Experimental Stroke

Role of Matrix Metalloproteinases After Stroke: From Basic Research to Clinical Impact

Author(s): Anna Rosell, Eng H. Lo and Xiaoying Wang

Pp: 38-45 (8)

DOI: 10.2174/978160805001710901010038

* (Excluding Mailing and Handling)

Abstract

Matrix metalloproteinases (MMPs) comprise a family of zinc endopeptidases that play major roles in the physiology and pathology of the mammalian central nervous system (CNS). These proteinases are evolutionarily conserved as modulators of extracellular matrix during CNS development. After acute tissue injury such as that which occurs after stroke, MMPs become dysregulated and subsequently mediate acute neurovascular disruption and parenchymal destruction. Animal studies have demonstrated their participation in breakdown of neurovascular matrix and blood-brain barrier disruption with edema and/or hemorrhage. Moreover, perturbation of extracellular homeostasis triggered by MMPs may underlie processes responsible for the hemorrhagic complications of thrombolytic stroke therapy. Conversely, biphasic roles for some MMPs have been established since emerging data also suggest that some aspects of MMP activity during the delayed neuroinflammatory response may contribute to remodeling and stroke recovery.

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      • 11. app/Models/ContentAccess.php:647
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51368230 and j.to_ip >=51368230 )) and ((j.from_date <= 1739834825 and j.to_date >= 1739834825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1733) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51368230 and j.to_ip >=51368230 )) and ((j.from_date <= 1739834825 and j.to_date >= 1739834825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1733) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51368230 and j.to_ip >=51368230 )) and ((j.from_date <= 1739834825 and j.to_date >= 1739834825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1733)
      560μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 916 and `b`.`banner_from_date` <= 1739834825 and `b`.`banner_to_date` >= 1739834825 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.16msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 916
      • 3: 1739834825
      • 4: 1739834825
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4b3f29517d1ccd6a043553ceeb52fa18'
      270μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        JQaY0wj7fU4VHikMXfOOuSE6EkUtUYWHWyOAUngn
        uc_cart_id
        4b3f29517d1ccd6a043553ceeb52fa18
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/12005" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/1733
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImM1Z3JoZTg4OEVzOXZXMytyZ0h5RGc9PSIsInZhbHVlIjoiQU5aZE9BcUVsaFhXVlZxNHZmWk8vOFpmWk12TmtyNGQ4aGQxNHJ2V2FOd3N1WXhTN0lMUk9hWm1IdXpVNE5ZRyIsIm1hYyI6IjdiMzg4NjlmZGFmNWVhMjU5Yjk4YWM3ZTJhZWJhYjA4YWNhMmMxNzI2YjIwMDI2MmYyZjE2ZjNmMWUzOTQxY2IiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6ImNNanBoNUFvTUJQTWs4MXBXMDJrdnc9PSIsInZhbHVlIjoiRDE2N3lJcWtpU1VlL2tWSHJ3TCtBb09UNTY2RDRTUDFOTHY3TGVFc2xFU3dSdVNxRlZWQzhlMEhnZy9WNVVjem1TTDFob3A2S21Zc0lwNktoN2RMRXhndEpuays1VlErS2NNZzBBcUNHZzBPVHhQUEZKWEV2UmZPeklMQkE0cGciLCJtYWMiOiJlMzFlOWFjN2I3MDFlYjAzNzllZTI1ODNjNGU2MThlMzMwYWY2MzI2ZTAyNzk2MTczMzkwMDk0NWJlYWJjNjlhIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6Ii9RZHdKT0MwMytOZ3J2ejltRE92Snc9PSIsInZhbHVlIjoicVlaRU5aRWQ1S0c2Qk8zZisyTWtSTGtUOU93M2gzTFI1YnpZZzZnTzdLNUJnVVIrNkpxOHdVcEV5eDhpemRHU2dSZzV6T0RRMHRpMjZ4SXFldTA1N0Q1Mk5UVUlZUEorUUF6MWJXTXBtWDlOTlVxQ2VjdEplZlNtZ09uc3Fta0ciLCJtYWMiOiI4MGVhOTI0NDE3ZjhiNzYzNzlkMTIxN2IzNzUzZDFlMGZlZGM1MWI2NTBkMzZlM2Y5ZWFlZTAzMzVlYjYzMDMyIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImM1Z3JoZTg4OEVzOXZXMytyZ0h5RGc9PSIsInZhbHVlIjoiQU5aZE9BcUVsaFhXVlZxNHZmWk8vOFpmWk12TmtyNGQ4aGQxNHJ2V2FOd3N1WXhTN0lMUk9hWm1IdXpVNE5ZRyIs" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "JQaY0wj7fU4VHikMXfOOuSE6EkUtUYWHWyOAUngn" "uc_cart_id" => "4b3f29517d1ccd6a043553ceeb52fa18" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/12005" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:27:05GET/chapter/1733112193