Frontiers in Anti-Cancer Drug Discovery

Volume: 2

Strategies for Improving the Systemic Delivery of Oncolytic Adenoviruses and Plasmids: Potential Application of Non-Viral Carriers

Author(s): Mireia Agirre, Jon Zarate, Gustavo Puras, Luis A. Rojas, Ramon Alemany and José L. Pedraz

Pp: 190-225 (36)

DOI: 10.2174/9781608058082113020008

* (Excluding Mailing and Handling)

Abstract

Virotherapy is the use of oncolytic or tumor-selective viruses to treat cancer. The replication of the virus inside a tumor can debulk the tumor mass and simultaneously, revert the immune suppressor environment that causes the immune escape of tumor cells. This therapeutic approach was discovered ten years ago but it has been renewed in the last decade with designed viruses. Adenovirus (Ad) is a nonenveloped DNA virus that infects broadly tumor cells and it has been frequently used in cancer gene therapy and virotherapy. A very high level of tumor-specific replication has been obtained with adenoviruses by replacing early viral gene promoters with tumorselective promoters. However, the complex Ad capsid interactions with blood proteins and cells and, also with liver and spleen macrophages result in rapid blood clearance and the prevention of systemic tumor targeting. To settle these problems, a new field is emerging where an oncolytic Ad genome is complexed to non-viral vectors to target tumors.


