Recent Trends and The Future of Antimicrobial Agents - Part I

Advent of Pharmabiotics as a Promising Therapeutic Tool for Human Health and Diseases Management

Author(s): Vanita Mulay, Dhanashri Satav, Austin Fernandes, Priyanka Pisalwar and Shadab Ahmed * .

Pp: 140-173 (34)

DOI: 10.2174/9789815079609123010008

* (Excluding Mailing and Handling)

Abstract

With the recent advances in understanding the role of the gut microbiome and human health, it has become evident that pharmabiotics have huge potential in the therapeutics as well as supplement industries for conditions leading to impaired microbiota. Pharmabiotics can be referred to as a class of microbial therapeutic probiotics which could be live bacterial cells of human origin or their products with clinically proven pharmacological activities found to be beneficial in human disease conditions. So, the mechanism by which bacteria produce synergistic beneficial effects on health could help us to develop a scheme to understand the delicate relationship between the gut microbiome and human health. In this chapter, we will emphasize the role of gut microbiota, the pharmabiotics they produce and how it affects different physiological and metabolic and host-microbe interactions leading to the production of bioactive chemicals with health benefits, eventually leading to the establishment of a healthy immune system. The chapter will also discuss the repercussions of disturbed gut microbiota on overall human health, including host psychiatric health. The fact that pharmabiotics acting as antimicrobial agents will produce no resistant variety is also an added bonus that increases the scope for discovery of such novel therapeutic agents.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1739834915 and j.to_date >= 1739834915 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 18674) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1739834915 and j.to_date >= 1739834915 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 18674) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1739834915 and j.to_date >= 1739834915 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 18674)
      520μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3465 and `b`.`banner_from_date` <= 1739834915 and `b`.`banner_to_date` >= 1739834915 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.06msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3465
      • 3: 1739834915
      • 4: 1739834915
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='b3aee4b309370e35934ff6a765108e20'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        9ehv1i2FRYOby8w2RGwcYhO5vH27JZuNcdrAxGiC
        uc_cart_id
        b3aee4b309370e35934ff6a765108e20
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/18674" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/18674
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
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        response_headers
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        session_attributes
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:28:35GET/chapter/18674112192