Breast Cancer: Current Trends in Molecular Research

Emerging Trends in Bioinformatics for Breast Cancer Molecular Research

Author(s): Sammed N. Mandape * .

Pp: 86-108 (23)

DOI: 10.2174/9781681089522112010007

* (Excluding Mailing and Handling)

Abstract

Applications of bioinformatic methods and high-throughput sequencing techniques have increased exponentially over the last decade, transforming the way we understand complex malignancies such as breast cancer. In this chapter, an overview of recent advances in molecular research in breast cancer using emerging bioinformatics methods is presented. Learnings from scientific studies that have successfully integrated and interpreted massive amounts of data generated from various platforms (multi-omics data) using bioinformatics approaches are also outlined. Additionally, pan-cancer studies that help identify the differences and commonalities across multiple cancers are reviewed. We also discuss bioinformatics applications that transform the way we decipher the OncoGenomic landscape of breast cancer. Finally, this study also summarizes current publicly available bioinformatics tools and databases for breast cancer research. 


Keywords: Bioinformatics, Genomics, High-throughput sequencing, Multiomics, Next-generation sequencing, Pan-cancer analysis, Transcriptomics.

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      • 11. app/Models/ContentAccess.php:647
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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51803705 and j.to_ip >=51803705 )) and ((j.from_date <= 1739834411 and j.to_date >= 1739834411 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17272) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51803705 and j.to_ip >=51803705 )) and ((j.from_date <= 1739834411 and j.to_date >= 1739834411 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17272) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51803705 and j.to_ip >=51803705 )) and ((j.from_date <= 1739834411 and j.to_date >= 1739834411 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17272)
      590μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3367 and `b`.`banner_from_date` <= 1739834411 and `b`.`banner_to_date` >= 1739834411 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.09msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3367
      • 3: 1739834411
      • 4: 1739834411
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4ad926290d6c2a7d235ec401a5ba62b3'
      250μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    7Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        JNq7lckrKb60IZ5nwLkziga5di0vtFaDUrTjy7yb
        uc_cart_id
        4ad926290d6c2a7d235ec401a5ba62b3
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/17272" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
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        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:20:11 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjBZZ3lnbjV3QUw0Y2N5SE11ZC94d3c9PSIsInZhbHVlIjoiYWlBb0VKcEpCUHBMYWlEdzVYMVdZdWdGRTBoOHJ2RHh0Ylo5cEhIaFdjZkVpT2VyMG1QNWx6NGFDeHNOM0NuN01DYTVRa1NJeS9Va2ppT1dWTXh3RU4yNjM0eEpYTHh0N2h2WFNveXhpUmQrYmF4ZWlVc2IrS2Q0WTJWdmJsbDMiLCJtYWMiOiI2MDBlYWMxMTA0MTc0MTVhMGI2NDU5NDE3YTc3MjI0NDU3MGY5ZTg0ODQ2YzkxNmQ3NDU5NGJiMGYwYjllZGU2IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:20:11 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjBZZ3lnbjV3QUw0Y2N5SE11ZC94d3c9PSIsInZhbHVlIjoiYWlBb0VKcEpCUHBMYWlEdzVYMVdZdWdGRTBoOHJ2RHh0Ylo5cEhIaFdjZkVpT2VyMG1QNWx6NGFDeHNOM0NuN01DYTVRa" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlVTRi90bk8wK2hRMkE3enBUKzVWWmc9PSIsInZhbHVlIjoiSDNaQlZYNWNoQkxVTUxCMVlqR3hQNGdNSjNSZkZkT1VNVmRNVkJtY0RSZDZRUmw1dG95RnVScmU3enFqVWp1WTl4RFMrclBmV2UzcFAvY3dzS0ZvczI0WFpzekUxNHptcG43amxDdmM1ODc5dEZDcWJIL0NZWko4eTh5ampZc2kiLCJtYWMiOiJlYzA1Njk2MWM3OWViMDM5N2MzYzQzNDY2NGY2ZDZlNzM2MWZlZGY3OTllZjljNzIzZWMxOTI1OTlkZjY5YjI3IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IlVTRi90bk8wK2hRMkE3enBUKzVWWmc9PSIsInZhbHVlIjoiSDNaQlZYNWNoQkxVTUxCMVlqR3hQNGdNSjNSZkZkT1VNVmRNVkJtY0RSZDZRUmw1dG95RnVScmU" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjBZZ3lnbjV3QUw0Y2N5SE11ZC94d3c9PSIsInZhbHVlIjoiYWlBb0VKcEpCUHBMYWlEdzVYMVdZdWdGRTBoOHJ2RHh0Ylo5cEhIaFdjZkVpT2VyMG1QNWx6NGFDeHNOM0NuN01DYTVRa1NJeS9Va2ppT1dWTXh3RU4yNjM0eEpYTHh0N2h2WFNveXhpUmQrYmF4ZWlVc2IrS2Q0WTJWdmJsbDMiLCJtYWMiOiI2MDBlYWMxMTA0MTc0MTVhMGI2NDU5NDE3YTc3MjI0NDU3MGY5ZTg0ODQ2YzkxNmQ3NDU5NGJiMGYwYjllZGU2IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:20:11 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjBZZ3lnbjV3QUw0Y2N5SE11ZC94d3c9PSIsInZhbHVlIjoiYWlBb0VKcEpCUHBMYWlEdzVYMVdZdWdGRTBoOHJ2RHh0Ylo5cEhIaFdjZkVpT2VyMG1QNWx6NGFDeHNOM0NuN01DYTVRa" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlVTRi90bk8wK2hRMkE3enBUKzVWWmc9PSIsInZhbHVlIjoiSDNaQlZYNWNoQkxVTUxCMVlqR3hQNGdNSjNSZkZkT1VNVmRNVkJtY0RSZDZRUmw1dG95RnVScmU3enFqVWp1WTl4RFMrclBmV2UzcFAvY3dzS0ZvczI0WFpzekUxNHptcG43amxDdmM1ODc5dEZDcWJIL0NZWko4eTh5ampZc2kiLCJtYWMiOiJlYzA1Njk2MWM3OWViMDM5N2MzYzQzNDY2NGY2ZDZlNzM2MWZlZGY3OTllZjljNzIzZWMxOTI1OTlkZjY5YjI3IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IlVTRi90bk8wK2hRMkE3enBUKzVWWmc9PSIsInZhbHVlIjoiSDNaQlZYNWNoQkxVTUxCMVlqR3hQNGdNSjNSZkZkT1VNVmRNVkJtY0RSZDZRUmw1dG95RnVScmU" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "JNq7lckrKb60IZ5nwLkziga5di0vtFaDUrTjy7yb" "uc_cart_id" => "4ad926290d6c2a7d235ec401a5ba62b3" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/17272" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:20:11GET/chapter/17272112199