Microcirculation and Insulin Resistance

Hemorheology in Insulin Resistance

Author(s): Jean-Frederic Brun, Emmanuelle Varlet-Marie, Ikram Aloulou, Mathieu Sardinoux, Eric Raynaud de Mauverger and Jacques Mercier

Pp: 99-106 (8)

DOI: 10.2174/978160805057410901010099

* (Excluding Mailing and Handling)

Abstract

The insulin resistance syndrome is associated with hemorheologic abnormalities whose understanding is complex, since rheological properties of plasma and blood cells are to a large extent determined by the surrounding milieu: physicochemical factors, metabolism and hormones. It is thus difficult to delineate the specific role of adiposity, endothelial dysfunction, and the hormonal disturbance by its own in this complex picture. Nevertheless, low insulin sensitivity which is associated with both increased body fat and increased circulating lipids, together with impaired fibrinolysis, is characterized by a mild hyperviscosity syndrome. Those rheological alterations are more closely related to insulin resistance than to the clinical scoring of the metabolic syndrome. Low insulin sensitivity is associated with increased erythrocyte aggregability. When low insulin sensitivity is associated with hyperinsulinemia there is an increase in plasma viscosity. Among those factors, plasma viscosity appears, in multivariate analysis, to be "independently" related to insulin resistance. Moreover, plasma hyperviscosity is corrected by insulin-sensitizing procedures (such as exercise training) and is thus to some extent a marker of this disease.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51632632 and j.to_ip >=51632632 )) and ((j.from_date <= 1740513689 and j.to_date >= 1740513689 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1914) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51632632 and j.to_ip >=51632632 )) and ((j.from_date <= 1740513689 and j.to_date >= 1740513689 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1914) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51632632 and j.to_ip >=51632632 )) and ((j.from_date <= 1740513689 and j.to_date >= 1740513689 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1914)
      860μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 924 and `b`.`banner_from_date` <= 1740513689 and `b`.`banner_to_date` >= 1740513689 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.07msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 924
      • 3: 1740513689
      • 4: 1740513689
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='1b98b211f94a069b6ff541366fdf6e46'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        jJ19tX3KAlMysTMzprzn9TUBCG6sBcehqghdpfxH
        uc_cart_id
        1b98b211f94a069b6ff541366fdf6e46
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1914" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/1914
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Ik1iSHJCQUx3bUxaSXJpQW5aYVpmVXc9PSIsInZhbHVlIjoiUGtNblRQZm4zcW5aS3ZVclQwQW5JdnlzdFBtRDJHYmdCTG0yelFRMXNJUT0iLCJtYWMiOiJmMTgwYTRhMTlkOTQzYjY5YTU4MjdhNmNmY2JhZWY4ODk1NzliODBlZmIzMWNkNDAyOGUyNmE1YzFmYzA1ZGU1IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Ik1iSHJCQUx3bUxaSXJpQW5aYVpmVXc9PSIsInZhbHVlIjoiUGtNblRQZm4zcW5aS3ZVclQwQW5JdnlzdFBtRDJHYmdCTG0yelFRMXNJUT0iLCJtYWMiOiJmMTgwYTRhMTlkOTQz" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 20:01:29 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkluTmQ0VEpJYnhOenNFMlM0cHVPbEE9PSIsInZhbHVlIjoidGs1QU9jWG9CaHU2Q3MxSTdwSTV3Qk0zNzArU3UzVHZ5dWczNEpVSjM2MlBRUTFab3lTRER4THMydFdvS1N3VTlHVzU0akR2Y2xVWUExcHBTNXNaZTE2MGYxUGIzRndXTXJWYnpzaTFraXVJTVNqMS8yeTVyVEpoc0dUQTE4RzIiLCJtYWMiOiJmNDJlMTQ5NDk5Y2UzMjdhMDQ2MDk1M2NhZGE4NjY2MzE2NTQ2ZjBhNTk3NDgxYzIzMDEwOGU5ZjBjZDRiZmIzIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 08:01:29 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkluTmQ0VEpJYnhOenNFMlM0cHVPbEE9PSIsInZhbHVlIjoidGs1QU9jWG9CaHU2Q3MxSTdwSTV3Qk0zNzArU3UzVHZ5dWczNEpVSjM2MlBRUTFab3lTRER4THMydFdvS1N3VTlHVzU0a" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ikl0cjJpUXpYODJpc29kLzBoY2JYR3c9PSIsInZhbHVlIjoiYXd3YTg3QUZnRWY5clVZRndxUXJDdnp0a3gxLytkUms4NG1pRDZHbzdKWlljRUhsajhQUm80SFFhWSt0dnNiN2tCUDB5VStMc05RdzRiMHVvdzhRcWRCUGZ4M0s2SitxMEJQalRxTlI4RktVMHdCeUc4SW5xbVBGcVpCNGhCcjUiLCJtYWMiOiIwY2ViMmUwNDc0MmYzN2ZiMjc1YTQ3MmVkNDkwNzJiNWRlNjhkMmE2ZjliNjdlZTZlNmYxYWRkZTE2Y2VjYzUwIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ikl0cjJpUXpYODJpc29kLzBoY2JYR3c9PSIsInZhbHVlIjoiYXd3YTg3QUZnRWY5clVZRndxUXJDdnp0a3gxLytkUms4NG1pRDZHbzdKWlljRUhsajhQUm80SFF" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkluTmQ0VEpJYnhOenNFMlM0cHVPbEE9PSIsInZhbHVlIjoidGs1QU9jWG9CaHU2Q3MxSTdwSTV3Qk0zNzArU3UzVHZ5dWczNEpVSjM2MlBRUTFab3lTRER4THMydFdvS1N3VTlHVzU0akR2Y2xVWUExcHBTNXNaZTE2MGYxUGIzRndXTXJWYnpzaTFraXVJTVNqMS8yeTVyVEpoc0dUQTE4RzIiLCJtYWMiOiJmNDJlMTQ5NDk5Y2UzMjdhMDQ2MDk1M2NhZGE4NjY2MzE2NTQ2ZjBhNTk3NDgxYzIzMDEwOGU5ZjBjZDRiZmIzIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 08:01:29 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkluTmQ0VEpJYnhOenNFMlM0cHVPbEE9PSIsInZhbHVlIjoidGs1QU9jWG9CaHU2Q3MxSTdwSTV3Qk0zNzArU3UzVHZ5dWczNEpVSjM2MlBRUTFab3lTRER4THMydFdvS1N3VTlHVzU0a" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ikl0cjJpUXpYODJpc29kLzBoY2JYR3c9PSIsInZhbHVlIjoiYXd3YTg3QUZnRWY5clVZRndxUXJDdnp0a3gxLytkUms4NG1pRDZHbzdKWlljRUhsajhQUm80SFFhWSt0dnNiN2tCUDB5VStMc05RdzRiMHVvdzhRcWRCUGZ4M0s2SitxMEJQalRxTlI4RktVMHdCeUc4SW5xbVBGcVpCNGhCcjUiLCJtYWMiOiIwY2ViMmUwNDc0MmYzN2ZiMjc1YTQ3MmVkNDkwNzJiNWRlNjhkMmE2ZjliNjdlZTZlNmYxYWRkZTE2Y2VjYzUwIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ikl0cjJpUXpYODJpc29kLzBoY2JYR3c9PSIsInZhbHVlIjoiYXd3YTg3QUZnRWY5clVZRndxUXJDdnp0a3gxLytkUms4NG1pRDZHbzdKWlljRUhsajhQUm80SFF" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "jJ19tX3KAlMysTMzprzn9TUBCG6sBcehqghdpfxH" "uc_cart_id" => "1b98b211f94a069b6ff541366fdf6e46" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1914" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 20:01:29GET/chapter/1914112193