Helicobacter Pylori: A Worldwide Perspective 2014

Helicobacter pylori in Israel: Epidemiology, Pathophysiology, Diagnosis, Management and Resistance to Therapy

Author(s): Haim Shmuely and Yaron Niv

Pp: 169-182 (14)

DOI: 10.2174/9781608057375114010010

* (Excluding Mailing and Handling)

Abstract

In Israel, there is a 60% prevalence of H. pylori infection in the adult population. The annual incidence of gastric cancer is approximately 15 per 100,000 population. The male/female ratio for a positive 13C urea breath test (UBT) in diagnosing H. pylori infection is 1:1.77. Women have significantly higher UBT results than men. H. pylori infection is associated with a more severe inflammatory reaction, decreased gastric acid secretion and increased mucin secretion in relatives of patients with gastric cancer. Primary resistance to clarithromycin and metronidazole has been reported as 8.2% and 38.2%, respectively. Secondary resistance of clinical isolates from previously treated adults to clarithromycin, metronidazole, and levofloxacin is 65.7%, 57.1%, and 18.6%, respectively. Resistance to both clarithromycin and metronidazole is 32.8%, and to clarithromycin, metronidazole, and levofloxacin, 12.8%. All isolates are sensitive both to amoxicillin and tetracycline. In untreated children, the rate of resistance to metronidazole is 19%, and to clarithromycin, 25%. Corresponding rates among the isolates from children previously treated for H. pylori are 52% and 42%. No resistance is found to amoxicillin, tetracycline or levofloxacin in either group. Sequential regimen, used as primary therapy, attained significantly higher eradication rates than the standard triple therapy. The addition of cranberry to triple therapy improves the rate of H. pylori eradication in females. Susceptibility-guided retreatment is associated with better eradication rates than empiric treatment. The annual recurrence rate of H. pylori after successful eradication in Israel is 0.37% to 0.55%.


Keywords: Helicobacter, Israel, recurrence, recrudescence, reinfection, developed countries, developing countries, clarithromycin, metronidazole, amoxicillin, tetracycline, sequential therapy, concomitant therapy, urea breath test, rapid urease test, stool antigen test, gastroscopy, gastric cancer, peptic ulcer, maltoma.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1739835022 and j.to_date >= 1739835022 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6135) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1739835022 and j.to_date >= 1739835022 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6135) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1739835022 and j.to_date >= 1739835022 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 6135)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1478 and `b`.`banner_from_date` <= 1739835022 and `b`.`banner_to_date` >= 1739835022 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.07msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1478
      • 3: 1739835022
      • 4: 1739835022
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='f25c5ce1657291093f0fd2045ebdb515'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    20Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        Sv232siUhwAomPcJULemFdg1xcNqnXtWiqTf32rh
        uc_cart_id
        f25c5ce1657291093f0fd2045ebdb515
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/6135" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/6135
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
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        response_headers
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:30:22GET/chapter/61351121922