Copper: Quest for a Cure

A New Beginning

Author(s): John Walshe

Pp: 14-23 (10)

DOI: 10.2174/978160805060410901010014

* (Excluding Mailing and Handling)

Abstract

Having been appointed Assistant Director of Research to Professor McCance in Cambridge I needed to find somewhere to live and to decide upon a line of research in keeping with the facilities available.. Shortly after taking up this new post I was invited, by the British Council, to undertake a lecture tour in South America. On returning from this I succeeded in establishing the methods I needed to estimate abnormalities of copper metabolism and to recruit patients for my studies. I also continued my work with Sydney Osborn, a medical physicist, and we improved our methods of determining the movement of copper in the body using a short half life radioactive isotope of copper.

Whilst the results of treatment with penicillamine were very encouraging I encountered the problem of a patient developing a severe toxic reaction to the drug. A University biochemist, Dr Hal Dixon, suggested I use triethylenetetramine, a known copper binding compound and this proved safe and effective. For several years we produced this in my laboratory to treat a small number of penicillamine intolerant patients. We also found that an impurity in this compound could induced a disastrous fall in blood pressure. During the course of these studies we moved premises twice, first temporary war time huts in Canhams yard and then the old Low Temperature Research building in the Downing Street site. During this time I also had trouble with the Ministry of Health over the question of prescription charges for my patients.

