Frontiers in Anti-Cancer Drug Discovery

Volume: 3

Novel Strategies in the Drug Delivery Development of Anticancer Drugs: The Nanoparticulate Formulations

Author(s): Deepak Yadav, Mohammad F. Anwar, Suruchi Suri, Hemant Kardum, Manju Belwal, Sunanda Singh, Veena Garg and Mohd Asif

Pp: 233-261 (29)

DOI: 10.2174/9781608058846114030009

* (Excluding Mailing and Handling)

Abstract

Cytotoxic drugs are a diverse class of compounds that treat cancer primarily by killing cancerous cells that are rapidly growing and dividing along with cells that are meant for normal tissue function. A novel and suitable delivery system delivers the chemotherapeutic agents to cancerous tissues without harming healthy tissues and also retains these chemotherapeutic agents in the tumor area for a longer period of time that gives a boost to the therapy. Smaller size increases the surface area of the nanoparticles that enhances drug absorption or encapsulation and carries the drug into the blood in a shorter time period. In comparison with already existing delivery systems, nano sized delivery systems can penetrate much deeper into tumor tissue, generally taken up more efficiently by cells and reduce the toxicity of cancerous drug to healthy tissues. However, nanoparticulate systems are being researched throughout the world to increase the drug efficacy and to reduce toxicity. Thus, generally nanoparticulate systems work on passive targeting as well as on active targeting of the drug to the tumors. However, the research is still at a nascent stage and there is a need to understand the role of nano carriers in cancer treatment. This article summarizes various drug delivery technologies for chemotherapeutic agents, which are gaining more attention for better therapeutic response.


