Abstract
The chemotherapy of solid tumors followed the path opened by breast cancer: the use of active single agents combined for greater effectiveness in advanced disease and for their potential role in combined modality regimens. By the end of the 1960s, over 20 chemotherapeutic drugs effective against various malignancies were available to investigate these approaches. The use of combination chemotherapy in epithelial ovarian cancer, small cell lung cancer and osteogenic sarcoma showed improved response rates and duration of remission compared to previously used single drugs. Postoperative combination chemotherapy improved the survival of patients with osteogenic sarcomas.
Keywords: Ovarian cancer, small cell lung cancer, osteogenic sarcoma.
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