Keywords: Oncolytic viruses, non-viral vectors, oncolytic adenoviral genome, modified adenoviruses, tumor targeting.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version206msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[23:23:31] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (108ms)time
  • Application (97.84ms)time
  • 1 x Booting (52.39%)
    108ms
    1 x Application (47.61%)
    97.84ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed29.2ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51399716','',1,1739834611,1739834611) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739834611
      1.84msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51399716','/chapter/5911',1,1739834611,1739834611)
      210μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) limit 1
      17.74msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51399716
      • 1: 51399716
      • 2: 51399716
      • 3: 51399716
      • 4: 51399716
      • 5: 51399716
      • 6: 51399716
      • 7: 51399716
      • 8: 51399716
      • 9: 51399716
      • 10: 51399716
      • 11: 51399716
      • 12: 51399716
      • 13: 51399716
      • 14: 51399716
      • 15: 51399716
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '5911' limit 1
      280μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 5911
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '5911' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      960μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 5911
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '5911'
      680μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 5911
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 132 limit 1
      210μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 132
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132) and se.ebook_id!=132 and v.ebook_status='1'
      860μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132) and se.ebook_id!=132 and v.ebook_status='1' limit 10 offset 0
      710μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132)
      390μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=132) limit 10 offset 0
      410μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 1345 and `e`.`is_uploaded` = 1
      940μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 1345
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 132 and ebook_volume_id <> 1345 limit 1
      260μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 132
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '5911' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1345' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      320μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834611 and j.to_date >= 1739834611 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1345) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834611 and j.to_date >= 1739834611 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1345) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834611 and j.to_date >= 1739834611 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1345)
      750μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834611 and j.to_date >= 1739834611 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 5911) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834611 and j.to_date >= 1739834611 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 5911) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834611 and j.to_date >= 1739834611 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 5911)
      710μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1345 and `b`.`banner_from_date` <= 1739834611 and `b`.`banner_to_date` >= 1739834611 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.35msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1345
      • 3: 1739834611
      • 4: 1739834611
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='cd40582b2150d48a8a658460c1d80c2a'
      240μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    5Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        zsArVsQ96x6peanjLpSpbWfXRbeEg3z1jNafbREp
        uc_cart_id
        cd40582b2150d48a8a658460c1d80c2a
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/5911" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/5911
