NEOPLASIA and FERTILITY

Fertility Sparing Team

Author(s): Enrico Sartori*, Franco E. Odicino, Federico Ferrari and Valentina Zizioli

Pp: 129-147 (19)

DOI: 10.2174/9789815050141122010009

* (Excluding Mailing and Handling)

Abstract

Cancer is a leading cause of death in the female population, accounting for 6.7 million of new diagnoses worldwide. Cancer and its treatment can often impair the chances of having children, and the fertility sparing issueis an emerging need. In fact, more often, women are delaying conception and therefore, an increasing number of women are diagnosed with malignancy before the desired completion of childbearing. The care of these patients is challenging, and complex, and there is a total lack of validated guidelines. The problem of fertility in a cancer patient encounters not only clinical and technical problems, but it raises many other queries about ethical and psychological perspectives. Since an international consensus statement should be produced, the need for a dedicated multidisciplinary approach is mandatory to offer a clinical range of treatment options. Cancer survivors and the medical community have acknowledged the importance of patient counseling and the pursuit of options for fertility preservation. In 2006, the American Society of Clinical Oncology published the first recommendations on fertility preservation; however, despite the increasing awareness regarding these recommendations, fertility preservation services are still underutilized. ASCO guidelines advised oncologists to discuss fertility risks and preservation strategies and make referrals to fertility specialists for interested patients as early as possible. There are some programmatic requirements to set up a fertility preservation service, the most significant of which is the availability of a multidisciplinary medical team. A treatment planning approach in which medical figures are experts in different specialties aims to deliver a global treatment tailored to the patient and its disease. A multidisciplinary approach to debating with fertility-sparing issue in oncological patients has mainly two objectives: firstly, to ensure the oncological safety and, in second place, the verification of the fertility preservation desire, that should be not only the intention of the patient but also compliant to “minimum requirements” and therefore a step-wise and careful selection of the women candidate to conservative treatment is necessary. Counseling of patients pursuing fertility preservation should include a discussion of all methods of fertility preservation as well as the alternatives. Because of the sensitive and urgent nature of fertility preservation, a team approach to patient counseling is recommended. Effective provision of fertility preservation options requires an ongoing collaborative relationship among medical and surgical oncologists, reproductive endocrinologists and other medical figures. Oncologists have the initial responsibility to discuss the reproductive risks of intended therapies with the patient and subsequently make referrals to experienced specialists to discuss available reproductive options, which have to be discussed both for surgical decisions and chemotherapy and/or radiotherapy administration. Multidisciplinary teams should include: oncologists, gynecologic oncologists, radiation therapy specialists, reproductive endocrinology and infertility specialists, andrologists, fertilitydedicated biologists, and nurses in the specialties of oncology and infertility, oncopsychologists and social workers. All of these are required to work together in order to achieve a successful collaborative approach