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version204msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[23:20:32] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (114ms)time
  • Application (89.69ms)time
  • 1 x Booting (55.94%)
    114ms
    1 x Application (44.06%)
    89.69ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed32.12ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51592399','',1,1739834432,1739834432) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739834432
      1.02msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51592399','/chapter/1650',1,1739834432,1739834432)
      170μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51592399 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51592399) limit 1
      20.23msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51592399
      • 1: 51592399
      • 2: 51592399
      • 3: 51592399
      • 4: 51592399
      • 5: 51592399
      • 6: 51592399
      • 7: 51592399
      • 8: 51592399
      • 9: 51592399
      • 10: 51592399
      • 11: 51592399
      • 12: 51592399
      • 13: 51592399
      • 14: 51592399
      • 15: 51592399
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '1650' limit 1
      310μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 1650
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '1650' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      680μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 1650
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '1650'
      220μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 1650
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 123 limit 1
      250μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 123
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=123) and se.ebook_id!=123 and v.ebook_status='1'
      3.59msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=123) and se.ebook_id!=123 and v.ebook_status='1' limit 10 offset 0
      920μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=123)
      600μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=123) limit 10 offset 0
      470μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 909 and `e`.`is_uploaded` = 1
      460μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 909
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 123 and ebook_volume_id <> 909 limit 1
      260μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 123
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '1650' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      270μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '909' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      270μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51592399 and j.to_ip >=51592399 )) and ((j.from_date <= 1739834432 and j.to_date >= 1739834432 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 909) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51592399 and j.to_ip >=51592399 )) and ((j.from_date <= 1739834432 and j.to_date >= 1739834432 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 909) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51592399 and j.to_ip >=51592399 )) and ((j.from_date <= 1739834432 and j.to_date >= 1739834432 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 909)
      570μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51592399 and j.to_ip >=51592399 )) and ((j.from_date <= 1739834432 and j.to_date >= 1739834432 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1650) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51592399 and j.to_ip >=51592399 )) and ((j.from_date <= 1739834432 and j.to_date >= 1739834432 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1650) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51592399 and j.to_ip >=51592399 )) and ((j.from_date <= 1739834432 and j.to_date >= 1739834432 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1650)
      560μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 909 and `b`.`banner_from_date` <= 1739834432 and `b`.`banner_to_date` >= 1739834432 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.05msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 909
      • 3: 1739834432
      • 4: 1739834432
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='39185d93843a02e7e0406ebf4c0601a2'
