Chemical-Induced Seizures: Mechanisms, Consequences and Treatment

Seizures and Other Neurological Symptoms Induced by Organophosphates,Including Warfare Nerve Agents

Author(s): Adam-Scott Feiner, Bertrand Yersin, Andreas Stettbacher, Sergei Bankoul, Christophe Baumberger, Pierre-Nicolas Carron

Pp: 29-38 (10)

DOI: 10.2174/978160805274511101010029

* (Excluding Mailing and Handling)

Abstract

Acute organophosphate (OP) intoxication is associated with many symptoms and clinical signs, including potentially life-threatening seizures and status epilepticus. Instead of being linked to the direct cholinergic toxidrome, OP-related seizures are more probably linked to the interaction of OPs with acetylcholineindependent neuromodulation pathways, such as GABA and NMDA. The importance of preventing, or recognizing and treating OP-related seizures lies in that, the central nervous system (CNS) damage from OP poisoning is thought to be due to the excitotoxicity of the seizure activity itself rather than a direct toxic effect. Muscular weakness and paralysis occurring 1-4 days after the resolution of an acute cholinergic toxidrome, the intermediate syndrome is usually not diagnosed until significant respiratory insufficiency has occurred; it is nevertheless a major cause of OP-induced morbidity and mortality and requires aggressive supportive treatment. The condition usually resolves spontaneously in 1-2 weeks.

