Frontiers in Myocardia

Volume: 1

Septic Cariomyopathy: A Distinct Metabolic and Genetic Entity?

Author(s): Jochen Hinkelbein

Pp: 104-115 (12)

DOI: 10.2174/9781681080604115010009

* (Excluding Mailing and Handling)

Abstract

During the course of sepsis, myocardial dysfunction occurs in 20-30% of patients. Septic cardiomyopathy has a high mortality and the underlying molecular pathophysiology remains still largely unclear. Sepsis induced cardiac dysfunction (SICD) or septic cardiomyopathy (SC) gathered increasing denotation during the last years since mortality rates are high.

Septic shock is characterized by circulatory compromise, microcirculatory alterations and mitochondrial damage, which all reduce cellular energy production in the myocardium. As the specific underlying molecular causes of septic cardiomyopathy remain largely unclear, characteristic alterations in the organ proteome (“tissue proteomics”) and metabolome are of high interest to understand emerging dysfunction and to identify molecular details to establish new treatment approaches.

Thus, it is of outstanding importance to diagnose septic cardiomyopathy effectively being able to treat specifically this entity of a disease.


Keywords: Cardiac dysfunction, Heart, Protein alterations, Protein expression, Proteomics, Sepsis, Septic cardiomyopathy, Septic myocardial dysfunction.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59799503 and j.to_ip >=59799503 )) and ((j.from_date <= 1740421166 and j.to_date >= 1740421166 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 7798) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59799503 and j.to_ip >=59799503 )) and ((j.from_date <= 1740421166 and j.to_date >= 1740421166 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 7798) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59799503 and j.to_ip >=59799503 )) and ((j.from_date <= 1740421166 and j.to_date >= 1740421166 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 7798)
      570μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1734 and `b`.`banner_from_date` <= 1740421166 and `b`.`banner_to_date` >= 1740421166 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1734
      • 3: 1740421166
      • 4: 1740421166
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='6df1e3bd114f82ac26134b35ce67a06d'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    8Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        XCPgdGTdM1qyHC7bfSZNaCzeKAJEE3fxSRhpS037
        uc_cart_id
        6df1e3bd114f82ac26134b35ce67a06d
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/7798" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/7798
