Abstract
Chromosome 4 represents around 6 percent of the total DNA in the cell with 191 million DNA base pairs. Genetic changes in chromosome 4, such as somatic mutation, and chromosomal rearrangement like translocation, gene deletion, etc., have been reported to develop several types of cancer. This includes leukemias, multiple myeloma, oesophageal squamous cell carcinoma, prostate cancer, breast cancer, bladder cancer, etc. In this chapter, we have listed genes residing in chromosome 4, which further frequently support cancer development, progression, and metastasis.