Abstract
New diagnostic technologies are paper-based sensors that are
multifunctional, highly flexible, absorbent, and environmentally friendly. The substrate
can be used to design a cost-effective framework for disease detection, prognosis, and
surveillance of illnesses that is easy, reliable, and quick in our medical healthcare
sector. Paper-based devices are an extremely cheap innovation for fabricating
simplified and movable diagnosing processes that can be extremely useful in resource-constrained settings like developing countries, where fully equipped infrastructure and
highly skilled medical persons are unavailable. Point-of-care (POC) devices give a
significant advantage over traditional procedures for in-situ measurement of illness or
disease biomarkers, assisting physicians in making decisions. Paper-based analytical
devices that combine paper substrates have become popular point-of-need diagnostics
over the last decade. We discuss in this chapter the paper-based analytical biosensors
and the classification of paper-based biosensors (PBBs) as Dipstick tests, lateral flow
assay (LFAs), microfluidic biosensors, and biosensor devices (transducers and
biorecognition elements). Furthermore, paper-based biosensors are used to detect
malaria and other diseases.