MicroRNAs and Cardiovascular Disease

miRNAs in Myocardial Infarction

Author(s): Zhiguo Wang

Pp: 47-51 (5)

DOI: 10.2174/978160805184711001010047

* (Excluding Mailing and Handling)

Abstract

The aim of this chapter is to provide an overview on the role of miRNAs in myocardial ischemia, ischemia/reperfusion injury and ischemic preconditioning. Myocardial ischemia due to occlusion of coronary arteries constitutes the major cause of mortality and morbidity of humans worldwide by causing an array of injuries. Timely myocardial reperfusion remains the most effective treatment strategy for reducing myocardial infarct size, preventing left ventricular remodelling, preserving left ventricular systolic function and improving clinical outcomes. However, the full benefits of myocardial reperfusion are not realized, given that the actual process of reperfusing ischemic myocardium can independently induce myocardial injury. On the other hand, heart has endogenous cardioprotective capability against myocardial/reperfusion injury, called ischemic preconditioning. Recent studies indicate that miRNAs are implicated in all these different aspects of myocardial ischemia. This chapter describes the role of miR-1 and mR-133 in myocardial ischemia, miR-21, miR-29 and miR-320 in ischemia/reperfusion injury, and miR-21 and miR-199a in preconditioning.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314530707 and j.to_ip >=314530707 )) and ((j.from_date <= 1740346992 and j.to_date >= 1740346992 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 3226) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314530707 and j.to_ip >=314530707 )) and ((j.from_date <= 1740346992 and j.to_date >= 1740346992 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 3226) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314530707 and j.to_ip >=314530707 )) and ((j.from_date <= 1740346992 and j.to_date >= 1740346992 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 3226)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 1014 and `b`.`banner_from_date` <= 1740346992 and `b`.`banner_to_date` >= 1740346992 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.08msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 1014
      • 3: 1740346992
      • 4: 1740346992
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='45897803b4d6873905762b3dd97fd652'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        MI0Kraqc4J31YFSP00s03rLGrFES1bPr4HYlp6Cb
        uc_cart_id
        45897803b4d6873905762b3dd97fd652
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/3226" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/3226
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IlJseUhxVGMrQWlSbnRIUFBIcy96amc9PSIsInZhbHVlIjoiY2dzdTMzT0NFMkRNd3B1VFJEQ3I0S25tMEc5cmJ2aWNFTE9yTWQxWkV0TT0iLCJtYWMiOiIyYmRhOWE1NzI2YzBiMWY5MzliNTIwZjcyODgxYTI0YmVlNWM1OTE0ODU0MTMxODU1ODYyODlkOTkxYmExNjg3IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IlJseUhxVGMrQWlSbnRIUFBIcy96amc9PSIsInZhbHVlIjoiY2dzdTMzT0NFMkRNd3B1VFJEQ3I0S25tMEc5cmJ2aWNFTE9yTWQxWkV0TT0iLCJtYWMiOiIyYmRhOWE1NzI2YzBi" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:43:12 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlMxdTNMbFA3bUJwekdiT1NNUVdSa1E9PSIsInZhbHVlIjoiNmN5Q2VodUpmVk16aHh6RFBUN3NlN1lpQ2xaZFdKSEljc2lyaWdiTXE1V1pQK2NVUFZBKzRTUGlvSmIvOURSZGg2VC9JZWZlcWJaQnFoNHJUTjVzYzA3NmJacFVhak9MNDJ2b1VjRUYzZHFLa3YwYXVlb0ZneGNLMkZXWXE3bXgiLCJtYWMiOiI0YTk3ODBkYjBhZTgzYzMxMzYwZTYzYjU1ZWFmZjMxZDRhMmZiYjhjYTUzZTY1MjY2MWZhY2E1NTY4M2ViMzI5IiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:43:12 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IlMxdTNMbFA3bUJwekdiT1NNUVdSa1E9PSIsInZhbHVlIjoiNmN5Q2VodUpmVk16aHh6RFBUN3NlN1lpQ2xaZFdKSEljc2lyaWdiTXE1V1pQK2NVUFZBKzRTUGlvSmIvOURSZGg2VC9JZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjRnU3JHbzhVdXl5SUIzL0lBYmx2QlE9PSIsInZhbHVlIjoiVENyUllXM1hDYUt1MWNwdkF5elVVK3MxRU5uTVFsK1JVNnNRSU03Tlc5NHFFTmdmZ2JOSmlSckJSQTAveXVIZ284R25WTTczaWkwRW1sWnV4TTU2NERTOXI4dFJOdElNL2hlZ0hzUjJYMEVDS2tUOE10Q1JhSnYyN05EeVZFV1QiLCJtYWMiOiJlMTNmMTE3NDYwZjNlNDFkODc3YjMzMWZjYWQ1NDIwMWI0NDBjYzFhZGQ4YmNlNmNiOWY2YTdkOTZkOGE3MmIyIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjRnU3JHbzhVdXl5SUIzL0lBYmx2QlE9PSIsInZhbHVlIjoiVENyUllXM1hDYUt1MWNwdkF5elVVK3MxRU5uTVFsK1JVNnNRSU03Tlc5NHFFTmdmZ2JOSmlSckJ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IlMxdTNMbFA3bUJwekdiT1NNUVdSa1E9PSIsInZhbHVlIjoiNmN5Q2VodUpmVk16aHh6RFBUN3NlN1lpQ2xaZFdKSEljc2lyaWdiTXE1V1pQK2NVUFZBKzRTUGlvSmIvOURSZGg2VC9JZWZlcWJaQnFoNHJUTjVzYzA3NmJacFVhak9MNDJ2b1VjRUYzZHFLa3YwYXVlb0ZneGNLMkZXWXE3bXgiLCJtYWMiOiI0YTk3ODBkYjBhZTgzYzMxMzYwZTYzYjU1ZWFmZjMxZDRhMmZiYjhjYTUzZTY1MjY2MWZhY2E1NTY4M2ViMzI5IiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:43:12 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IlMxdTNMbFA3bUJwekdiT1NNUVdSa1E9PSIsInZhbHVlIjoiNmN5Q2VodUpmVk16aHh6RFBUN3NlN1lpQ2xaZFdKSEljc2lyaWdiTXE1V1pQK2NVUFZBKzRTUGlvSmIvOURSZGg2VC9JZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjRnU3JHbzhVdXl5SUIzL0lBYmx2QlE9PSIsInZhbHVlIjoiVENyUllXM1hDYUt1MWNwdkF5elVVK3MxRU5uTVFsK1JVNnNRSU03Tlc5NHFFTmdmZ2JOSmlSckJSQTAveXVIZ284R25WTTczaWkwRW1sWnV4TTU2NERTOXI4dFJOdElNL2hlZ0hzUjJYMEVDS2tUOE10Q1JhSnYyN05EeVZFV1QiLCJtYWMiOiJlMTNmMTE3NDYwZjNlNDFkODc3YjMzMWZjYWQ1NDIwMWI0NDBjYzFhZGQ4YmNlNmNiOWY2YTdkOTZkOGE3MmIyIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjRnU3JHbzhVdXl5SUIzL0lBYmx2QlE9PSIsInZhbHVlIjoiVENyUllXM1hDYUt1MWNwdkF5elVVK3MxRU5uTVFsK1JVNnNRSU03Tlc5NHFFTmdmZ2JOSmlSckJ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "MI0Kraqc4J31YFSP00s03rLGrFES1bPr4HYlp6Cb" "uc_cart_id" => "45897803b4d6873905762b3dd97fd652" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/3226" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:43:12GET/chapter/3226112193