Applied Biomathematics for Nucleic Acid Chemistry and Protein Folding: Quantitative Simulations

A Monte Carlo Assisted Simulation of Stochastic Molecular Dynamics for Folding of the Protein Crambin in a Viscous Environment

Author(s): Sencer Taneri * .

Pp: 26-45 (20)

DOI: 10.2174/9789815179965123010006

* (Excluding Mailing and Handling)

Abstract

 In Chapter 3, we investigate the folding dynamics of the plant-seed protein Crambin in a liquid environment, that usually happens to be water with some certain viscosity. To take into account the viscosity, necessitates a stochastic approach. This can be summarized by a 2D-Langevin equation, even though the simulation is still carried out in 3D. Solution of the Langevin equation will be the basic task in order to proceed with a Molecular Dynamics simulation, which will accompany a delicate Monte Carlo technique. The potential wells, used to engineer the energy space assuming the interaction of monomers constituting the protein-chain, are simply modeled by a combination of two parabola. This combination will approximate the real physical interactions, that are given by the well known Lennard-Jones potential. Contributions to the total potential from torsion, bending and distance dependent potentials are good to the fourth nearest neighbor. The final image is in very good geometric agreement with the real shape of the protein chain, which can be obtained from the protein data bank. The quantitative measure of this agreement is the similarity parameter with the native structure, which is found to be 0.91 < 1 for the best sample. The folding time can be determined from Debye-relaxation process. We apply two regimes and calculate the folding time, corresponding to the elastic domain mode, which yields 5.2ps for the same sample. 

