Topics in Anti-Cancer Research

Volume: 10

Targeting Cancer-Specific Inflammatory Components In Cancer Therapeutics

Author(s): V. Veena*, Pravallika Mandlipalli and A Harikrishnan * .

Pp: 50-67 (18)

DOI: 10.2174/9789815039290121100006

* (Excluding Mailing and Handling)

Abstract

Cancer is a complicated family of diseases that causes major hurdles for global health. Several studies on cancer biology and cancer treatment strategies have revealed that cancer is highly genetically diverse and heterogenic in nature. The complexity of cancer is due to the highly inflammatory microenvironment which resembles wound healing process and highly acidic in nature. Hence, this condition is referred as cancer related inflammation (CRI) that drives the cancer resistance and subsequent recurrence of cancer after treatment. The major deregulated pathways associated with CRI are nuclear factor kappa B (NF-κB) and phosphoinositol-3-kinases (PI3-K) involved in cancer growth, proliferation, cancer cell survival and metastasis. Therefore, the protein factors of these pathways seem to be an attractive target for the molecular targetted therapy for cancer. However, efficient cancer treatment relies on the stages of cancer and the response to the treatment. Hence, cancer specific inflammatory components are the major targets for drug discovery, development and associated clinical trials.


Keywords: Anti-inflammatory, Cancer related inflammation, Cancer treatment, Cancer imaging, Cytotoxicity, Molecular target, Mitochondrial targeting, Photoreactive, Targeted therapy.

