTgyMjM2MjkwZDhmMTZjMWJjNmZjMjA4NGM3YzExIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6ImVpUjkwYXNHNVI4cUJ4dUV2SmxuU0E9PSIsInZhbHVlIjoidTNwNlgxdVNhRWwydmpGSVhCTURhdDFmSDFGRFNPTkZUMWVnVFV6MTdpMVdVSFBHc0N5QXk2WWx" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "h5aBD8LyblWBwiui4newZnnOyVAqAKkuqDNr9LZP" "uc_cart_id" => "2d29cdb01c41d051faf5c5f1f56a8bf0" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/7800" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-24 18:46:39GET/chapter/78001121914