Abstract
Familial amyloidosis ATTR V30M is an hereditary disorder, the most frequent type of transthyretin related amyloidosis. The main manifestation of the disease is a sensory-motor and autonomic polyneuropathy. Other manifestations occur such as cardiovascular, gastrointestinal, ocular, renal and hematological disorders. Anemia is a common feature, and occurs late in the disease course. It is associated with low erythropoietin production. Decreased production can start early in the course of the disease and precede clinical symptoms. The possible underlying pathogenic mechanisms are discussed.
Keywords: Familial amyloidosis ATTR V30M, transthyretin, anemia, EPO, neuropathy, kidney, glaucoma, neuroprotection.
Related Journals
Current Drug Delivery
Applied Drug Research, Clinical Trials and Regulatory Affairs
Drug Metabolism and Bioanalysis Letters
Current Bioactive Compounds
Current Drug Safety
Drug Delivery Letters
Recent Advances in Anti-Infective Drug Discovery
Recent Advances in Drug Delivery and Formulation
Reviews on Recent Clinical Trials
Current Drug Metabolism
Related Books
A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems
Angiogenesis & Therapeutic Targets In Cancer
Anti-Angiogenesis Drug Discovery and Development
Anti-Angiogenesis Drug Discovery and Development
Anti-Angiogenesis Drug Discovery and Development
Anti-Angiogenesis Drug Discovery and Development
Anti-Angiogenesis Drug Discovery and Development
Biopolymers In Drug Delivery: Recent Advances and Challenges
Chemoinformatics: Directions Toward Combating Neglected Diseases
Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms