Helicobacter Pylori: A Worldwide Perspective 2014

Development and Current State of Helicobacter pylori Research in Hungary

Author(s): György M. Buzás

Pp: 481-499 (19)

DOI: 10.2174/9781608057375114010023

* (Excluding Mailing and Handling)

Abstract

The discovery of H. pylori led to a paradigm shift in the Hungarian medical community about the pathogenesis and treatment of peptic ulcer disease. H. pylori is the most prevalent infection also in our country. Epidemiologic studies revealed an overall prevalence of 52-63% of the infection in healthy blood donors with an age-dependent increase and no geographic differences. Endoscopic studies found a 83-92% prevalence in duodenal and 63- 92% in gastric ulcer patients. All known diagnostic methods are available in Hungary: serology and endoscopic biopsy + histology are mainly used in practice, urea breath tests are reserved for eradication control. The test-and treat, search-and-treat and scope-and treat strategies are not, however, used systematically and their cost-benefit ratio has not been determined. Antimicrobial resistance testing encounters the same difficulties as in Western countries, while fluorescence in situ hybridisation and polymerase chain reaction-based methods are used in research centres. The first consensus meeting of the Helicobacter pylori Working Group of the Hungarian Society of Gastroentrerology was held in 2000 and the results updated in 2002, following the Maastricht I provisions. A meta-analysis of the Hungarian studies showed that between 1992-2002, the proton pump inhibitor- based triple therapies achieved an overall eradication rate of 82.9% (71.3-93.7%) on an intention-to-treat basis, and are the most extensively used regimens. The efficiency of second- and third-line therapies is, unfortunately, unacceptably low. Several groups of researchers participated in randomised controlled trials which were later incorporated in international guidelines. Resistance to chlarithromycin was low in the 1990’s, then increased to 18% between 2005- 2009 in Budapest, came it at 10% in towns around the country and remained low in rural areas. Basic research on H. pylori has been developed in university centres from Budapest, Pécs and Szeged and published in major journals of gastroenterology.