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "_ga_9F3B5VV3T3=GS1.1.1739834602.1.0.1739834602.60.0.0; _ga=GA1.1.1712530691.1739834603; fpestid=1SSSMo156X3KKk1B0lqk1TVI2x5x9IGIZ5eP2fsRZBTRnVFcDf5p3QtHA60gnYdNEtcWhQ; wayfindertarget=eyJpdiI6IkdyZWcrSTRnUk14cExKQXd1c1dQdUE9PSIsInZhbHVlIjoid2ZmRjl4MGJlaGNJV2lJZEkxV3Y4cjNyd1B1eEUwYVVrd2ZwNGYxcWNXOD0iLCJtYWMiOiJlMDA2ZmZiZmZhNWRkYjg2ZmY2NzdjNTM0ZmE5YzdiYmFmMjQxNzM2ZGM2NDcyMWY1ZWRkNTZhYjk2YjZkODE4IiwidGFnIjoiIn0%3D; XSRF-TOKEN=eyJpdiI6IlhSY0greXMrSFUxY3VjNG1sdDc3bHc9PSIsInZhbHVlIjoiTUl5V2Q0LzlLbFJOampHelN6UlZmbFJwTS9HdmtPNXFkYUdmQ0E4aS91UFRtQXc5aUNpZjU0MGZwM25lcXBrekRWSkJ5cEE3ZXRJTGpFR3d1UHh5ZFBYelIvbFJnV0xxSFZ1RkJJRjhsYmpKZDVUNWJKL2FsM2IzR241U2xjRkMiLCJtYWMiOiJmMzRmZTkyM2U0MjY0ZjM0ODAwNGZjODhkNjRlMjRiNjkzNTcxZDM4NDMxMmNlZWUxMGI4YzQwMTRiZDcwYzczIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6Ik4xTGxnT1BwZWpPR2N2K1JlanZSU1E9PSIsInZhbHVlIjoiU0duN0ZoL2o2V0c2K1NlazJiZ3IxUWN3RlJ0ZTU5bDZteGJIYTUrNXZ6L0xsYktVd0RzdkgyR0lPbHdDeWZIaWxzaHN6UmowSnIrb0ZWNmdNVkZBUWdRUFkrdDR0SWtuSGt4K3ZOekpSTGY3SFViQ2tHSkpLWjh1QWpHOU04eksiLCJtYWMiOiI4MGQ3YWI5MWIzZjg4Nzc5ZGE2YTg5NjBiMTQ2MjdkN2ZkYmJkZTIzZTA1YTA4ZjJiNGYwN2Y3ZDg2YzVlMWI3IiwidGFnIjoiIn0%3D_ga_9F3B5VV3T3=GS1.1.1739834602.1.0.1739834602.60.0.0; _ga=GA1.1.1712530691.1739834603; fpestid=1SSSMo156X3KKk1B0lqk1TVI2x5x9IGIZ5eP2fsRZBTRnVFcDf5p3QtHA60gnYdN" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:6 [ "_ga_9F3B5VV3T3" => null "_ga" => null "fpestid" => null "wayfindertarget" => null "XSRF-TOKEN" => "zsArVsQ96x6peanjLpSpbWfXRbeEg3z1jNafbREp" "alphaeurekaselectnet_session" => "SMLtnIhfNMB14Qa71GIibu70kssGFeNj0dxKhxny" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:23:31 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjY5ZTNuR3IxaUs1eWdOU1Vqcm1kcUE9PSIsInZhbHVlIjoiSWY5c2x6c1JJZGpWOFRXTm1vallGLzJNb29DS2oycTgxb1IvVENyRDV3TmNoT290RG9sMDIydkM5NnhENTQ2RUpBLzAyVjZ0OUt4V3dlZkVLZmZyUHJURE5ZRzJDU1A2ckNHbzRZM3NvL2tERFpZc2t0bHA5MDgwN2hOV3IzalEiLCJtYWMiOiJmZWYzMWZkYTUwYTUzYzYyNGYzN2U5OTBlMmNjOWIwZjE2MTJkOTIzODBjNTc5YTYyODkzODdhNzExN2ViYmM5IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:23:31 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjY5ZTNuR3IxaUs1eWdOU1Vqcm1kcUE9PSIsInZhbHVlIjoiSWY5c2x6c1JJZGpWOFRXTm1vallGLzJNb29DS2oycTgxb1IvVENyRDV3TmNoT290RG9sMDIydkM5NnhENTQ2RUpBLzAyV" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImtnbWd2a1BpOTRWSDYvbVhtSVpKTVE9PSIsInZhbHVlIjoieGdhazV4UmZPaEpBSlY1WWVCT1d4MENiRTNPOGtoYzFIVWc0MUlqOHJpL0FicFphUnZlbEozQVhnL2ZpeXkwcXlTcHRoUEtyL2pBelJTRXVITnVScCtIMDlhN1V2VFVQaU1BM09HMFJ2eXRCdFBYNmdUUWRuRW1ZeStTd2lYTEciLCJtYWMiOiI1ZjI3YzQzMWMzMDc5MzI5OTdlMDMzMTI5MDdmZmQ5Nzc0MTk1N2NmMGQ4MjRiY2NlMDQyMzczZGFjZTg0MWRiIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6ImtnbWd2a1BpOTRWSDYvbVhtSVpKTVE9PSIsInZhbHVlIjoieGdhazV4UmZPaEpBSlY1WWVCT1d4MENiRTNPOGtoYzFIVWc0MUlqOHJpL0FicFphUnZlbEozQVh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjY5ZTNuR3IxaUs1eWdOU1Vqcm1kcUE9PSIsInZhbHVlIjoiSWY5c2x6c1JJZGpWOFRXTm1vallGLzJNb29DS2oycTgxb1IvVENyRDV3TmNoT290RG9sMDIydkM5NnhENTQ2RUpBLzAyVjZ0OUt4V3dlZkVLZmZyUHJURE5ZRzJDU1A2ckNHbzRZM3NvL2tERFpZc2t0bHA5MDgwN2hOV3IzalEiLCJtYWMiOiJmZWYzMWZkYTUwYTUzYzYyNGYzN2U5OTBlMmNjOWIwZjE2MTJkOTIzODBjNTc5YTYyODkzODdhNzExN2ViYmM5IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:23:31 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjY5ZTNuR3IxaUs1eWdOU1Vqcm1kcUE9PSIsInZhbHVlIjoiSWY5c2x6c1JJZGpWOFRXTm1vallGLzJNb29DS2oycTgxb1IvVENyRDV3TmNoT290RG9sMDIydkM5NnhENTQ2RUpBLzAyV" 1 => "alphaeurekaselectnet_session=eyJpdiI6ImtnbWd2a1BpOTRWSDYvbVhtSVpKTVE9PSIsInZhbHVlIjoieGdhazV4UmZPaEpBSlY1WWVCT1d4MENiRTNPOGtoYzFIVWc0MUlqOHJpL0FicFphUnZlbEozQVhnL2ZpeXkwcXlTcHRoUEtyL2pBelJTRXVITnVScCtIMDlhN1V2VFVQaU1BM09HMFJ2eXRCdFBYNmdUUWRuRW1ZeStTd2lYTEciLCJtYWMiOiI1ZjI3YzQzMWMzMDc5MzI5OTdlMDMzMTI5MDdmZmQ5Nzc0MTk1N2NmMGQ4MjRiY2NlMDQyMzczZGFjZTg0MWRiIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6ImtnbWd2a1BpOTRWSDYvbVhtSVpKTVE9PSIsInZhbHVlIjoieGdhazV4UmZPaEpBSlY1WWVCT1d4MENiRTNPOGtoYzFIVWc0MUlqOHJpL0FicFphUnZlbEozQVh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "zsArVsQ96x6peanjLpSpbWfXRbeEg3z1jNafbREp" "uc_cart_id" => "cd40582b2150d48a8a658460c1d80c2a" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/5911" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:23:31GET/chapter/5911112197