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Nanotherapeutics for the Treatment of Hepatocellular Carcinoma

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Nanoformulations to Limit Challenges of Conventional Therapy Against Hepatocellular Carcinoma – An Overview

Author(s): Suresh Ajmeera and V. Badireenath Konkimalla * .

Pp: 166-218 (53)

DOI: 10.2174/9789815039740122010006

* (Excluding Mailing and Handling)

Abstract

The chapter primarily deals with different nano-drug delivery approaches to
overcome current HCC chemotherapy challenges. The objective of organizing the
various sections in this chapter is to highlight the different nanoformulations that are
currently being explored, benefits of nanoformulations over the free drug, different
approaches and molecular blocks utilized for preparation on different nanoformulations
and their applications in the context of the development of novel drug delivery
approaches in HCC. Conventional chemotherapy and its limitations for HCC, different
targeting approaches for HCC, need for nanoparticulate approach in HCC, different
strategies for delivery of nanoformulations with different targeting approaches,
different nanoformulations (liposomes, micelles, hydrogels, etc.) that are currently
studied in HCC, different molecular blocks under preparation, the current status of
clinical trials of different nanoformulations studied for HCC therapy and perspective
for futuristic role of nanoformulations in HCC have been discussed in the present
chapter.

Keywords: Active targeting, Albumin, Amphiphilic formulations, Biocompatibility, Clinical trials, Combinational nanoformulations, Emulsomes, Hydrogels, Liposomes, Metallic nanoparticles, Micelles, miRNAs, Multidrug therapy, Multikinase inhibitor, Nanoparticles, Passive targeting, Polysaccharides, Site-specific targeting, Sorafenib, Stimuli-responsive nanoparticles, Targeted delivery.

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