MicroRNAs and Cardiovascular Disease

miRNAs in Cardiac Metabolism

Author(s): Zhiguo Wang

Pp: 117-120 (4)

DOI: 10.2174/978160805184711001010117

* (Excluding Mailing and Handling)

Abstract

This chapter aims to provide an implicit introduction to the role of miRNAs in regulating cardiac metabolism. The homeostasis of glucose, lipid, protein, and energy, which is critical for normal cardiovascular function, is maintained by cellular metabolism. Metabolic perturbation occurs in various types of cardiac disease, including myocardial ischemia, cardiac hypertrophy, heart failure, diabetic cardiomyopathy, atherosclerosis, etc. The depletion of high-energy-phosphate metabolites may contribute to heart failure, and a decreased PCr/ATP ratio has been found in cardiac muscle of heart failure patients and animal models of heart failure. A major determinant of glycolytic flux is glucose transport; glucose enters cardiac cells via the facilitative glucose transporters GLUT1 and GLUT4. Several miRNAs have been demonstrated to produce regulatory effects on GLUT4, cellular ATP level, and the pleiotropic factor IGF-1. A succinct summary on these studies is given in this chapter.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version181msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[21:45:52] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (93.35ms)time
  • Application (87.73ms)time
  • 1 x Booting (51.55%)
    93.35ms
    1 x Application (48.45%)
    87.73ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed31.18ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316145883','',1,1740347152,1740347152) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740347152
      1.07msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316145883','/chapter/3237',1,1740347152,1740347152)
      210μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316145883 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316145883) limit 1
      17.46msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316145883
      • 1: 316145883
      • 2: 316145883
      • 3: 316145883
      • 4: 316145883
      • 5: 316145883
      • 6: 316145883
      • 7: 316145883
      • 8: 316145883
      • 9: 316145883
      • 10: 316145883
      • 11: 316145883
      • 12: 316145883
      • 13: 316145883
      • 14: 316145883
      • 15: 316145883
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '3237' limit 1
      300μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 3237
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '3237' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      740μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 3237
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '3237'
      260μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 3237
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 209 limit 1
      280μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 209
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=209) and se.ebook_id!=209 and v.ebook_status='1'
      3.46msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=209) and se.ebook_id!=209 and v.ebook_status='1' limit 10 offset 0
      1.01msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=209)
      530μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=209) limit 10 offset 0
      570μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 1014 and `e`.`is_uploaded` = 1
      670μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 1014
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 209 and ebook_volume_id <> 1014 limit 1
      310μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 209
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '3237' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      410μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1014' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      380μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316145883 and j.to_ip >=316145883 )) and ((j.from_date <= 1740347152 and j.to_date >= 1740347152 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1014) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316145883 and j.to_ip >=316145883 )) and ((j.from_date <= 1740347152 and j.to_date >= 1740347152 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1014) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316145883 and j.to_ip >=316145883 )) and ((j.from_date <= 1740347152 and j.to_date >= 1740347152 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1014)