Keywords: Helicobacter pylori, epidemiology, eradication therapy, chlarithromycin resistance, extraintestinal manifestations.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version170msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[23:27:19] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (94.21ms)time
  • Application (76ms)time
  • 1 x Booting (55.35%)
    94.21ms
    1 x Application (44.65%)
    76.00ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed22.33ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316609994','',1,1739834839,1739834839) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739834839
      910μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316609994','/chapter/6148',1,1739834839,1739834839)
      140μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316609994 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316609994) limit 1
      12.6msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316609994
      • 1: 316609994
      • 2: 316609994
      • 3: 316609994
      • 4: 316609994
      • 5: 316609994
      • 6: 316609994
      • 7: 316609994
      • 8: 316609994
      • 9: 316609994
      • 10: 316609994
      • 11: 316609994
      • 12: 316609994
      • 13: 316609994
      • 14: 316609994
      • 15: 316609994
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '6148' limit 1
      260μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 6148
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '6148' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      550μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 6148
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '6148'
      210μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 6148
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 385 limit 1
      200μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 385
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=385) and se.ebook_id!=385 and v.ebook_status='1'
      2.44msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=385) and se.ebook_id!=385 and v.ebook_status='1' limit 10 offset 0
      710μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=385)
      380μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=385) limit 10 offset 0
      390μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 1478 and `e`.`is_uploaded` = 1
      430μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 1478
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 385 and ebook_volume_id <> 1478 limit 1
      220μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 385
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '6148' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      270μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1478' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      230μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316609994 and j.to_ip >=316609994 )) and ((j.from_date <= 1739834839 and j.to_date >= 1739834839 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1478) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316609994 and j.to_ip >=316609994 )) and ((j.from_date <= 1739834839 and j.to_date >= 1739834839 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1478) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316609994 and j.to_ip >=316609994 )) and ((j.from_date <= 1739834839 and j.to_date >= 1739834839 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1478)
      560μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316609994 and j.to_ip >=316609994 )) and ((j.from_date <= 1739834839 and j.to_date >= 1739834839 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6148) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316609994 and j.to_ip >=316609994 )) and ((j.from_date <= 1739834839 and j.to_date >= 1739834839 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6148) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316609994 and j.to_ip >=316609994 )) and ((j.from_date <= 1739834839 and j.to_date >= 1739834839 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6148)
      600μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1478 and `b`.`banner_from_date` <= 1739834839 and `b`.`banner_to_date` >= 1739834839 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1478
      • 3: 1739834839
      • 4: 1739834839
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='93431bc75c7c569477c67aa7e75278b9'
      190μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    5Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        uWGFRFbgdV26l7ODZv4WfA36ErQh6AIu94aVWJcJ
        uc_cart_id
        93431bc75c7c569477c67aa7e75278b9
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/6148" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/6148
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImZkL1BaTUpZQ0l5L01TSlVCcmxlY1E9PSIsInZhbHVlIjoiYkNUK2RheVdYbW53VkE0T1V0REZlcHpmRlUrOG0wbWR6TCtnZVZqMXoxRGMyZkQ5UzRXSEdQY09ZQ2hHYzIxVCIsIm1hYyI6ImQ3YTg3NGFmMGNhYjJkMmRjZTFhOTEyMmI4NzYwMTVmNzFjNWM0MzgyYTkzNWFmMjJmY2QxNThhZmE0MWY4MmEiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6InVoOUgzcmRVRlhLY0JKZ3UzN3d1d2c9PSIsInZhbHVlIjoiTVA5UlV6bUljUFRpNzBCWVpsUkc4dG16cWNFaTNHVC9OeUNrWGZHNGwxVm1BZEdaRlBTUDBmcE9tZmN1SkVuUHhXcWdNek50K09pZVJ4eThOd0RiVWI1R2QxMHdtaW5pMDk4MlNGa1VNekZMV1dCTWlram1VdzJpNFIxNkNEdDgiLCJtYWMiOiIzYjBmNzkzMDEyMjdlOGYyMmFjMmEyNjIwYWIyZWUwZDgxNTM1YmVhOTcxZThhM2RmM2M5NmEzNDA1YjI5MmNlIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6IjJGcE1HRHE4bjlmZ1kzSEFpUW9pS1E9PSIsInZhbHVlIjoiNzJjeVpVNEZFblZuUlNYS05YaTQ0Y3pLbktvbVBZbTZWY1VtMXdJbU5jcmpxdCs2T0tKVXY1Q0RYUFRCRis2OHVBanVZcFAxWm8xMk0xRUk0UzBNbVVic2RpdzMzYncwRzgwR1ZTMFhKOUlxTDh2S2NPZHR1WWhzZ2pkN2VZbVYiLCJtYWMiOiJjOGM5MzYyMDgzNTkyMWUyNjFhNzc1YWEzNzg4MTI4NjQ5YjU2ZjIwNWFlYjI3YjBmZGU4MmZiYjM1NGYwMjU1IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImZkL1BaTUpZQ0l5L01TSlVCcmxlY1E9PSIsInZhbHVlIjoiYkNUK2RheVdYbW53VkE0T1V0REZlcHpmRlUrOG0wbWR6TCtnZVZqMXoxRGMyZkQ5UzRXSEdQY09ZQ2hHYzIxVCIs" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:3 [ "wayfindertarget" => null "XSRF-TOKEN" => "uWGFRFbgdV26l7ODZv4WfA36ErQh6AIu94aVWJcJ" "alphaeurekaselectnet_session" => "F5nt6xlvcwBYcWvTejPA9W9n7A2sYASMh0AVFjmS" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:27:19 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik4zTzNhR00wbmVhY2NQZ25hdjZiWGc9PSIsInZhbHVlIjoiU21Ub01XZ0RHYnoxNVBRSHJWOFVTMm44QVVzSXpFZTB4Y0FCYUcvOGo3YkUrbDhvTFpSb1pVeXZ1SEp3WEdTR0tkbzRLMXBmU21UNlJHNE5RT2x2ay9NYmpSSTZlYk9kWDl4TExKUEpLVHVUS01HSHY2MUxrT3hIcjlvNlNxbUQiLCJtYWMiOiI2NjIzYzdlM2JmMjBjNDJkYmMxODhhNTg2ZjgxZGNjM2FlNDI4NzM0M2I4ZTE0NTEwOTI5OGNhODU4YTk0M2E0IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:27:19 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ik4zTzNhR00wbmVhY2NQZ25hdjZiWGc9PSIsInZhbHVlIjoiU21Ub01XZ0RHYnoxNVBRSHJWOFVTMm44QVVzSXpFZTB4Y0FCYUcvOGo3YkUrbDhvTFpSb1pVeXZ1SEp3WEdTR0tkbzRLM" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ii8ybC95a1VrT2xqSkNDVTNvRFhtZ1E9PSIsInZhbHVlIjoiVWdXVWpWaGs2NFMyMWQ5SUYrZ3hMclkvcU1YSjk3Y1VaU3Z3eUxYZUVBVHJETXVFVlVNY3JOaWtWMllPWG0vMnk0WVBPWEVNTnZPZVhINk9VTWYrNVVBc0ptM1ZSMlo3c25LUjFQaGpSTlJtZXc1dm93dGhrY203M0prV3Q4bU8iLCJtYWMiOiJiNTYwOTk2NGI0MThhOTMyYTExNTEzNzQ2ZjNmMjExYmFiZmUxZDFhZDY0NjdkN2E2NjI1MjAzODIxYzcwN2E0IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ii8ybC95a1VrT2xqSkNDVTNvRFhtZ1E9PSIsInZhbHVlIjoiVWdXVWpWaGs2NFMyMWQ5SUYrZ3hMclkvcU1YSjk3Y1VaU3Z3eUxYZUVBVHJETXVFVlVNY3JOaWt" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik4zTzNhR00wbmVhY2NQZ25hdjZiWGc9PSIsInZhbHVlIjoiU21Ub01XZ0RHYnoxNVBRSHJWOFVTMm44QVVzSXpFZTB4Y0FCYUcvOGo3YkUrbDhvTFpSb1pVeXZ1SEp3WEdTR0tkbzRLMXBmU21UNlJHNE5RT2x2ay9NYmpSSTZlYk9kWDl4TExKUEpLVHVUS01HSHY2MUxrT3hIcjlvNlNxbUQiLCJtYWMiOiI2NjIzYzdlM2JmMjBjNDJkYmMxODhhNTg2ZjgxZGNjM2FlNDI4NzM0M2I4ZTE0NTEwOTI5OGNhODU4YTk0M2E0IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:27:19 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ik4zTzNhR00wbmVhY2NQZ25hdjZiWGc9PSIsInZhbHVlIjoiU21Ub01XZ0RHYnoxNVBRSHJWOFVTMm44QVVzSXpFZTB4Y0FCYUcvOGo3YkUrbDhvTFpSb1pVeXZ1SEp3WEdTR0tkbzRLM" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ii8ybC95a1VrT2xqSkNDVTNvRFhtZ1E9PSIsInZhbHVlIjoiVWdXVWpWaGs2NFMyMWQ5SUYrZ3hMclkvcU1YSjk3Y1VaU3Z3eUxYZUVBVHJETXVFVlVNY3JOaWtWMllPWG0vMnk0WVBPWEVNTnZPZVhINk9VTWYrNVVBc0ptM1ZSMlo3c25LUjFQaGpSTlJtZXc1dm93dGhrY203M0prV3Q4bU8iLCJtYWMiOiJiNTYwOTk2NGI0MThhOTMyYTExNTEzNzQ2ZjNmMjExYmFiZmUxZDFhZDY0NjdkN2E2NjI1MjAzODIxYzcwN2E0IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ii8ybC95a1VrT2xqSkNDVTNvRFhtZ1E9PSIsInZhbHVlIjoiVWdXVWpWaGs2NFMyMWQ5SUYrZ3hMclkvcU1YSjk3Y1VaU3Z3eUxYZUVBVHJETXVFVlVNY3JOaWt" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "uWGFRFbgdV26l7ODZv4WfA36ErQh6AIu94aVWJcJ" "uc_cart_id" => "93431bc75c7c569477c67aa7e75278b9" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/6148" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:27:19GET/chapter/6148112197