Abstract
H. pylori antibiotic resistance is the main factor affecting the efficacy of the current H. pylori eradicating therapies. Epidemiological aspects and different resistance mechanisms (point mutations, redox intracellular potential, pump efflux systems, membrane permeability) to clarithromycin, metronidazole, quinolones, amoxicillin and tetracycline, are accurately detailed on the basis of the most recent data available from the literature. In addition, the impact of resistance toward each antibiotic on efficacy of current therapies is thoroughly described.
Keywords: Helicobacter pylori, epidemiology, therapy, eradication, antibiotic, resistance, clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, rifabutin, quinolones, point mutation, efflux pump.
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Cite this chapter as:
Vincenzo de Francesco ;Antibiotic Resistance of Helicobacter pylori: Worldwide Prevalence, Mechanisms and Impact on Therapy, Helicobacter Pylori: A Worldwide Perspective 2014 (2014) 1: 411. https://doi.org/10.2174/9781608057375114010021
DOI https://doi.org/10.2174/9781608057375114010021 |
Publisher Name Bentham Science Publisher |