Copper: Quest for a Cure

Progress

Author(s): John Walshe

Pp: 9-13 (5)

DOI: 10.2174/978160805060410901010009

* (Excluding Mailing and Handling)

Abstract

On returning to University College Hospital in London I needed to find patients with this rare disease and supplies of penicillamine to assess its ability to mobilise copper from their abnormal body stores. Three patients were found by my father, Sir Francis Walshe, a distinguished neurologist, and with the small amount of penicillamine available to me I was able to show that in each case penicillamine promoted the excretion of more copper than did BAL. Two patients were returned to their referring physicians but the third stayed with me for over 50 years and made an excellent recovery eventually having three children of her own.

Supplies of penicillamine were secured when I was able to convince the medical director of the Distillers Company, the principal makers of penicillin at the time, to make penicillamine for me.

By the early 1960s reports from my own work and from other centres appeared showing that patients treated with penicillin showed a remarkable improvement in all symptoms.

However Propfessor Denny Brown and Dr Uzman in Boston still believed that Wilson's disease was not due to copper deposition but due to abnormal protein metabolism with abnormal peptides being excreted in the urine. Working with Professor Milne and Dr Asatoor at the Hammersmith Hospital, it was possible to disprove this theory using newer techniques to analyse urine.

In 1957, after failing to get appointed to two different appointments in Oxford I was accepted to a post in the Department of Experimental Medicine in Cambridge.

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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834614 and j.to_date >= 1739834614 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1648) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834614 and j.to_date >= 1739834614 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1648) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51399716 and j.to_ip >=51399716 )) and ((j.from_date <= 1739834614 and j.to_date >= 1739834614 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 1648)
      510μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 909 and `b`.`banner_from_date` <= 1739834614 and `b`.`banner_to_date` >= 1739834614 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.03msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 909
      • 3: 1739834614
      • 4: 1739834614
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='cd40582b2150d48a8a658460c1d80c2a'
      200μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Keywords
    1Keywords.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        zsArVsQ96x6peanjLpSpbWfXRbeEg3z1jNafbREp
        uc_cart_id
        cd40582b2150d48a8a658460c1d80c2a
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1648" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/1648
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "zsArVsQ96x6peanjLpSpbWfXRbeEg3z1jNafbREp" "uc_cart_id" => "cd40582b2150d48a8a658460c1d80c2a" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/1648" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:23:34GET/chapter/1648112193