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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51364601 and j.to_ip >=51364601 )) and ((j.from_date <= 1739988810 and j.to_date >= 1739988810 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16048) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51364601 and j.to_ip >=51364601 )) and ((j.from_date <= 1739988810 and j.to_date >= 1739988810 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16048) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51364601 and j.to_ip >=51364601 )) and ((j.from_date <= 1739988810 and j.to_date >= 1739988810 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16048)
      540μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3163 and `b`.`banner_from_date` <= 1739988810 and `b`.`banner_to_date` >= 1739988810 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3163
      • 3: 1739988810
      • 4: 1739988810
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='f1eacf1aa3f5885d8a2d781f628db42e'
      200μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    9Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        znujrspxFHiivGetlr0qmfwmDLIbwTITGLZ5CCa6
        uc_cart_id
        f1eacf1aa3f5885d8a2d781f628db42e
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/16048" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/16048
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjVYZzVSQW51WnhGTENScmRMc3FGSkE9PSIsInZhbHVlIjoiZU8yVURaQmN2SkJTVjVRdXlzVWcxKzdNL0RoMHN0Z2pZNUZTMCswaUNDOD0iLCJtYWMiOiI4NjdlOTRjZDg5YjAzMWU5YTRhMzIwZGYxNTliYmJiOWNmZDc4OWIxOGNkZGU4NjkyYjM0ZmM3OWM1YmJhOWM1IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjVYZzVSQW51WnhGTENScmRMc3FGSkE9PSIsInZhbHVlIjoiZU8yVURaQmN2SkJTVjVRdXlzVWcxKzdNL0RoMHN0Z2pZNUZTMCswaUNDOD0iLCJtYWMiOiI4NjdlOTRjZDg5YjAz" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:13:30 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkZwd0lFVldSSVZRdFBpb2xwcEh1YVE9PSIsInZhbHVlIjoid1RCU1ZoRjVYdUZWc1pwNHovQmViVEhhSDJKVUJsekgyclRiQ0h0OGEyL3ZDM0E5WXpSQkxhYVc0bklXL3FUK3diZEs3TXhobXdjR0xSWEs0SzRWTHNseGdYSnlVSTJzVmVFbXJ2MXBEaE9xNWNadG5uNmRUSXBoNVc2ZnFEQnIiLCJtYWMiOiIxZTY2N2MxNjc5YTkxZjUzMmNjYjJiZDZlYjZmMDcxMzMzYTI4ODU3OTBmM2EwNjRmMjUyMDI2NjdkZDJhODBkIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:13:30 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkZwd0lFVldSSVZRdFBpb2xwcEh1YVE9PSIsInZhbHVlIjoid1RCU1ZoRjVYdUZWc1pwNHovQmViVEhhSDJKVUJsekgyclRiQ0h0OGEyL3ZDM0E5WXpSQkxhYVc0bklXL3FUK3diZEs3T" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ino0VHlyNUxuc0NEc3VpVUJWdUZLMnc9PSIsInZhbHVlIjoieGJkZ0I5OHBvTzVUSjJiRDY0c0h4YjZYeEV4RTZ4NldWQzdiYnU0TVlneGcrNUpPZHlvUFF3ZnBiTzNPNFcrY1hGb2lVQm0zK2FsVVNDdjM3VEFCRngraERwRU5vbERVdTVaWGtGa05SZmt5dmQ4VEphNjAyUTkzREZHc2NwajYiLCJtYWMiOiJkOTMwYjEzMmM2YzQxYTRiZWNmMzdmYWYzN2RjYWM5YTJjOWIyNjhjMGFmMGY5MmU3ZThhNzc1MThmMjhkYWQ5IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ino0VHlyNUxuc0NEc3VpVUJWdUZLMnc9PSIsInZhbHVlIjoieGJkZ0I5OHBvTzVUSjJiRDY0c0h4YjZYeEV4RTZ4NldWQzdiYnU0TVlneGcrNUpPZHlvUFF3ZnB" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkZwd0lFVldSSVZRdFBpb2xwcEh1YVE9PSIsInZhbHVlIjoid1RCU1ZoRjVYdUZWc1pwNHovQmViVEhhSDJKVUJsekgyclRiQ0h0OGEyL3ZDM0E5WXpSQkxhYVc0bklXL3FUK3diZEs3TXhobXdjR0xSWEs0SzRWTHNseGdYSnlVSTJzVmVFbXJ2MXBEaE9xNWNadG5uNmRUSXBoNVc2ZnFEQnIiLCJtYWMiOiIxZTY2N2MxNjc5YTkxZjUzMmNjYjJiZDZlYjZmMDcxMzMzYTI4ODU3OTBmM2EwNjRmMjUyMDI2NjdkZDJhODBkIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:13:30 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkZwd0lFVldSSVZRdFBpb2xwcEh1YVE9PSIsInZhbHVlIjoid1RCU1ZoRjVYdUZWc1pwNHovQmViVEhhSDJKVUJsekgyclRiQ0h0OGEyL3ZDM0E5WXpSQkxhYVc0bklXL3FUK3diZEs3T" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ino0VHlyNUxuc0NEc3VpVUJWdUZLMnc9PSIsInZhbHVlIjoieGJkZ0I5OHBvTzVUSjJiRDY0c0h4YjZYeEV4RTZ4NldWQzdiYnU0TVlneGcrNUpPZHlvUFF3ZnBiTzNPNFcrY1hGb2lVQm0zK2FsVVNDdjM3VEFCRngraERwRU5vbERVdTVaWGtGa05SZmt5dmQ4VEphNjAyUTkzREZHc2NwajYiLCJtYWMiOiJkOTMwYjEzMmM2YzQxYTRiZWNmMzdmYWYzN2RjYWM5YTJjOWIyNjhjMGFmMGY5MmU3ZThhNzc1MThmMjhkYWQ5IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ino0VHlyNUxuc0NEc3VpVUJWdUZLMnc9PSIsInZhbHVlIjoieGJkZ0I5OHBvTzVUSjJiRDY0c0h4YjZYeEV4RTZ4NldWQzdiYnU0TVlneGcrNUpPZHlvUFF3ZnB" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "znujrspxFHiivGetlr0qmfwmDLIbwTITGLZ5CCa6" "uc_cart_id" => "f1eacf1aa3f5885d8a2d781f628db42e" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/16048" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:13:30GET/chapter/160481121911