      220μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        FLb8L368PyMsGmHi965K8S6dEQKbbCQjhHSvx18Z
        uc_cart_id
        39185d93843a02e7e0406ebf4c0601a2
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1650" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/1650
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImlrVERza0tZbitqT1FHOVJReC81cEE9PSIsInZhbHVlIjoiWjFaanNudlp2bnhFanJnc2ZuT0d4Y05mYThra3JqL2FYZjUzZFB2L2NEM0ZMejVIUCtiaEw1ZjdVdElIM2FHa0grR29xUkxCNk1DQklBNFpPOVhlcUE9PSIsIm1hYyI6IjIxZmM0ZTY2MGM1YzJhODg4ZmEyN2IxZWE1OThjMGFmNTIzMjBkMGE2NDczYWE2ZDBkYjgyNjJjZDdhMDgxM2UiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6IjJzM2hyUWEvTEhER0NBMi9MNk1DcEE9PSIsInZhbHVlIjoiT0s1QkJVZWh4bExVcnhydXd2aEtKMU1OaHRPNDd1T3lSanFaN0duVzlGSytZeWZFSlJvSzlSV0llRUFLQWMxaXNkNlg2R215WC9UMmV3V1l6MDF4Z200YUl2OUk3QzhLN0tBNFJrYmE4RzRTODVjcVpQVEM4OEpVa3dYOG4yZWYiLCJtYWMiOiIyNzMyMDcxMWIyZDJmZGI2MDM1OTAzODM2Zjk1NGU3YTA3YTZlMjJjMWRjYjFjNTIwODkzNDkxZThmOWUzYzJjIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6IktFYlhSYmhYNS9kbWExQk5EUGhTUVE9PSIsInZhbHVlIjoiSDZmdlRBR3BwVUVOOTYza2lPajBoVXRkVlczZ1Q4QTNkRTlmRnN6a2hLNFNtdXlwcFdXMDdZYTY4QUN3UUw2RDByTDBiT2JPQUZyU1lqVkJUN01SZEo4UDhFTktaaHRmR3hxRWs5WXFWSlZ4MXZaRTB0Z0V1a3dFZnkwY1JKbEYiLCJtYWMiOiI1N2NhYjNjOTZmNTQ4YTAxMTA4ZTM1ZmFiYWQ0ZDhmMGM0MDlhZjAzYTBlZGQ1MDBhMzBjNDczNWIwYWZhZTAzIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImlrVERza0tZbitqT1FHOVJReC81cEE9PSIsInZhbHVlIjoiWjFaanNudlp2bnhFanJnc2ZuT0d4Y05mYThra3JqL2FYZjUzZFB2L2NEM0ZMejVIUCtiaEw1ZjdVdElIM2FHa0gr" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:3 [ "wayfindertarget" => null "XSRF-TOKEN" => "FLb8L368PyMsGmHi965K8S6dEQKbbCQjhHSvx18Z" "alphaeurekaselectnet_session" => "g7RqbTzDRWnoTwHYZEq8bGhG6JoXzT6y6gpwvb1C" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:20:32 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InpacHBHNG5yT2drVjJmeTJKei9tTFE9PSIsInZhbHVlIjoiOGJJZElJeGZydlkxcC9URURUNWp4RW52MVF2QTI0cUhlR2pFWnVMR01qUWIyaU03ejN0dzFvTW1MN0w1MXpSMGhKaFl6S0ZpT25tallzL2VSZTFPRmRySzVnbkRjRlhNUGNxRDAxWGNjazhBK3IxZ2UwQWVpaHcxNzF5bk85N3UiLCJtYWMiOiIyMmZiMmZmOGNhYzViZTQ5M2JkYjYwY2NlMjBkMGFkZTg4NDA5MGE1NmIwMTVhYjMyYzUzNzlkNzA4NWFjYWNlIiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:20:32 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InpacHBHNG5yT2drVjJmeTJKei9tTFE9PSIsInZhbHVlIjoiOGJJZElJeGZydlkxcC9URURUNWp4RW52MVF2QTI0cUhlR2pFWnVMR01qUWIyaU03ejN0dzFvTW1MN0w1MXpSMGhKaFl6S" 1 => "alphaeurekaselectnet_session=eyJpdiI6IitOaGp3NllYMlJuN3NVRWR6aisreXc9PSIsInZhbHVlIjoiVlNGUTc2MjZrR0d0VTZ3RHVjQ0tkNWhpOXNDMXptaVpFand4L2pVdzlja2krOHE0Y3VWSTVFaHJSd2YzVlBhbE40eDVjT2JEbkJQVnN4OG9LUFNUOVQzZVBmdW41bG9HWllOT3JjNFp4TzE3d3hvZlpJNEovVzVpTXhqa0pHVG8iLCJtYWMiOiI3OTc2NGQ0Yjc2MDdiYmRlYWRjYjg3NGNlNzRjN2Y0ZjNlZmJkMjQxNWQyZjI3ZTBjZGU4MzMxYTc5MjIzNjhhIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IitOaGp3NllYMlJuN3NVRWR6aisreXc9PSIsInZhbHVlIjoiVlNGUTc2MjZrR0d0VTZ3RHVjQ0tkNWhpOXNDMXptaVpFand4L2pVdzlja2krOHE0Y3VWSTVFaHJ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InpacHBHNG5yT2drVjJmeTJKei9tTFE9PSIsInZhbHVlIjoiOGJJZElJeGZydlkxcC9URURUNWp4RW52MVF2QTI0cUhlR2pFWnVMR01qUWIyaU03ejN0dzFvTW1MN0w1MXpSMGhKaFl6S0ZpT25tallzL2VSZTFPRmRySzVnbkRjRlhNUGNxRDAxWGNjazhBK3IxZ2UwQWVpaHcxNzF5bk85N3UiLCJtYWMiOiIyMmZiMmZmOGNhYzViZTQ5M2JkYjYwY2NlMjBkMGFkZTg4NDA5MGE1NmIwMTVhYjMyYzUzNzlkNzA4NWFjYWNlIiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:20:32 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InpacHBHNG5yT2drVjJmeTJKei9tTFE9PSIsInZhbHVlIjoiOGJJZElJeGZydlkxcC9URURUNWp4RW52MVF2QTI0cUhlR2pFWnVMR01qUWIyaU03ejN0dzFvTW1MN0w1MXpSMGhKaFl6S" 1 => "alphaeurekaselectnet_session=eyJpdiI6IitOaGp3NllYMlJuN3NVRWR6aisreXc9PSIsInZhbHVlIjoiVlNGUTc2MjZrR0d0VTZ3RHVjQ0tkNWhpOXNDMXptaVpFand4L2pVdzlja2krOHE0Y3VWSTVFaHJSd2YzVlBhbE40eDVjT2JEbkJQVnN4OG9LUFNUOVQzZVBmdW41bG9HWllOT3JjNFp4TzE3d3hvZlpJNEovVzVpTXhqa0pHVG8iLCJtYWMiOiI3OTc2NGQ0Yjc2MDdiYmRlYWRjYjg3NGNlNzRjN2Y0ZjNlZmJkMjQxNWQyZjI3ZTBjZGU4MzMxYTc5MjIzNjhhIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IitOaGp3NllYMlJuN3NVRWR6aisreXc9PSIsInZhbHVlIjoiVlNGUTc2MjZrR0d0VTZ3RHVjQ0tkNWhpOXNDMXptaVpFand4L2pVdzlja2krOHE0Y3VWSTVFaHJ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "FLb8L368PyMsGmHi965K8S6dEQKbbCQjhHSvx18Z" "uc_cart_id" => "39185d93843a02e7e0406ebf4c0601a2" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1650" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:20:32GET/chapter/1650112193