Keywords: Cancer, Fertility, Multidisciplinary team

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316440840 and j.to_ip >=316440840 )) and ((j.from_date <= 1739834821 and j.to_date >= 1739834821 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17875) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316440840 and j.to_ip >=316440840 )) and ((j.from_date <= 1739834821 and j.to_date >= 1739834821 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17875) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316440840 and j.to_ip >=316440840 )) and ((j.from_date <= 1739834821 and j.to_date >= 1739834821 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17875)
      690μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3410 and `b`.`banner_from_date` <= 1739834821 and `b`.`banner_to_date` >= 1739834821 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.09msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3410
      • 3: 1739834821
      • 4: 1739834821
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='5046ad33b45b5acf8cde8e0a6e403ad9'
      270μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    3Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        gg6oYyyBHVgRP89s65Akq4VNaZzel7wH9ANOI7uu
        uc_cart_id
        5046ad33b45b5acf8cde8e0a6e403ad9
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/17875" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/17875
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjV0bHN2dEtkTHM1ZVpWQm55Rko3TVE9PSIsInZhbHVlIjoiR2JqRjdwMWZ1ZjNYV0JMbzU4Qmk1SzRhcUEyRTN4MlZ6SG9tUGc0RUlTST0iLCJtYWMiOiIwYjJiMTc1NmFkN2UyZTM5ZDZlMmYwOGM4NmRmZDI2ODkwZGNlMzU1MWI2YTRmZjU5MzE2NGQyYjJlZDMwMDg3IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjV0bHN2dEtkTHM1ZVpWQm55Rko3TVE9PSIsInZhbHVlIjoiR2JqRjdwMWZ1ZjNYV0JMbzU4Qmk1SzRhcUEyRTN4MlZ6SG9tUGc0RUlTST0iLCJtYWMiOiIwYjJiMTc1NmFkN2Uy" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:27:01 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik5ua1QzS0VUdlBLV0VwR2s2VVpRSkE9PSIsInZhbHVlIjoiSUxSbm5WUkhqZXdrZmdhcmYrMVdHUkM5S1o1L25jdnNrN0tmZjJwdHFhaXBaMlg2RHJKL1ZFaHFYM3NXUWtpbC9wK000QWVrVmFscG5ZdXgzdGVMcDJod2JSa1h5VllKZkxybHBUMmpqTXlJbHJndGd2enUxc05zcVljMHFGNVMiLCJtYWMiOiI2Y2JlZDc3MDE4NjNjMTYzNzMwODU4NDBkNDlkM2YxZjcwNzYyOWMyYTEzMTQ1NDFmN2JkMzE5YWNmOTkwMjZmIiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:27:01 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ik5ua1QzS0VUdlBLV0VwR2s2VVpRSkE9PSIsInZhbHVlIjoiSUxSbm5WUkhqZXdrZmdhcmYrMVdHUkM5S1o1L25jdnNrN0tmZjJwdHFhaXBaMlg2RHJKL1ZFaHFYM3NXUWtpbC9wK000Q" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkJVWGRuNTFtM0tLN3dGeFZpY2hiZUE9PSIsInZhbHVlIjoiR1VLSXBpTDZQejdpRlBuZ0NvSnFBYm55S01adHlrblNJWnNRTjF5K1ZUSmV3NWhRZlkvcWZZUkcvWTlHOFBjU0t0VTVGSUFDNUNsaFNFM1JFbVZvTk9YSFBNMGVUTmZoMlU5UzRuQ1JEVG1wS1RCL1paS1J6VEhvcjV6Wm85VEwiLCJtYWMiOiIxZjJmMThmOTgwMzhkNDY0MGQ0ODE5YmY2OWRmZjIzYWIzNjQ0NDQwOGMzMGUzM2M2ZGY2NzlkMzExZTYzZWZmIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IkJVWGRuNTFtM0tLN3dGeFZpY2hiZUE9PSIsInZhbHVlIjoiR1VLSXBpTDZQejdpRlBuZ0NvSnFBYm55S01adHlrblNJWnNRTjF5K1ZUSmV3NWhRZlkvcWZZUkc" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik5ua1QzS0VUdlBLV0VwR2s2VVpRSkE9PSIsInZhbHVlIjoiSUxSbm5WUkhqZXdrZmdhcmYrMVdHUkM5S1o1L25jdnNrN0tmZjJwdHFhaXBaMlg2RHJKL1ZFaHFYM3NXUWtpbC9wK000QWVrVmFscG5ZdXgzdGVMcDJod2JSa1h5VllKZkxybHBUMmpqTXlJbHJndGd2enUxc05zcVljMHFGNVMiLCJtYWMiOiI2Y2JlZDc3MDE4NjNjMTYzNzMwODU4NDBkNDlkM2YxZjcwNzYyOWMyYTEzMTQ1NDFmN2JkMzE5YWNmOTkwMjZmIiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:27:01 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ik5ua1QzS0VUdlBLV0VwR2s2VVpRSkE9PSIsInZhbHVlIjoiSUxSbm5WUkhqZXdrZmdhcmYrMVdHUkM5S1o1L25jdnNrN0tmZjJwdHFhaXBaMlg2RHJKL1ZFaHFYM3NXUWtpbC9wK000Q" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkJVWGRuNTFtM0tLN3dGeFZpY2hiZUE9PSIsInZhbHVlIjoiR1VLSXBpTDZQejdpRlBuZ0NvSnFBYm55S01adHlrblNJWnNRTjF5K1ZUSmV3NWhRZlkvcWZZUkcvWTlHOFBjU0t0VTVGSUFDNUNsaFNFM1JFbVZvTk9YSFBNMGVUTmZoMlU5UzRuQ1JEVG1wS1RCL1paS1J6VEhvcjV6Wm85VEwiLCJtYWMiOiIxZjJmMThmOTgwMzhkNDY0MGQ0ODE5YmY2OWRmZjIzYWIzNjQ0NDQwOGMzMGUzM2M2ZGY2NzlkMzExZTYzZWZmIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IkJVWGRuNTFtM0tLN3dGeFZpY2hiZUE9PSIsInZhbHVlIjoiR1VLSXBpTDZQejdpRlBuZ0NvSnFBYm55S01adHlrblNJWnNRTjF5K1ZUSmV3NWhRZlkvcWZZUkc" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "gg6oYyyBHVgRP89s65Akq4VNaZzel7wH9ANOI7uu" "uc_cart_id" => "5046ad33b45b5acf8cde8e0a6e403ad9" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/17875" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:27:01GET/chapter/17875112195