Treatment of OP intoxication relies on prompt diagnosis, and specific and immediate treatment of the lifethreatening symptoms. Since patients suffering from OP poisoning can secondarily expose care providers via contaminated skin, clothing, hair, or body fluids. EMS and hospital caregivers should be prepared to protect themselves with appropriate protective equipment, isolate such patients, and decontaminate them. After prompt decontamination, the initial priority of patient management is an immediate ABCDE (A : airway, B : breathing, C : circulation, D : dysfunction or disability of the central nervous system, and E : exposure) resuscitation approach, including aggressive respiratory support, since respiratory failure is the usual ultimate cause of death. The subsequent priority is initiating atropine therapy to oppose the muscarinic symptoms and diazepam to prevent or control seizures, with oximes added to enhance acetylcholinesterase (AChE) activity recovery. Large doses of atropine and oximes may be necessary for poisoning due to suicidal ingestions of OP pesticides.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version172msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[23:29:47] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (96.68ms)time
  • Application (75.67ms)time
  • 1 x Booting (56.09%)
    96.68ms
    1 x Application (43.9%)
    75.67ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed22.46ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59235952','',1,1739834987,1739834987) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739834987
      1.06msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59235952','/chapter/1690',1,1739834987,1739834987)
      230μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59235952 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59235952) limit 1
      12.78msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59235952
      • 1: 59235952
      • 2: 59235952
      • 3: 59235952
      • 4: 59235952
      • 5: 59235952
      • 6: 59235952
      • 7: 59235952
      • 8: 59235952
      • 9: 59235952
      • 10: 59235952
      • 11: 59235952
      • 12: 59235952
      • 13: 59235952
      • 14: 59235952
      • 15: 59235952
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '1690' limit 1
      230μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 1690
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '1690' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      500μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 1690
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '1690'
      180μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 1690
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 125 limit 1
      190μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 125
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=125) and se.ebook_id!=125 and v.ebook_status='1'
      2.46msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=125) and se.ebook_id!=125 and v.ebook_status='1' limit 10 offset 0
      660μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=125)
      370μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=125) limit 10 offset 0
      400μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 912 and `e`.`is_uploaded` = 1
      420μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 912
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 125 and ebook_volume_id <> 912 limit 1
      220μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 125
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1690' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '912' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      230μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59235952 and j.to_ip >=59235952 )) and ((j.from_date <= 1739834987 and j.to_date >= 1739834987 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 912) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59235952 and j.to_ip >=59235952 )) and ((j.from_date <= 1739834987 and j.to_date >= 1739834987 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 912) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59235952 and j.to_ip >=59235952 )) and ((j.from_date <= 1739834987 and j.to_date >= 1739834987 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 912)
      540μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59235952 and j.to_ip >=59235952 )) and ((j.from_date <= 1739834987 and j.to_date >= 1739834987 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1690) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59235952 and j.to_ip >=59235952 )) and ((j.from_date <= 1739834987 and j.to_date >= 1739834987 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1690) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59235952 and j.to_ip >=59235952 )) and ((j.from_date <= 1739834987 and j.to_date >= 1739834987 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1690)
