An Update on SARS-CoV-2: Damage-response Framework, Potential Therapeutic Avenues and the Impact of Nanotechnology on COVID-19 Therapy

Nanotechnology Impact and It’s Future Perspectives on COVID-19 Therapy

Author(s): Anitha Sriram, Rahul Kumar, Indrani Maji, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava and Pankaj Kumar Singh * .

Pp: 192-203 (12)

DOI: 10.2174/9789815039863122010012

* (Excluding Mailing and Handling)

Abstract

Nanoscience deals with the study of materials at nanoscale dimensions. It has been shown that modernizing drugs to a nanosized delivery system will afford fruitful outcomes with enhanced efficacy against the virus, reduction of the drug dose and improved targetability with enhanced/sustained bioavailability, If the drug dose is reduced, the dose-related side effects are reduced. Dose reduction through nanotechnology also limits non-target tissue toxicity. Hence, nanotechnology has remarkable potential in the pharmaceutical industry. Due to their small molecular level of tunable size, nanopharmaceuticals (in the form of nanoparticles) will easily enter the cells or tissues. The case of COVID-19, they interact with the virus and act accordingly and might inhibit the viral processes of 2019nCoV in COVID-19. 


Keywords: Active targeting, COVID-19, Gold NPs, Macrophage-targeting, Nanohybrids, Nanoparticles, Nanotechnology, Nb11-59, PLGA NPs.

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