Abstract
Ocular pharmacokinetics is a core component in the development of therapeutics for eye diseases. In this chapter, we provide a description of the following concepts and strategies that undergird when and where microdialysis may be a significant advance in the armamentarium of approaches for establishing PK/PD relationships in ophthalmology. We cover the following topics:
• Understanding the current limitations in PK/PD with conventional sampling approaches
• Progress report on advances in the use of microdialysis in ophthalmology
• Preclinical vs. clinical ocular PK cases studies
• Roadblocks to microdialysis in ophthalmology
o Probe design and probe recovery
o Bioanalytical limitations
o Invasiveness of probe implantation
o Analyte properties and perfusion flow rate
• Strategies for design of an ideal microdialysis experiment
• Next advances in microdialysis
Keywords: Microdialysis, eye, pharmacokinetics, drug delivery, posterior segment, anterior segment, microdialysis probes.
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