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version234msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[03:13:15] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (129ms)time
  • Application (105ms)time
  • 1 x Booting (55.25%)
    129ms
    1 x Application (44.75%)
    105ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed38.99ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316604151','',1,1739848395,1739848395) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739848395
      920μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316604151','/chapter/20976',1,1739848395,1739848395)
      210μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316604151 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316604151) limit 1
      26.47msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316604151
      • 1: 316604151
      • 2: 316604151
      • 3: 316604151
      • 4: 316604151
      • 5: 316604151
      • 6: 316604151
      • 7: 316604151
      • 8: 316604151
      • 9: 316604151
      • 10: 316604151
      • 11: 316604151
      • 12: 316604151
      • 13: 316604151
      • 14: 316604151
      • 15: 316604151
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '20976' limit 1
      410μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 20976
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '20976' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.76msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 20976
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '20976'
      290μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 20976
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 1259 limit 1
      370μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 1259
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1259) and se.ebook_id!=1259 and v.ebook_status='1'
      2.36msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1259) and se.ebook_id!=1259 and v.ebook_status='1' limit 10 offset 0
      780μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1259)
      440μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1259) limit 10 offset 0
      480μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 3625 and `e`.`is_uploaded` = 1
      500μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 3625
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 1259 and ebook_volume_id <> 3625 limit 1
      300μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 1259
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '20976' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      310μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '3625' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739848395 and j.to_date >= 1739848395 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3625) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739848395 and j.to_date >= 1739848395 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3625) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739848395 and j.to_date >= 1739848395 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3625)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739848395 and j.to_date >= 1739848395 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20976) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739848395 and j.to_date >= 1739848395 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20976) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739848395 and j.to_date >= 1739848395 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20976)
      660μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3625 and `b`.`banner_from_date` <= 1739848395 and `b`.`banner_to_date` >= 1739848395 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.61msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3625
      • 3: 1739848395
      • 4: 1739848395
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='f39fe6dbf2c44658ec7e690f647b9680'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        b6KPQQw4OC5iHAxCajJNJZ5IQlVxldn9HJ7lZK5g
        uc_cart_id
        f39fe6dbf2c44658ec7e690f647b9680
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/20976" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/20976
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:16 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 18 Feb 2025 03:13:15 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkVBQkxDZ0VZWWx6V3ZpdnQ1WlE5UFE9PSIsInZhbHVlIjoiTkp1R2Rackt2QVdOQTl5NWZwSXM4b1o4ZEkzaEtMdlFwcHhGNGMyS2tQT005eHdkWTZzZFVXV1Q5L0NnUzFBM1A0aGNsWkdSUXNnRzhFdm5zZlNYa09SQzRxM2xsTkRURGM3c3pNUSszR1FTczMwRWIrdEdCY1NiZmNVZitjUlIiLCJtYWMiOiIyM2FkODRhYTk5YTI5MmQ3ZTc0NDViNWZlMjVjNWZmMjRkNzc3M2E0NGI4MDQ2NWI2YzEwZjBjMzlkZjljYjk3IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 15:13:15 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkVBQkxDZ0VZWWx6V3ZpdnQ1WlE5UFE9PSIsInZhbHVlIjoiTkp1R2Rackt2QVdOQTl5NWZwSXM4b1o4ZEkzaEtMdlFwcHhGNGMyS2tQT005eHdkWTZzZFVXV1Q5L0NnUzFBM1A0aGNsW" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlJ4eXF4Uy9BblY1MUpPQXlVNFRzZGc9PSIsInZhbHVlIjoiQ1ZERUg5RmdQNjY4MitLbkNuV1R6dWxzUU1mdzc4cHdaZHkyb2xMZjhYR2R1QmJ6a0VWaDFqTWhWSU1XUUJpa0poZ1k0NkVJUXZGNlJKRGZxMUJOdW96VkpqWDQyRUNvbmtQSHEvNkJVK0hmK2pocWlXVHU5cExHRG5Od29acGEiLCJtYWMiOiJhYzQ5NmYwNmU3ZjcwMjdkM2U4MjVjMmViNjRjM2U1NDU0MzU5ZWVmNmQzNTRiOTc1YWQ1OTgwYWEzODU4YWI2IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IlJ4eXF4Uy9BblY1MUpPQXlVNFRzZGc9PSIsInZhbHVlIjoiQ1ZERUg5RmdQNjY4MitLbkNuV1R6dWxzUU1mdzc4cHdaZHkyb2xMZjhYR2R1QmJ6a0VWaDFqTWh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkVBQkxDZ0VZWWx6V3ZpdnQ1WlE5UFE9PSIsInZhbHVlIjoiTkp1R2Rackt2QVdOQTl5NWZwSXM4b1o4ZEkzaEtMdlFwcHhGNGMyS2tQT005eHdkWTZzZFVXV1Q5L0NnUzFBM1A0aGNsWkdSUXNnRzhFdm5zZlNYa09SQzRxM2xsTkRURGM3c3pNUSszR1FTczMwRWIrdEdCY1NiZmNVZitjUlIiLCJtYWMiOiIyM2FkODRhYTk5YTI5MmQ3ZTc0NDViNWZlMjVjNWZmMjRkNzc3M2E0NGI4MDQ2NWI2YzEwZjBjMzlkZjljYjk3IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 15:13:15 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkVBQkxDZ0VZWWx6V3ZpdnQ1WlE5UFE9PSIsInZhbHVlIjoiTkp1R2Rackt2QVdOQTl5NWZwSXM4b1o4ZEkzaEtMdlFwcHhGNGMyS2tQT005eHdkWTZzZFVXV1Q5L0NnUzFBM1A0aGNsW" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlJ4eXF4Uy9BblY1MUpPQXlVNFRzZGc9PSIsInZhbHVlIjoiQ1ZERUg5RmdQNjY4MitLbkNuV1R6dWxzUU1mdzc4cHdaZHkyb2xMZjhYR2R1QmJ6a0VWaDFqTWhWSU1XUUJpa0poZ1k0NkVJUXZGNlJKRGZxMUJOdW96VkpqWDQyRUNvbmtQSHEvNkJVK0hmK2pocWlXVHU5cExHRG5Od29acGEiLCJtYWMiOiJhYzQ5NmYwNmU3ZjcwMjdkM2U4MjVjMmViNjRjM2U1NDU0MzU5ZWVmNmQzNTRiOTc1YWQ1OTgwYWEzODU4YWI2IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IlJ4eXF4Uy9BblY1MUpPQXlVNFRzZGc9PSIsInZhbHVlIjoiQ1ZERUg5RmdQNjY4MitLbkNuV1R6dWxzUU1mdzc4cHdaZHkyb2xMZjhYR2R1QmJ6a0VWaDFqTWh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "b6KPQQw4OC5iHAxCajJNJZ5IQlVxldn9HJ7lZK5g" "uc_cart_id" => "f39fe6dbf2c44658ec7e690f647b9680" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/20976" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-18 03:13:15GET/chapter/20976112192