Abstract
Recent progress in genetics research has accelerated our comprehension of
complex disorders such as type 2 Diabetes Mellitus and breast cancer. Genome-wide
association studies on a large scale have facilitated our exploration of the underlying
pathology. Individuals with type 2 diabetes are at a higher risk of developing several
types of cancer as a result of common risk factors, such as obesity, poor diet, aging,
and low levels of physical activity. While several susceptibility genes have been
identified, we must consider tissue specificity and direction of effect when
investigating the shared genetic aetiology. Techniques such as Mendelian
randomisation allow us to unravel the link between the two diseases and answer critical
questions. By deconstructing the type 2 Diabetes GRS and studying genetic variants in
relation to their biological function, we may be able to evaluate the causal association
between different groups and various cancer types. Genetic research also has the
potential to investigate epigenetic modifications that contribute to the development of
cancer. This work explores the association between the genetic similarity between type
2 diabetes and breast cancer.