Indopathy for Neuroprotection: Recent Advances

Utilization of Nutraceuticals and Ayurvedic Drugs in the Management of Parkinson’s Disease

Author(s): Shilpa Negi and Sarika Singh * .

Pp: 337-350 (14)

DOI: 10.2174/9789815050868122010018

* (Excluding Mailing and Handling)

Abstract

Age-related degeneration of dopaminergic (DAergic) neurons may be either genetic or due to exposure to environmental toxins that mark the onset of Parkinson’s disease (PD) pathology. Treatments like surgery and symptoms relieving drugs are available, but they have their side effects during prolonged consumption. Recent studies have shown that the use of food-derived compounds offers significant prevention and treatment of many neurological disorders. These compounds, commonly known as nutraceuticals, show immense importance in mitigating neuronal disease as there is a strong correlation between food and mental health. Accumulation of α-synuclein protein in the degenerated neurons and concomitant oxidative stressrelated pathological events are critical and known pathological markers of PD therefore, food-derived compounds containing antioxidative capacity may offer therapeutic implications. In addition, nutraceuticals are comparatively cost-effective and the safest alternatives of drugs available. Indian medicine system of Ayurveda has long been incorporating the use of herbs to cure PD. This chapter focuses on the utilization of nutraceuticals and ayurvedic preparations in PD pathology.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 873421719 and j.to_ip >=873421719 )) and ((j.from_date <= 1739834403 and j.to_date >= 1739834403 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 18328) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 873421719 and j.to_ip >=873421719 )) and ((j.from_date <= 1739834403 and j.to_date >= 1739834403 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 18328) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 873421719 and j.to_ip >=873421719 )) and ((j.from_date <= 1739834403 and j.to_date >= 1739834403 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 18328)
      770μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3440 and `b`.`banner_from_date` <= 1739834403 and `b`.`banner_to_date` >= 1739834403 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.03msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3440
      • 3: 1739834403
      • 4: 1739834403
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='b319c68e27c0aac9cea48f0705ec2aca'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        OxwkLJTEclL3eSCqpGo2xpDqxTuTj4kdmLrGCyVQ
        uc_cart_id
        b319c68e27c0aac9cea48f0705ec2aca
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/18328" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/18328
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:20:03GET/chapter/18328112192