Epigenetics of Lifestyle

Epigenetics of Stress

Author(s): Andrew Collins, María Gutièrrez-Mecinas, Alexandra F. Trollope and Johannes M.H.M. Reul

Pp: 70-89 (20)

DOI: 10.2174/978160805299811201010070

* (Excluding Mailing and Handling)

Abstract

Poor stress-coping is associated with a greater chance of developing a psychiatric illness such as post-traumatic stress disorder (PTSD) or depression. Lifestyle interventions which facilitate more appropriate responses to stress are much sought after. Exercise is one such intervention and is now commonly being prescribed as a cotreatment along with drugs for treating depression. Exercised rodents display reduced anxiety and impulsivity in a variety of behavioral paradigms. Rats exposed to psychological stress show differential epigenetic and gene expression mechanisms at the dentate gyrus (DG) after long-term voluntary exercise. Alterations within ERK MAPK signalling to chromatin seem to modulate the number of epigenetically marked neurons in the DG, improving cognitive responses to a stress-related event. Other lifestyle interventions such as nutrition or better maternal care in early life have been shown to induce changes at the epigenome which impact positively on mental health.


Keywords: Stress, brain, hippocampus, learning, memory, chromatin, histone, exercise, glucocorticoid hormone, HPA axis, dentate gyrus, ERK MAPK, MSK1, immediate early gene, PTSD, anxiety, depression, cognition, adaptation, early life experience, DNA methylation, c-Fos, Egr-1, social defeat, CREB.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988715 and j.to_date >= 1739988715 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 4354) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988715 and j.to_date >= 1739988715 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 4354) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59699349 and j.to_ip >=59699349 )) and ((j.from_date <= 1739988715 and j.to_date >= 1739988715 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 4354)
      640μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1105 and `b`.`banner_from_date` <= 1739988715 and `b`.`banner_to_date` >= 1739988715 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.01msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1105
      • 3: 1739988715
      • 4: 1739988715
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4d5a63ff5d5f608240b1ec6974f45476'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    25Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        6Iegd3bbNFt6XtrChCqBDApxfv6PXD5bFjWsPKmA
        uc_cart_id
        4d5a63ff5d5f608240b1ec6974f45476
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/4354" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/4354
