Abstract
Colorectal cancer (CRC) is a disease that is initiated by the interrelation of
genetic and environmental factors. Colorectal cancer progresses through the
accumulation of genetic and epigenetic changes. This review discusses, in detail, the
role of lncRNAs in colorectal cancer, focusing on various signaling pathways involved
in colorectal cancer pathogenesis, viz., Wnt/-catenin signaling pathway, epidermal
growth factor receptor (EGFR)/insulin-like growth factor type I receptor (IGF-IR)
signaling pathway (KRAS and phosphatidylinositol-3-kinase (PI3K) pathways),
transforming growth factor-beta (TGF-) signaling pathway, p53 signaling pathway, and
the epithelial-mesenchymal transition (EMT) program.
Keywords: Apoptosis, Colorectal cancer, LncRNAs, Signalling pathway.