Abstract
Microbial transformation is an effective tool for the structural modification of bioactive natural and synthetic compounds. Its application in asymmetric synthesis is increasing due to its versatility and ease. The present article reviews our contributions in the field of microbial transformation of different classes of bioactive natural products. The microbial transformation of monoterpenoids [(1R, 2S, 5R)-(-)-menthol and (-)-a-pinene], sesquiterpenoids [(+)-sclareolide, 7a-hydroxyfrullanolide, nootkatone, a-santonin, (-)-ambrox and isolongifolen-4-one], sapogenins (sarsasapogenin), alkaloids (vindoline) and steroids (E-guggulsterone, withaferin-A, (+)-adrenosterone, androst-1,4-dien-3,17- dione, dehydroepiandrosterone, norethisterone, 17a-ethynylestradiol, prednisone, testosterone and danazol) are described here along with biological activities of transformed products.
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Cite this chapter as:
Atta ur-Rahman, M. Iqbal Choudhary, S. Ghulam Musharraf ;Microbial Transformation of Natural Products- A Tool for the Synthesis of Novel Analogues of Bioactive Substances, Frontiers in Natural Product Chemistry (2005) 1: 133. https://doi.org/10.2174/978160805212710501010133
DOI https://doi.org/10.2174/978160805212710501010133 |
Print ISSN 1574-0897 |
Publisher Name Bentham Science Publisher |