Nanotechnology Driven Herbal Medicine for Burns: From Concept to Application

A Novel Herbal Informatic Approach for the Management of Skin Burn Injury

Author(s): Ankit Tanwar*, Ruby Sharma, Ayesha Ali Zaidi, Deepti Sharma, Rashmi Wardhan, Raman Chawla, Himanshu Ojha, Rajesh Arora and Haider Ali Khan

Pp: 152-174 (23)

DOI: 10.2174/9789815039597121010012

* (Excluding Mailing and Handling)

Abstract

Skin burn injury is a prominent unintended injury that results in lifelong
physical and mental scarring, causing pain and subsequent mortality. Notwithstanding
a considerable decrease in their incidence, burn injuries remain as one of the most
common forms of trauma and also account for affecting the mental health, quality of
life all around the globe. Burn injuries can be managed using chemotherapeutic
modalities and have always been the domain of burn consultants. According to the
WHO (world health organization), approximately 1,80,000 deaths occur every year that
are caused by burns, and the vast majority occur in countries with low and middleincome.
This incidence is higher due to illiteracy, poverty, and lack of safety
awareness. Despite the availability of numerous therapeutic moieties and ointments
available commercially, people are more converging on the herbals remedies due to
their holistic approach and less toxic effects. In this book chapter, we are focusing on
the novel Herbal Informatic model for the identification of ethnopharmacologically
based predominant phytoconstituents or Nano-phytomedicines (NPs) for the
management of skin burn injury. This model was pre-validated by Tanwar et al., on
several disease models such as Autoimmune disorders like Rheumatoid Arthritis (RA),
Gout; Metabolic disorders like Diabetes, and several Nosocomial infections such as
Salmonella, E. coli, Clostridium species, etc. This novel tool involves the rationalebased
selection of herbals that could be an integrated ‘Herbal Informatics’ approach employing the use of both ethnopharmacological/traditional knowledge from the
Ayurvedic Medicinal System (AMS) and in silico bio-informatics search tools. This
combinatorial approach serves to retrieve information about a plant and reveals their
phytoconstituents based on medicinal properties for targeting virulence
factors/biomarkers involved in the progression of burn injury. In this chapter, we are
emphasizing the 5-major steps that are involved in scrutinizing the robust druggable
natural compounds that could be utilized to develop Nano-phytomedicines (NPs) for
the management of skin burn injury or burn sepsis and can also be effective in the drug
discovery process followed by study at in vitro and in vivo level.


Keywords: Ayurvedic Medicinal System, Burn Injury, Ethnopharmacological Knowledge, Ethnopharmacological, Herbal Informatics, Nano-phytomedicines, Skin Injury, WHO.

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      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59134794 and j.to_ip >=59134794 )) and ((j.from_date <= 1739834448 and j.to_date >= 1739834448 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16228) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59134794 and j.to_ip >=59134794 )) and ((j.from_date <= 1739834448 and j.to_date >= 1739834448 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16228) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59134794 and j.to_ip >=59134794 )) and ((j.from_date <= 1739834448 and j.to_date >= 1739834448 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16228)
      560μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3286 and `b`.`banner_from_date` <= 1739834448 and `b`.`banner_to_date` >= 1739834448 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.03msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3286
      • 3: 1739834448
      • 4: 1739834448
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='8b2782f5bed06b572c7aaf42680df52a'
      190μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    8Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        gj0DKypQs0BYbHQ1oqjIuuoEke43LacflyFw3kfl
        uc_cart_id
        8b2782f5bed06b572c7aaf42680df52a
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/16228" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/16228
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjNXWktvcElBVG5GN0pXc21tcUdUd0E9PSIsInZhbHVlIjoiMkl3N1BVT29hVHArNGdtYmpSekJrcFJxTWVaeEgxaXZ3V0lHTnNSeXRyeUcvbGQ0TTZnSDd6aGVtMkJ0NFdicCIsIm1hYyI6ImIyYjRhY2Y4NWIzNTAwYmVmZjhmMzc2M2E5ZmZiZDNmMWQ4ZmNiY2IwMGQzMDViM2M2ZTA1M2I0ZmVlNzdjZDIiLCJ0YWciOiIifQ%3D%3D; XSRF-TOKEN=eyJpdiI6IitpcHhQWmgyRXR3b0pMS0pIeWdIS2c9PSIsInZhbHVlIjoiRGtrNEVNUlRqNUV2MGxtNndSemNwVnZxZkpCb25Oa21RNDI4MlZqdkxVVHFPRE5OZ0dRNi9pcGNHeXZXaG1GZnNRTVRDWEsxNUlhWkhBVmNQTHpKa2diTnlKR0M4NjhxWkRrT0JscEdDZlVEV1daKzJKZzZWb1FLaCtoWWVGZG0iLCJtYWMiOiIyMmI1NzMyZTdiZjI3ZmM0MGQwODE2YzM3ZjU2YjMxZjg4MmNmMjE3OGIzYzg0YzRlZDc4MTRiOTQ5OGExOWU0IiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6IitBYXBZMDNpeUJFY2ZKNmNmTUllSnc9PSIsInZhbHVlIjoiSCtFNzlsdVBUVzUyR0dhQzBaalBDNWxqOUd6SnNnblNFY2xQcmJjeThLMm1tcE5UVEE3NEtMMDVWT2JzMUhJL014cSs1aThxdE90aHpqTW5MVlZuaW41OUhyQXp4NmFXMHRnRVowZDVSbGxFKy9NZ3FuUFpMQlh1Y3dTZkkvSDYiLCJtYWMiOiI4MjJjZDRmZjkyNTQ0YWYwOTgzOTFjYmExZTQ5YzEyZmM4MzY0NmUyYjAyYTU4OGIzMWI5NWVhYWVhMjQ1YTA2IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjNXWktvcElBVG5GN0pXc21tcUdUd0E9PSIsInZhbHVlIjoiMkl3N1BVT29hVHArNGdtYmpSekJrcFJxTWVaeEgxaXZ3V0lHTnNSeXRyeUcvbGQ0TTZnSDd6aGVtMkJ0NFdicCIs" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "gj0DKypQs0BYbHQ1oqjIuuoEke43LacflyFw3kfl" "uc_cart_id" => "8b2782f5bed06b572c7aaf42680df52a" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/16228" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:20:48GET/chapter/162281121910