Abstract
α-Unsubstituted β-hydroxy acids (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids.
Keywords: 3-hydroxycarboxylic acids, asymmetric aldol reactions, acetate aldol reactions, Reformatsky reaction, asymmetric reduction, Arndt-Eistert homologation, Wolff-rearrangement, beta-lactones, cyclic sulfites, reductive cleavage, green plastics, statines, 3-hydroxytetradecanoic acid, Mukaiyama aldol reaction, chiral auxiliaries, chiral catalysts, 3-oxo-carboxylic acids, BINAP, asymmetric conjugate radical addition, catalytic desymmetrization.
Related Journals
Current Chinese Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Anti-Cancer Agents in Medicinal Chemistry
Current Chinese Science
Mini-Reviews in Organic Chemistry
Current Organic Chemistry
Current Organic Synthesis
Letters in Organic Chemistry
The Natural Products Journal
Current Microwave Chemistry
Related Books
A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth
Advances in Anticancer Agents in Medicinal Chemistry
Advances in Anticancer Agents in Medicinal Chemistry
Advances in Combinatorial Chemistry & High Throughput Screening
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)
Advances in Protein and Peptide Sciences
An Account of Thermodynamic Entropy
Applications of Modern Mass Spectrometry