Keywords: Active targeting, dendrimers, micelles, nanoparticles, passive targeting, polymeric and solid lipid nanoparticles.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version168msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[20:31:17] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (93.24ms)time
  • Application (74.42ms)time
  • 1 x Booting (55.61%)
    93.24ms
    1 x Application (44.38%)
    74.42ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed20.3ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59620938','',1,1740515477,1740515477) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740515477
      1.07msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59620938','/chapter/6351',1,1740515477,1740515477)
      170μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59620938 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59620938) limit 1
      11.29msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59620938
      • 1: 59620938
      • 2: 59620938
      • 3: 59620938
      • 4: 59620938
      • 5: 59620938
      • 6: 59620938
      • 7: 59620938
      • 8: 59620938
      • 9: 59620938
      • 10: 59620938
      • 11: 59620938
      • 12: 59620938
      • 13: 59620938
      • 14: 59620938
      • 15: 59620938
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '6351' limit 1
      300μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 6351
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '6351' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.15msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 6351
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '6351'
      290μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 6351
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 132 limit 1
      210μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 132
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132) and se.ebook_id!=132 and v.ebook_status='1'
      820μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132) and se.ebook_id!=132 and v.ebook_status='1' limit 10 offset 0
      700μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132)
      370μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132) limit 10 offset 0
      390μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 1495 and `e`.`is_uploaded` = 1
      450μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 1495
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 132 and ebook_volume_id <> 1495 limit 1
      230μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 132
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '6351' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      270μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1495' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      240μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740515477 and j.to_date >= 1740515477 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1495) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740515477 and j.to_date >= 1740515477 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1495) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740515477 and j.to_date >= 1740515477 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1495)
      560μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740515477 and j.to_date >= 1740515477 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6351) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740515477 and j.to_date >= 1740515477 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6351) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740515477 and j.to_date >= 1740515477 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6351)
      520μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1495 and `b`.`banner_from_date` <= 1740515477 and `b`.`banner_to_date` >= 1740515477 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.07msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1495
      • 3: 1740515477
      • 4: 1740515477
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='7b4a12452601e235d55501b704ae1c3f'
      200μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    6Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        EeHZAiWfMXMoFBDxEGPf0Vso2DoPIJxqTXeoMao8
        uc_cart_id
        7b4a12452601e235d55501b704ae1c3f
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/6351" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/6351
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImwvYXJRL3dDNEVPSVp4UDlCT3lpNEE9PSIsInZhbHVlIjoiL0Fmcjh4WmI0Y3dGbDB3TUhRZE9CUTMxWWsrWTlHTkdQQkdObHNmWWdIMD0iLCJtYWMiOiJiNzI4N2FmZDY3Y2JlMWUwYjRiMzFhYTQ1OTk3NGI3YzNmOTg1MDJkZmQ0OTBlOWI0MDRmMDU2YmUxZDQyOTc0IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImwvYXJRL3dDNEVPSVp4UDlCT3lpNEE9PSIsInZhbHVlIjoiL0Fmcjh4WmI0Y3dGbDB3TUhRZE9CUTMxWWsrWTlHTkdQQkdObHNmWWdIMD0iLCJtYWMiOiJiNzI4N2FmZDY3Y2Jl" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 20:31:17 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImtpRlJqK1Z0elNPK3ZZYmdUTFdIdFE9PSIsInZhbHVlIjoiNUVOVVlKL2lnS3J3R3dadENIYWhzSjFZZ1V5bW1NZUdNZitFZTl6T3dTbU1jbjlOa0V1YklIckZOczRQNzRmZlY2T3ZVL2gyNjBTdG9IVS9qVkFsZTFJQnNSelFuU1dIMFpRV21RTHZ2M0paQnVFaVd4NEZUNENqLzl1RDdUR0siLCJtYWMiOiJkYzIyZWVmYjJhNDI2MTk4OGE2MDRhNmRmYzFlMjc0YWFjYjcwNDczOWY2YmUxM2U1NmI4NTkyODJhMDZlNTg0IiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 08:31:17 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImtpRlJqK1Z0elNPK3ZZYmdUTFdIdFE9PSIsInZhbHVlIjoiNUVOVVlKL2lnS3J3R3dadENIYWhzSjFZZ1V5bW1NZUdNZitFZTl6T3dTbU1jbjlOa0V1YklIckZOczRQNzRmZlY2T3ZVL" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkJtZGRvWC9qVXNScmcxOEtiV2lXQmc9PSIsInZhbHVlIjoiYldkVFBpa0xWOE9uV0NPQ1FCWXZWZkFoa2J3L3ZEakxiUFFTdzh5bUh1bHE0SGR1enIvY2xYbHhURjd6NTQxY0RHTEx0bk90L2QyS0wrcnNCejI2V2Y0VUU0TVUxdTVZM1JNM1c3VnZvNGxYelhYU2hWZEhZdEd1LzllVXV0Zm0iLCJtYWMiOiIyOTQ4NDcwZWVmYjY5NzQ4M2I1MjFiZDE2NDJmYTVlZjFjZTQ1ZjcyZTBlMGU1NjRmM2Q2OGRiNjNhN2NhODU1IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IkJtZGRvWC9qVXNScmcxOEtiV2lXQmc9PSIsInZhbHVlIjoiYldkVFBpa0xWOE9uV0NPQ1FCWXZWZkFoa2J3L3ZEakxiUFFTdzh5bUh1bHE0SGR1enIvY2xYbHh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImtpRlJqK1Z0elNPK3ZZYmdUTFdIdFE9PSIsInZhbHVlIjoiNUVOVVlKL2lnS3J3R3dadENIYWhzSjFZZ1V5bW1NZUdNZitFZTl6T3dTbU1jbjlOa0V1YklIckZOczRQNzRmZlY2T3ZVL2gyNjBTdG9IVS9qVkFsZTFJQnNSelFuU1dIMFpRV21RTHZ2M0paQnVFaVd4NEZUNENqLzl1RDdUR0siLCJtYWMiOiJkYzIyZWVmYjJhNDI2MTk4OGE2MDRhNmRmYzFlMjc0YWFjYjcwNDczOWY2YmUxM2U1NmI4NTkyODJhMDZlNTg0IiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 08:31:17 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImtpRlJqK1Z0elNPK3ZZYmdUTFdIdFE9PSIsInZhbHVlIjoiNUVOVVlKL2lnS3J3R3dadENIYWhzSjFZZ1V5bW1NZUdNZitFZTl6T3dTbU1jbjlOa0V1YklIckZOczRQNzRmZlY2T3ZVL" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkJtZGRvWC9qVXNScmcxOEtiV2lXQmc9PSIsInZhbHVlIjoiYldkVFBpa0xWOE9uV0NPQ1FCWXZWZkFoa2J3L3ZEakxiUFFTdzh5bUh1bHE0SGR1enIvY2xYbHhURjd6NTQxY0RHTEx0bk90L2QyS0wrcnNCejI2V2Y0VUU0TVUxdTVZM1JNM1c3VnZvNGxYelhYU2hWZEhZdEd1LzllVXV0Zm0iLCJtYWMiOiIyOTQ4NDcwZWVmYjY5NzQ4M2I1MjFiZDE2NDJmYTVlZjFjZTQ1ZjcyZTBlMGU1NjRmM2Q2OGRiNjNhN2NhODU1IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IkJtZGRvWC9qVXNScmcxOEtiV2lXQmc9PSIsInZhbHVlIjoiYldkVFBpa0xWOE9uV0NPQ1FCWXZWZkFoa2J3L3ZEakxiUFFTdzh5bUh1bHE0SGR1enIvY2xYbHh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "EeHZAiWfMXMoFBDxEGPf0Vso2DoPIJxqTXeoMao8" "uc_cart_id" => "7b4a12452601e235d55501b704ae1c3f" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/6351" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 20:31:17GET/chapter/6351112198