      860μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316145883 and j.to_ip >=316145883 )) and ((j.from_date <= 1740347152 and j.to_date >= 1740347152 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 3237) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316145883 and j.to_ip >=316145883 )) and ((j.from_date <= 1740347152 and j.to_date >= 1740347152 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 3237) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316145883 and j.to_ip >=316145883 )) and ((j.from_date <= 1740347152 and j.to_date >= 1740347152 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 3237)
      890μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1014 and `b`.`banner_from_date` <= 1740347152 and `b`.`banner_to_date` >= 1740347152 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.48msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1014
      • 3: 1740347152
      • 4: 1740347152
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4b512c32848a382e86350a943f1bb712'
      290μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        lAoRv3bsjbKyLzcNMo547uMrhJVqhVOv8yuDGTvB
        uc_cart_id
        4b512c32848a382e86350a943f1bb712
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/3237" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/3237
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6InNCOTFTeDI0U3p2eHVaSTk4MTkxaWc9PSIsInZhbHVlIjoiQWNMMkZiUVQ3Y3RIUWY1Z2IvU2EyOWRYWks2a0pQRHhDcVFCYWlCTGJGRT0iLCJtYWMiOiJmM2MzM2NlNzUzNjcyMzFkNDMwZjA2YmJiNDA4NGRiNTU3MGI0ZmMxODUyMWVhMWM1OWQ0NzY4ZjY2ZDNlMDBkIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6InNCOTFTeDI0U3p2eHVaSTk4MTkxaWc9PSIsInZhbHVlIjoiQWNMMkZiUVQ3Y3RIUWY1Z2IvU2EyOWRYWks2a0pQRHhDcVFCYWlCTGJGRT0iLCJtYWMiOiJmM2MzM2NlNzUzNjcy" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:45:52 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ikg1NHZVWDVJLzhPS0J6YmxTbE96M2c9PSIsInZhbHVlIjoiMmQ5VnhlY3NrTlNmZUNyM1Z2NU05YkRwNUpTZVBPNXdBRDJGRTh3VWZQWDQ1bzljbXJ4L2t4RXMrNW5mNmtZS0hWNTJGYVlYejdaYThTL25xVXlJaVFjZUNxWDJGcHZQNk82ZFZldjZTZlJxVmh3UjBwUm96a21TZ0VrTHNId3oiLCJtYWMiOiJjMDYyNzQyZDliNzgzNTNkNGY4ZmIzOWMyNjQ2M2QzMjI3NmNlNWJhY2UwNWIyZmJiMjdjMjIwNmQwZWM0YTE1IiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:45:52 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ikg1NHZVWDVJLzhPS0J6YmxTbE96M2c9PSIsInZhbHVlIjoiMmQ5VnhlY3NrTlNmZUNyM1Z2NU05YkRwNUpTZVBPNXdBRDJGRTh3VWZQWDQ1bzljbXJ4L2t4RXMrNW5mNmtZS0hWNTJGY" 1 => "alphaeurekaselectnet_session=eyJpdiI6IllkSnZaYzgraXFORVJndzNZU0o5R1E9PSIsInZhbHVlIjoiYUxNLzhVeFord0FIOFg0Z0NRRk1ZRWxIdWZZZkRpN0NweE9XWHg0cmR6RHIrSTJkME9KeVJtaE9WckFQc0VWRkdYcWd6TmsvK0lWVW45UXlpanJGcmJXMm9tT0djdlFOUkNUZVNrN3E3LzUzN1NGUS9DMWI5c3krNU12dGVrN1EiLCJtYWMiOiIwMDJiMzBlYTgyY2YxNGE0NDY3ZThlMDA2MWQ3NWZhZGMwMDA2ZGRhZDYyNDg2NzVlYTkxMzA0YjI1MjcwMWQ5IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IllkSnZaYzgraXFORVJndzNZU0o5R1E9PSIsInZhbHVlIjoiYUxNLzhVeFord0FIOFg0Z0NRRk1ZRWxIdWZZZkRpN0NweE9XWHg0cmR6RHIrSTJkME9KeVJtaE9" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ikg1NHZVWDVJLzhPS0J6YmxTbE96M2c9PSIsInZhbHVlIjoiMmQ5VnhlY3NrTlNmZUNyM1Z2NU05YkRwNUpTZVBPNXdBRDJGRTh3VWZQWDQ1bzljbXJ4L2t4RXMrNW5mNmtZS0hWNTJGYVlYejdaYThTL25xVXlJaVFjZUNxWDJGcHZQNk82ZFZldjZTZlJxVmh3UjBwUm96a21TZ0VrTHNId3oiLCJtYWMiOiJjMDYyNzQyZDliNzgzNTNkNGY4ZmIzOWMyNjQ2M2QzMjI3NmNlNWJhY2UwNWIyZmJiMjdjMjIwNmQwZWM0YTE1IiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:45:52 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ikg1NHZVWDVJLzhPS0J6YmxTbE96M2c9PSIsInZhbHVlIjoiMmQ5VnhlY3NrTlNmZUNyM1Z2NU05YkRwNUpTZVBPNXdBRDJGRTh3VWZQWDQ1bzljbXJ4L2t4RXMrNW5mNmtZS0hWNTJGY" 1 => "alphaeurekaselectnet_session=eyJpdiI6IllkSnZaYzgraXFORVJndzNZU0o5R1E9PSIsInZhbHVlIjoiYUxNLzhVeFord0FIOFg0Z0NRRk1ZRWxIdWZZZkRpN0NweE9XWHg0cmR6RHIrSTJkME9KeVJtaE9WckFQc0VWRkdYcWd6TmsvK0lWVW45UXlpanJGcmJXMm9tT0djdlFOUkNUZVNrN3E3LzUzN1NGUS9DMWI5c3krNU12dGVrN1EiLCJtYWMiOiIwMDJiMzBlYTgyY2YxNGE0NDY3ZThlMDA2MWQ3NWZhZGMwMDA2ZGRhZDYyNDg2NzVlYTkxMzA0YjI1MjcwMWQ5IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IllkSnZaYzgraXFORVJndzNZU0o5R1E9PSIsInZhbHVlIjoiYUxNLzhVeFord0FIOFg0Z0NRRk1ZRWxIdWZZZkRpN0NweE9XWHg0cmR6RHIrSTJkME9KeVJtaE9" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "lAoRv3bsjbKyLzcNMo547uMrhJVqhVOv8yuDGTvB" "uc_cart_id" => "4b512c32848a382e86350a943f1bb712" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/3237" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:45:52GET/chapter/3237112193