Abstract
Nanotechnology is a greatly advancing field of scientific research due to its
largely untapped potential, which may apply to various clinical uses. This book chapter
focuses on the potential use of nanocollagen, graphene, and antibiotic components in
biomaterial fabrication for wound healing. Nanocollagen is simply regular collagen
broken down to the nanometer scale. Its nanocollagen-based biomaterials also conform
to the ideals of tissue engineering, which are excellent biocompatibility with a high
bioabsorption rate and little to no antigenicity while having an extensively cross-linked
structure suitable for cellular growth and metabolism. Nanocollagen can be fabricated
through electrospinning, nanolithography, self-assembly, and others. The physiology of
wound healing follows specific proceedings, which are haemostasis, inflammation, and
remodelling stages. The wound healing process may be improved through the use of
nanocollagen biomaterials, together with the addition of graphene and antibiotics.
Nanocollagen biomaterials aid in acting as a barrier for the wound against infections
while providing collagen in the nanoscale to accelerate healing. The addition of
antibiotics into the nanocollagen biomaterial aids in preventing bacterial infection by
the inhibition of biofilm formation. Graphene, specifically in its oxide form, also acts
as an antibacterial agent while potentially providing mechanical durability to the
biomaterial scaffold. Along with the benefits of graphene oxide application in wound
healing, its challenges are discussed in this book chapter. With that, this book chapter
suggests the beneficial combinatorial factors of nanocollagen, graphene, and antibiotics
that can potentially produce biomaterials with strong antibacterial properties while
accelerating wound healing.