Recent Advances in Biosensor Technology

Volume: 2

The Emerging Role of Biosensors in the Identification, Characterization, and use of Natural Bioactive Compounds

Author(s): Abhay Dev Tripathi, Vivek Kumar Pandey, Soumya Katiyar and Abha Mishra * .

Pp: 1-15 (15)

DOI: 10.2174/9789815136418123020005

* (Excluding Mailing and Handling)

Abstract

High specificity, less reagent requirement, swift response time, and high throughput screening make biosensors popular for detecting disease biomarkers, monitoring diseases, drug discovery, and other ecological applications such as the detection of environmental pollutants. Emerging health disorders demand targeted drugs with lower side effects in terms of advancing towards a low medicinal load. Active ingredients present in the different parts of plants and microorganisms have been used for several medical purposes for ages. Recent research has identified multiple promising natural bioactive compounds possessing the potential to mitigate several life-threatening diseases like Cancer, Diabetes, and Neurological disorders. Identifying such bioactive chemicals in the crude extract from various plant sources like leaves, roots, bark, fruits, and seeds, as well as in microbial extracts, is a tedious work that requires complex instrument setups, lengthy methods, and plenty of time, sometimes many years. The development and use of biosensors for natural bioactive moieties can overcome such problems and expedite the drug discovery process. This chapter provides a summary of the available biosensors for bioactive chemicals detection in extracts and fractions of organisms/plants, their types, design, and methods used for that purpose. Moreover, the chapter highlights the current use and the progress of the development of biosensors for identifying bioactive natural compounds. 

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739959261 and j.to_date >= 1739959261 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20266) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739959261 and j.to_date >= 1739959261 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20266) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316604151 and j.to_ip >=316604151 )) and ((j.from_date <= 1739959261 and j.to_date >= 1739959261 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 20266)
      710μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3575 and `b`.`banner_from_date` <= 1739959261 and `b`.`banner_to_date` >= 1739959261 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.2msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3575
      • 3: 1739959261
      • 4: 1739959261
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='e722969d49c2f8ff3784e786c7d1dfdc'
      340μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        DrRO0uW9eqVpquXdHIV4VrVu4Q2858RwyEKzZLkJ
        uc_cart_id
        e722969d49c2f8ff3784e786c7d1dfdc
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/20266" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/20266
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:16 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 10:01:01 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InpsUVNoNHpPMGdXcWI3bC82dXZBRHc9PSIsInZhbHVlIjoiQTI3QjBiWml3eWNtS1dsTWVEUG1lQ05WQjQyVHNaWU5GbFcrbGpsSktJalUvOG9WSkZFNWdRMHhpSDZLeUcwVXNpSWlWb1pGS1hkbm1QT2RGaUxiU1BSTlRqMG5iUzJ0YWszaUs4Vk4xRXVjeGFjNDhIY0VCeXREblNLQnhOeWwiLCJtYWMiOiJkNjk1ZjQ3YjVjMjNjYmYxZDM3ZmQxNjI5ZGI2MTlkZjBjZDg3MmNkNzQ4YzhmOTZiZGUyZDkxMzU3ODRmMGE4IiwidGFnIjoiIn0%3D; expires=Fri, 21 Feb 2025 22:01:01 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InpsUVNoNHpPMGdXcWI3bC82dXZBRHc9PSIsInZhbHVlIjoiQTI3QjBiWml3eWNtS1dsTWVEUG1lQ05WQjQyVHNaWU5GbFcrbGpsSktJalUvOG9WSkZFNWdRMHhpSDZLeUcwVXNpSWlWb" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZGWW9SY2JRRm5EandCajN0TWsyTHc9PSIsInZhbHVlIjoiMHpHL2w0SUJqOVllbEI2SXNxSjFQRVFzaUdHVVBvcGNjODNFZ3YxY1ZYeEFzUVFRKzNkc3VxYmVXV2NxQnM1RkcxWSswSTQ4TkE5U2NncFFXeWdzWHJKeFljMWtMcnUzeGNFOFRlK2oyY0dCNzU3SHBZaWRjMmVwRVJqNVoyZFUiLCJtYWMiOiI2ZjBjZDIwNjkzOGQ4Y2ZjYjBiOTljMGU0YTYzODhkMWVjMmJlMGRlZWU5YzExMWUyZWU5ZWIyNDkxMmRiZmIzIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjZGWW9SY2JRRm5EandCajN0TWsyTHc9PSIsInZhbHVlIjoiMHpHL2w0SUJqOVllbEI2SXNxSjFQRVFzaUdHVVBvcGNjODNFZ3YxY1ZYeEFzUVFRKzNkc3VxYmV" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InpsUVNoNHpPMGdXcWI3bC82dXZBRHc9PSIsInZhbHVlIjoiQTI3QjBiWml3eWNtS1dsTWVEUG1lQ05WQjQyVHNaWU5GbFcrbGpsSktJalUvOG9WSkZFNWdRMHhpSDZLeUcwVXNpSWlWb1pGS1hkbm1QT2RGaUxiU1BSTlRqMG5iUzJ0YWszaUs4Vk4xRXVjeGFjNDhIY0VCeXREblNLQnhOeWwiLCJtYWMiOiJkNjk1ZjQ3YjVjMjNjYmYxZDM3ZmQxNjI5ZGI2MTlkZjBjZDg3MmNkNzQ4YzhmOTZiZGUyZDkxMzU3ODRmMGE4IiwidGFnIjoiIn0%3D; expires=Fri, 21-Feb-2025 22:01:01 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InpsUVNoNHpPMGdXcWI3bC82dXZBRHc9PSIsInZhbHVlIjoiQTI3QjBiWml3eWNtS1dsTWVEUG1lQ05WQjQyVHNaWU5GbFcrbGpsSktJalUvOG9WSkZFNWdRMHhpSDZLeUcwVXNpSWlWb" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZGWW9SY2JRRm5EandCajN0TWsyTHc9PSIsInZhbHVlIjoiMHpHL2w0SUJqOVllbEI2SXNxSjFQRVFzaUdHVVBvcGNjODNFZ3YxY1ZYeEFzUVFRKzNkc3VxYmVXV2NxQnM1RkcxWSswSTQ4TkE5U2NncFFXeWdzWHJKeFljMWtMcnUzeGNFOFRlK2oyY0dCNzU3SHBZaWRjMmVwRVJqNVoyZFUiLCJtYWMiOiI2ZjBjZDIwNjkzOGQ4Y2ZjYjBiOTljMGU0YTYzODhkMWVjMmJlMGRlZWU5YzExMWUyZWU5ZWIyNDkxMmRiZmIzIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjZGWW9SY2JRRm5EandCajN0TWsyTHc9PSIsInZhbHVlIjoiMHpHL2w0SUJqOVllbEI2SXNxSjFQRVFzaUdHVVBvcGNjODNFZ3YxY1ZYeEFzUVFRKzNkc3VxYmV" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "DrRO0uW9eqVpquXdHIV4VrVu4Q2858RwyEKzZLkJ" "uc_cart_id" => "e722969d49c2f8ff3784e786c7d1dfdc" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/20266" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 10:01:01GET/chapter/20266112192