Stem Cells in Clinical Application and Productization

Biomaterials and Stem Cells

Author(s): Leisheng Zhang*, Xiaodong Xu, Rucai Zhan, Shuang Chen, Shixun Ma, Yuanguang Zhao, Zhihai Han, Xianghong Xu, Yonghong Li, Miao Yu, Tiankang Guo, Hui Cai, Hao Yao* and Ping Wang * .

Pp: 18-28 (11)

DOI: 10.2174/9789815196627124010005

* (Excluding Mailing and Handling)

Abstract

Longitudinal studies have indicated the involvement and performance of multitudinous biomaterials for stem cell-based cytotherapy and regenerative medicine largely attribute to their specific biocompatibility. Currently, stem cells and biomaterial scaffolds have been considered as the two essential elements of the cornerstone of tissue engineering. On the one hand, biomaterials are beneficial to provide suitable microenvironments for enhancing the cellular vitality and therapeutic effect of stem cells. On the other hand, biomaterial-induced fibrosis and inflammation remain a prominent challenge in designing and synthesizing appropriate materials to facilitate tissue repair and organ regeneration. In this book chapter, we summarize the classification and physicochemical properties of the indicated biomaterials, and appraise the latest literatures of biomaterial and stem cell composite for broad biomedical applications in tissue engineering and regenerative medicine. Collectively, we retrospect the current advancement of biomaterial engineering and science, and highlight the multifaceted biomaterial-assisted stem cell-based tissue engineering and regenerative medicine, and in particular, the biomaterial-based composites with mesenchymal stem/stromal cells (MSCs) and the derivatives (e.g., exosomes, small microvesicles) for intractable disease administration.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51638174 and j.to_ip >=51638174 )) and ((j.from_date <= 1739834428 and j.to_date >= 1739834428 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 21642) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51638174 and j.to_ip >=51638174 )) and ((j.from_date <= 1739834428 and j.to_date >= 1739834428 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 21642) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51638174 and j.to_ip >=51638174 )) and ((j.from_date <= 1739834428 and j.to_date >= 1739834428 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 21642)
      500μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3670 and `b`.`banner_from_date` <= 1739834428 and `b`.`banner_to_date` >= 1739834428 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.03msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3670
      • 3: 1739834428
      • 4: 1739834428
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='141d4abd2f3247e3bef8aabffa976cc6'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        7pAfuAII8g5yAyaswip6ii3z04e85tPGUDKdlRmG
        uc_cart_id
        141d4abd2f3247e3bef8aabffa976cc6
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/21642" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/21642
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IklKSEtsOFpUczBrWCtkOTRYeDgzL2c9PSIsInZhbHVlIjoiMThEOTVpVXdQNGtiZEFpTXJYRGdNd1htNkYySVlscHRDSDM5NzV1MkZYckdrd3F3UWtXZ29HdThENEpacHFqZiIsIm1hYyI6IjU0YmYxMGVlYWJmNjU2MmFmNmYxZmI1NGJlZWEyZDIyZGUzYjgyNGNhZWY0ZTBiZWZhMTE1YjJjYjE3YjkzOTkiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6IlZ1QUUwNmloNGVHL2lVRUd6a0ZxcEE9PSIsInZhbHVlIjoic0REWmlVeDRsOWlXdjZhSlhSaVVVdWdHR1NJcXNvcW0zaUZTMkdwUHV3dzZsQmVzbjFSaU81akFzdmdQVDZJZUpjU0tnb1ZNUThzTjNiV2FKQ09oRS9lZWx3dk15VURqcmJLSjdGNGRRU3p5eTZteFdITS9MaitmUTF4ZFhsT3giLCJtYWMiOiIzMzE5MmVkM2MyZGRhYWRhMjFiOWQ4NWMwZGU3NzY3MTk3Y2RkZTMwYWM5YmUxOGEwNGYyZTdiNzgyM2QzYjMxIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6ImJnQnlzWDM4QUpLSkExUGZ2dFhCQWc9PSIsInZhbHVlIjoiSm1GcUxUWXUwSk1wVU90QU91cTJPdThYY0gxR2cySGg3eFJpU3QzOG5ibEE4em5qbGJzK0FoYjJ5WjBpeVJmc0JkUVdsWm1HMFVHamJXWWw3Um1pOU9mQVd5YStuOFhvZEU5a2EybHZtM2d0L1ZtVllhNTVYUGxCVjd1MnA4WnUiLCJtYWMiOiJkOWZiMWZlY2E1YWFlYzQ1MTEwMDlmN2ZiOGZhNWU2YzU3MzAwNGZlMTlmMmMyMTQyMGIwMmRiZmNiYmM5Y2NmIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IklKSEtsOFpUczBrWCtkOTRYeDgzL2c9PSIsInZhbHVlIjoiMThEOTVpVXdQNGtiZEFpTXJYRGdNd1htNkYySVlscHRDSDM5NzV1MkZYckdrd3F3UWtXZ29HdThENEpacHFqZiIs" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "7pAfuAII8g5yAyaswip6ii3z04e85tPGUDKdlRmG" "uc_cart_id" => "141d4abd2f3247e3bef8aabffa976cc6" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/21642" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:20:28GET/chapter/21642112192