      490μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 912 and `b`.`banner_from_date` <= 1739834987 and `b`.`banner_to_date` >= 1739834987 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.03msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 912
      • 3: 1739834987
      • 4: 1739834987
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='86439966145800067f47eb222247ac22'
      190μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        2jSSSkIvPoY7JqBhNocfHxFftf3dMhKs8LwZo6oW
        uc_cart_id
        86439966145800067f47eb222247ac22
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1690" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/1690
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IkVlZklma1VRKzFoNk5ZdW1MV0k0YkE9PSIsInZhbHVlIjoiazZtaUl3RFVXMDZnblMyOGhNbm1zd3JkbzZDOC9OeUtMeTZCbUFMUStLcXA4cTlnYXlWY1UrS0pUbm9kQnp2NyIsIm1hYyI6IjYxMTAyODkwODMxZDJhMjgwZWYxNWMyZDdiMDM2NjYwOTljMjUxOTNmNzFmMmRmZjgyY2Y2ZTZkNDVkMzc0OTAiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6Im81S1ZwTjBBMnprRnltZFVqVmhJcHc9PSIsInZhbHVlIjoiWjQ2TVZKcy95L0wwblVCUk5mZ1BEVm43NkwvVjJoSmFtNGlHamVRVzd4bWNWeDdzV0VIL01GRzZlSExaNHFFcmx3U3ZxWUdYWWloR25ubDMrbmE0Wjdvckw3aFlJTi9jc2E0RTE2N3ZDdW5xaUlaSlFLSlZ2dnAwTnhDemtrYkwiLCJtYWMiOiJiMzg1N2RkNWRhM2M4NGFiZjAyODMyOTFhYzRlODFjOTlmYmJkYmJkNDU3MTEzNzllZDNkNTQ1NWMyYTI1OWE4IiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6Imd6OEZFeVVQRTUrK0g3ZmtBdTB5U1E9PSIsInZhbHVlIjoiVFlaMkszS1RyRmFlV25RcmpZTGJkdUNxUkpNZk1CRTVyZ0tReU9IS1FoK2FlMzh5U2hlWlc3WDFDR2h5QUFMRm1QTWE2aXdxWWNtWVV1SGdxVXhtbmZQRDdMZFUrSjFzYkJ3aGNvRm1rUTJsb3lBV0FRcm5nWi93eTVvd2dkaGMiLCJtYWMiOiI3OWE4ZGM5NzI2OGYxMDA1OWIzNDZkMDU5ZTgwMTcxMDcxZGE2MmEzZDQzYWFmODk5NWUwYzYyMDgxYjIxYzVlIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IkVlZklma1VRKzFoNk5ZdW1MV0k0YkE9PSIsInZhbHVlIjoiazZtaUl3RFVXMDZnblMyOGhNbm1zd3JkbzZDOC9OeUtMeTZCbUFMUStLcXA4cTlnYXlWY1UrS0pUbm9kQnp2NyIs" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:3 [ "wayfindertarget" => null "XSRF-TOKEN" => "2jSSSkIvPoY7JqBhNocfHxFftf3dMhKs8LwZo6oW" "alphaeurekaselectnet_session" => "hroisO2BcHxG6vTj4Dh24TZq5Fd4yEJiEEoR8UgL" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:29:47 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImlPUFhhMDZ3aVd6MzEyTEFtWnBkT1E9PSIsInZhbHVlIjoiL3R4RFdSQVN2SjI0ZlJKYU00dWtyaENPaDI0MDdxNitvZjJuREp5bnZhUVNkVGNQUnNGaHIzZWNGVThnVHE5MTZ5RlFDeVoxSDdDYTZ4Z1cxdVJLeWthTG5YdXVzcno1em95SjNEWU5iVHJQSk5EbmsySjZIaTV0UjZOWGZES2MiLCJtYWMiOiIzMGJhOTZkMjk5ZThjYWQyZmQwZDEzNDlmNDBmODA0ZDRiNzQ0MmI0ODMzM2YwMWY1OTg2NGU3YmUwNzQ2YmY4IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:29:47 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImlPUFhhMDZ3aVd6MzEyTEFtWnBkT1E9PSIsInZhbHVlIjoiL3R4RFdSQVN2SjI0ZlJKYU00dWtyaENPaDI0MDdxNitvZjJuREp5bnZhUVNkVGNQUnNGaHIzZWNGVThnVHE5MTZ5RlFDe" 1 => "alphaeurekaselectnet_session=eyJpdiI6InJuaUJJRnJwWVNFcWdlM1B3ZDVOT1E9PSIsInZhbHVlIjoiYkRjYW9heDVpMi81czBTem1JUTBtRlMvdi9RWTZhV2RDQ3JIOEdLcFRCZUM1MWlmSzZ3ZDY5OWZqUHUxOElvMThSNVJQVEVibHJCbEpPWVE1bW5TbDhnUGwwQ1ZHeVVKcDd6M3ZoM0JnWlVEQ1R1eHBIYWYyMGZpbTZEMHJONFMiLCJtYWMiOiIzNzE3NjhiZTcwOTMxNmQ2ODQzOWQwOTQ4YTI3MmU4NWJiNDY0ZDhjMGEyN2FhN2UzMGYzMmI2ZDdkYjhlMTI2IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InJuaUJJRnJwWVNFcWdlM1B3ZDVOT1E9PSIsInZhbHVlIjoiYkRjYW9heDVpMi81czBTem1JUTBtRlMvdi9RWTZhV2RDQ3JIOEdLcFRCZUM1MWlmSzZ3ZDY5OWZ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImlPUFhhMDZ3aVd6MzEyTEFtWnBkT1E9PSIsInZhbHVlIjoiL3R4RFdSQVN2SjI0ZlJKYU00dWtyaENPaDI0MDdxNitvZjJuREp5bnZhUVNkVGNQUnNGaHIzZWNGVThnVHE5MTZ5RlFDeVoxSDdDYTZ4Z1cxdVJLeWthTG5YdXVzcno1em95SjNEWU5iVHJQSk5EbmsySjZIaTV0UjZOWGZES2MiLCJtYWMiOiIzMGJhOTZkMjk5ZThjYWQyZmQwZDEzNDlmNDBmODA0ZDRiNzQ0MmI0ODMzM2YwMWY1OTg2NGU3YmUwNzQ2YmY4IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:29:47 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImlPUFhhMDZ3aVd6MzEyTEFtWnBkT1E9PSIsInZhbHVlIjoiL3R4RFdSQVN2SjI0ZlJKYU00dWtyaENPaDI0MDdxNitvZjJuREp5bnZhUVNkVGNQUnNGaHIzZWNGVThnVHE5MTZ5RlFDe" 1 => "alphaeurekaselectnet_session=eyJpdiI6InJuaUJJRnJwWVNFcWdlM1B3ZDVOT1E9PSIsInZhbHVlIjoiYkRjYW9heDVpMi81czBTem1JUTBtRlMvdi9RWTZhV2RDQ3JIOEdLcFRCZUM1MWlmSzZ3ZDY5OWZqUHUxOElvMThSNVJQVEVibHJCbEpPWVE1bW5TbDhnUGwwQ1ZHeVVKcDd6M3ZoM0JnWlVEQ1R1eHBIYWYyMGZpbTZEMHJONFMiLCJtYWMiOiIzNzE3NjhiZTcwOTMxNmQ2ODQzOWQwOTQ4YTI3MmU4NWJiNDY0ZDhjMGEyN2FhN2UzMGYzMmI2ZDdkYjhlMTI2IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InJuaUJJRnJwWVNFcWdlM1B3ZDVOT1E9PSIsInZhbHVlIjoiYkRjYW9heDVpMi81czBTem1JUTBtRlMvdi9RWTZhV2RDQ3JIOEdLcFRCZUM1MWlmSzZ3ZDY5OWZ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "2jSSSkIvPoY7JqBhNocfHxFftf3dMhKs8LwZo6oW" "uc_cart_id" => "86439966145800067f47eb222247ac22" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1690" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:29:47GET/chapter/1690112193