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6InJGeXVuN21mNW5Hbkd1eVRJSUYrZGc9PSIsInZhbHVlIjoidFd2L001K3VSVUhucnl4MGk0Mko5Y1JkYmlLc2pjeGlGbExsWjdnUmU1cz0iLCJtYWMiOiJiYTUzM2EzMDRkZTE2ZmMxZmY2NDJmZmY5YmNkM2Q4MjlkMDM3Nzc4OTAzOGExZWQ4NWE3YjlkNzkwNmEyODU1IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6InJGeXVuN21mNW5Hbkd1eVRJSUYrZGc9PSIsInZhbHVlIjoidFd2L001K3VSVUhucnl4MGk0Mko5Y1JkYmlLc2pjeGlGbExsWjdnUmU1cz0iLCJtYWMiOiJiYTUzM2EzMDRkZTE2" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:11:55 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InRVWEt0dmJUbTBsTkF4aWRzOTAwcGc9PSIsInZhbHVlIjoiS3AxU3paUUVTQUI4NnMwOW5rQng1K3hDcTExYjVKcE9Jd2ZMRmxvc3lGcEszanluc3poMkphOGFoZ2MvMW5xV3VCRkxBZy9reUlXVGlNeG1EREt5ZG52ZW1oYlNVT0tDbFpXRm5YOGZ2QklLeUJyeUd4T2lwM2Yxa1k1ZmkydEQiLCJtYWMiOiJhMzE0MTM1NWNjYzNjY2NhMWIyOTEwZDQ1YWU1YTAzMjMxMDhlMmYzY2JjOWVmZTY5NWIzMzdhZGQxMTM0OTFkIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:11:55 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InRVWEt0dmJUbTBsTkF4aWRzOTAwcGc9PSIsInZhbHVlIjoiS3AxU3paUUVTQUI4NnMwOW5rQng1K3hDcTExYjVKcE9Jd2ZMRmxvc3lGcEszanluc3poMkphOGFoZ2MvMW5xV3VCRkxBZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlBoK2dQdmpNdlNCSnVwQXAvTnV0S3c9PSIsInZhbHVlIjoiTk93TS9tRGxxdjZyaUdPNG9rOXJFakEybXZqZlJiYnhsZEpjbm1TRGlzN1JmcGlBQ1VZelNxVEhBUVgzc3R2ME9nNkxpeXBlcG1mUmllcTFSalZSVzRnV3RTYlM1WFdNUHFhUk5JTXR5L3NGa0p1UFUvOTFobDRhZlhjQTZ3SjAiLCJtYWMiOiIzMTUzZDg1NWE2ZmEwM2EzNWNlM2FhNDdlNjc0OGQ2MmMyZWZlMWQxYzFiNWRkZjQ4NzBkN2VhMDI5ZDAzNTRhIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IlBoK2dQdmpNdlNCSnVwQXAvTnV0S3c9PSIsInZhbHVlIjoiTk93TS9tRGxxdjZyaUdPNG9rOXJFakEybXZqZlJiYnhsZEpjbm1TRGlzN1JmcGlBQ1VZelNxVEh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InRVWEt0dmJUbTBsTkF4aWRzOTAwcGc9PSIsInZhbHVlIjoiS3AxU3paUUVTQUI4NnMwOW5rQng1K3hDcTExYjVKcE9Jd2ZMRmxvc3lGcEszanluc3poMkphOGFoZ2MvMW5xV3VCRkxBZy9reUlXVGlNeG1EREt5ZG52ZW1oYlNVT0tDbFpXRm5YOGZ2QklLeUJyeUd4T2lwM2Yxa1k1ZmkydEQiLCJtYWMiOiJhMzE0MTM1NWNjYzNjY2NhMWIyOTEwZDQ1YWU1YTAzMjMxMDhlMmYzY2JjOWVmZTY5NWIzMzdhZGQxMTM0OTFkIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:11:55 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InRVWEt0dmJUbTBsTkF4aWRzOTAwcGc9PSIsInZhbHVlIjoiS3AxU3paUUVTQUI4NnMwOW5rQng1K3hDcTExYjVKcE9Jd2ZMRmxvc3lGcEszanluc3poMkphOGFoZ2MvMW5xV3VCRkxBZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlBoK2dQdmpNdlNCSnVwQXAvTnV0S3c9PSIsInZhbHVlIjoiTk93TS9tRGxxdjZyaUdPNG9rOXJFakEybXZqZlJiYnhsZEpjbm1TRGlzN1JmcGlBQ1VZelNxVEhBUVgzc3R2ME9nNkxpeXBlcG1mUmllcTFSalZSVzRnV3RTYlM1WFdNUHFhUk5JTXR5L3NGa0p1UFUvOTFobDRhZlhjQTZ3SjAiLCJtYWMiOiIzMTUzZDg1NWE2ZmEwM2EzNWNlM2FhNDdlNjc0OGQ2MmMyZWZlMWQxYzFiNWRkZjQ4NzBkN2VhMDI5ZDAzNTRhIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IlBoK2dQdmpNdlNCSnVwQXAvTnV0S3c9PSIsInZhbHVlIjoiTk93TS9tRGxxdjZyaUdPNG9rOXJFakEybXZqZlJiYnhsZEpjbm1TRGlzN1JmcGlBQ1VZelNxVEh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "6Iegd3bbNFt6XtrChCqBDApxfv6PXD5bFjWsPKmA" "uc_cart_id" => "4d5a63ff5d5f608240b1ec6974f45476" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/4354" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:11:55GET/chapter/43541121927