Chalcones as Anti-inflammatory, Anti-diabetic, and Anti-depressant Agents

Abstract

Flavonoids are naturally sourced compounds found in many substances consumed as food and have beneficial effects on human health. Chalcones, essential members of the flavonoid family, have also attracted many researchers' attention due to their wide range of pharmacological effects. In this chapter, the antiinflammatory, antidiabetic, and antidepressant activities of the natural compounds in the structure of chalcones and the compounds synthesized with the help these compounds will be discussed. It has been written after a literature review of the articles published between 2000 and 2020 and aims to be a guide for designing new active drug ingredients.

Keywords: Aldose reductase, Alpha glucosidase, Antidepressant, Antidiabetic, Antiinflammatory, Butein, Chalcones, Cyclooxygenase, Dipeptidyl peptidase-IV, Heme oxygenase-1, Interleukins, Isoliquiritigenin, Kinases, 5-Lipoxygenase, Monoamine oxidase, Noradrenalin, Protein tyrosine phosphatase 1B, Serotonin, Sodium-glucose cotransporter 2, Tumour necrosis factor-alpha.