Pediatric Anesthesia: A Guide for the Non-Pediatric Anesthesia Provider Part II

Research in Pediatric Anesthesia

Author(s): Noud van Helmond and Bharathi Gourkanti * .

Pp: 195-204 (10)

DOI: 10.2174/9789815036213122010010

* (Excluding Mailing and Handling)

Abstract

In the United States and globally, governmental organizations have initiated programs to stimulate clinical research in the pediatric population. The most important reason for these programs is a lack of high-quality evidence to guide effective and safe treatment in children. In pediatric anesthesiology, physicians and scientists need to evaluate anesthetic drugs, medical equipment, and devices. Under improved global regulations, current and new anesthetic strategies will undergo a scientific evaluation of safety and effectiveness. Along these lines, the number of pediatric patients participating in anesthesiology research is expected to increase. Federal regulations deem minors to lack the required decision-making capacity to consent to participate in studies. In line with the Declaration of Helsinki, enrolling children in research should encompass legal guardian permission and assent of the child. Proxy consent and assent procedures should enable the legal representative to safeguard the child's interest while allowing the child to give meaningful agreement. Assent has been defined in detail by ethical scholars but is generally poorly defined legally. A specific challenge to appropriate proxy consent and a child's assent in pediatric anesthesiology research is the brief treatment interaction the pediatric anesthesiologist can have with patients. This challenge may require contacting potential research subjects well before admission to the hospital, depending on the risk and complexity associated with the study at hand. 


Keywords: Assent, Consent, Ethical review, Institutional review board, Pediatric anesthesia, Quality improvement, Research, Risk.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309824417 and j.to_ip >=309824417 )) and ((j.from_date <= 1739835101 and j.to_date >= 1739835101 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17050) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309824417 and j.to_ip >=309824417 )) and ((j.from_date <= 1739835101 and j.to_date >= 1739835101 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17050) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309824417 and j.to_ip >=309824417 )) and ((j.from_date <= 1739835101 and j.to_date >= 1739835101 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17050)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3351 and `b`.`banner_from_date` <= 1739835101 and `b`.`banner_to_date` >= 1739835101 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.08msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3351
      • 3: 1739835101
      • 4: 1739835101
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='c5ddaad88f51b123a9e09bc9dfc5bd43'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    8Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        KalDVPyxMbai4iZcXh6Q9r66lJqMp7Ha3XbpW9y3
        uc_cart_id
        c5ddaad88f51b123a9e09bc9dfc5bd43
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/17050" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/17050
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:31:41GET/chapter/170501121910