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IkFDYU5BZ3MxTjNmMWxCUFA0Q1kyYlE9PSIsInZhbHVlIjoiVC96UTl0eVVuRW9rRDhyMTk0cVVWRVNOTEpoQ29KOTM3TjlkbUlmSXZuST0iLCJtYWMiOiIyZjk0ZTFkODNhODY1ODkzMjNlMWM1ZjQ2MzFkMTJhNDczNmI5MWYyNjNiYjNlNjUzYjM2ZjBlOTFhNTAwNjUwIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IkFDYU5BZ3MxTjNmMWxCUFA0Q1kyYlE9PSIsInZhbHVlIjoiVC96UTl0eVVuRW9rRDhyMTk0cVVWRVNOTEpoQ29KOTM3TjlkbUlmSXZuST0iLCJtYWMiOiIyZjk0ZTFkODNhODY1" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 24 Feb 2025 18:19:26 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InE1cWtQS1lMelJJWkNtV2ZnK0cxR3c9PSIsInZhbHVlIjoiNEpZdUNHWW4rVVlSK3gwdzNNL2VQY3pQcXBUYXl6R1pXSWNBbXBxK3FUR3RXRDFOT1BWZklqdGMwZkNaUWlud3BuV2ZjOVpFY3RsUG1MK0lrSFdwQXIzc0hpMFhmK21ZSCtRTHV0VTdlZnA3eXNuZ2VuNUw0aldLazJmcUZMZHAiLCJtYWMiOiJjODkwMTcwNDdiOWZlMzZkNGEyNDZmZTBjNDE2OTEyNzNmZjZjYjcxYjIwMDBmMGE2NzkzZGQ4Yjk2NTNkNzAwIiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 06:19:26 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InE1cWtQS1lMelJJWkNtV2ZnK0cxR3c9PSIsInZhbHVlIjoiNEpZdUNHWW4rVVlSK3gwdzNNL2VQY3pQcXBUYXl6R1pXSWNBbXBxK3FUR3RXRDFOT1BWZklqdGMwZkNaUWlud3BuV2ZjO" 1 => "alphaeurekaselectnet_session=eyJpdiI6InFpTiswRjRtSEk5ZnZ6cElLaWNJK0E9PSIsInZhbHVlIjoiQ1ZvODQ2M3NEb2R2SmZKSkFnb1RYa0R1cGNOQXFaK1BWcGpmVjdLZnhUUE9YaHJqazNKYmZIY05MS3VXS3lQbXdNTy9LNzJRaWJMMElBTWxDQjYwckdPQkpSa0tqVzNucDdwblNoVUN4QmppVkRERzdjSlZndkxzZnVJZHRrWDgiLCJtYWMiOiJhMmRlYmQ1NzZjMTgyZDQ2N2IwMmM3NGQwYzhjNmU1ODM2NmYyZGNmOWJiNjg3M2RjOTg4N2RmYTQ3MGJkY2FjIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InFpTiswRjRtSEk5ZnZ6cElLaWNJK0E9PSIsInZhbHVlIjoiQ1ZvODQ2M3NEb2R2SmZKSkFnb1RYa0R1cGNOQXFaK1BWcGpmVjdLZnhUUE9YaHJqazNKYmZIY05" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InE1cWtQS1lMelJJWkNtV2ZnK0cxR3c9PSIsInZhbHVlIjoiNEpZdUNHWW4rVVlSK3gwdzNNL2VQY3pQcXBUYXl6R1pXSWNBbXBxK3FUR3RXRDFOT1BWZklqdGMwZkNaUWlud3BuV2ZjOVpFY3RsUG1MK0lrSFdwQXIzc0hpMFhmK21ZSCtRTHV0VTdlZnA3eXNuZ2VuNUw0aldLazJmcUZMZHAiLCJtYWMiOiJjODkwMTcwNDdiOWZlMzZkNGEyNDZmZTBjNDE2OTEyNzNmZjZjYjcxYjIwMDBmMGE2NzkzZGQ4Yjk2NTNkNzAwIiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 06:19:26 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InE1cWtQS1lMelJJWkNtV2ZnK0cxR3c9PSIsInZhbHVlIjoiNEpZdUNHWW4rVVlSK3gwdzNNL2VQY3pQcXBUYXl6R1pXSWNBbXBxK3FUR3RXRDFOT1BWZklqdGMwZkNaUWlud3BuV2ZjO" 1 => "alphaeurekaselectnet_session=eyJpdiI6InFpTiswRjRtSEk5ZnZ6cElLaWNJK0E9PSIsInZhbHVlIjoiQ1ZvODQ2M3NEb2R2SmZKSkFnb1RYa0R1cGNOQXFaK1BWcGpmVjdLZnhUUE9YaHJqazNKYmZIY05MS3VXS3lQbXdNTy9LNzJRaWJMMElBTWxDQjYwckdPQkpSa0tqVzNucDdwblNoVUN4QmppVkRERzdjSlZndkxzZnVJZHRrWDgiLCJtYWMiOiJhMmRlYmQ1NzZjMTgyZDQ2N2IwMmM3NGQwYzhjNmU1ODM2NmYyZGNmOWJiNjg3M2RjOTg4N2RmYTQ3MGJkY2FjIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InFpTiswRjRtSEk5ZnZ6cElLaWNJK0E9PSIsInZhbHVlIjoiQ1ZvODQ2M3NEb2R2SmZKSkFnb1RYa0R1cGNOQXFaK1BWcGpmVjdLZnhUUE9YaHJqazNKYmZIY05" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "XCPgdGTdM1qyHC7bfSZNaCzeKAJEE3fxSRhpS037" "uc_cart_id" => "6df1e3bd114f82ac26134b35ce67a06d" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/7798" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-24 18:19:26GET/chapter/77981121910