Abstract
Acne vulgaris is one of the most skin diseases related to the sebaceous
gland, characterized by multiple pathogenic factors. The treatment strategies involve
the blockage of these pathological factors. Conventional therapies for the treatment of
Acne vulgaris in controlling its pathological factors are still inadequate in providing
therapeutic effectiveness and exhibit remarkable side effects. New therapeutic agent
development for acne treatment is still stagnant. Recently, researchers have been
focusing and seeking great interest in the treatment of acne through natural products –
as a new therapeutic option. In this regard, multiple natural products have been
evaluated for their potential to treat acne, including berberine, α-mangostin, curcumin,
ampelopsin, fustin, ellagic acid, gallic acid, myricetin, lupeol and many more. These
natural products have been reported as suitable candidates for blocking multiple
pathogenic factors associated with acne. In addition, the nanotechnology-based
delivery of natural products is a new platform and treatment option for Acne vulgaris.
Natural products nano-based delivery resolves many other issues concerned with
natural products apart from treatment aid. Natural products, therefore, pose a precious
source in determining new agents for the treatment of acne. However, reported studies
are preclinical, and to obtain reliable and conclusive results, further clinical studies are
required to uplift natural products from bench top to clinical setup in treating the worst
consequences of Acne vulgaris.