Quick Guideline for Computational Drug Design (Revised Edition)

Secondary Structure Analyses

Author(s): Sheikh Arslan Sehgal*, Rana Adnan Tahir and Muhammad Waqas

Pp: 17-20 (4)

DOI: 10.2174/9789814998697121010006

* (Excluding Mailing and Handling)

Abstract

The analyses of a secondary structure of protein always show logical insights for further studies. α-helices and β-sheets are considered as the major elements of secondary structure, which are based on hydrogen bond donor and acceptor residues interactions. The secondary elements may provide information regarding the behavior of the proteins. ProFunc tool was utilized to analyze the secondary structure of PSEN2.


Keywords: Helices, Motifs, ProFunc, Secondary structure, Sheets.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 58953283 and j.to_ip >=58953283 )) and ((j.from_date <= 1739834704 and j.to_date >= 1739834704 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 15439) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 58953283 and j.to_ip >=58953283 )) and ((j.from_date <= 1739834704 and j.to_date >= 1739834704 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 15439) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 58953283 and j.to_ip >=58953283 )) and ((j.from_date <= 1739834704 and j.to_date >= 1739834704 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 15439)
      520μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3116 and `b`.`banner_from_date` <= 1739834704 and `b`.`banner_to_date` >= 1739834704 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3116
      • 3: 1739834704
      • 4: 1739834704
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='bf4f8487f3df37d0cdb9c184e15159c6'
      180μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    5Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        bYxwOffiw8XYqUMmCm2NmFur2CFFuFWYvrMaRiTn
        uc_cart_id
        bf4f8487f3df37d0cdb9c184e15159c6
        _previous
        array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/15439" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/15439
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjVtdjdWTzRXay8yN3VycEZHNEVpT0E9PSIsInZhbHVlIjoiQkNZczNTVURqQkUyT2hCdDJnOXdHdXpkZGdrUlRRTVdRYjNQYzNueC92Zz0iLCJtYWMiOiI5NjM5Nzg2NzFmZTYwYzE1MGRmYzIyMjc2ZmMzMWZlM2M5YmQ5MzI4NWNjOTk5NDAyOTUyMWVlMTFjZWIwYTk0IiwidGFnIjoiIn0%3D; XSRF-TOKEN=eyJpdiI6Ikt0WEZSK0pnMUQ3am55TGVsT0xYYkE9PSIsInZhbHVlIjoiRlZLVzZyak1weXdIRUpsck9wMVp2dzVJbEo4anh0T3Q3QmlzWHgzelQzMk1IbGhLK3lJbmU1L1hPZU1sUnE5K2krRkVuQUVSVElBSnRiYTFGRlh2dEdkUEZ6WTVSeHhlNnIwZHI4SldVUXlsZkNxVGxJTS9nS0hlZ3dnUkQxaDIiLCJtYWMiOiI4Njk4YjJmMDBmMjk0NDNhMWNmMDQ5YjI5YzBlN2IwNzkyNWYzODlkMjA5ODlkYjdkMDkyZDU2MmEyNDg1YzEyIiwidGFnIjoiIn0%3D; alphaeurekaselectnet_session=eyJpdiI6IkpmWkNFTy9aRGZTSStNTWFYQWFVenc9PSIsInZhbHVlIjoiREtzSXU5WTFXbW1wUDdVbExreS83SVN0aDlLaHdNNXpuTjgwUExjbHF2YWFaS1dKVUNvREtKNFk4d2JlU3JKMkNmNEdsVUM1dUhRNm44S2NEQ25zNVU0Z0lENDlsdUJyaTJZbkJXbG9aTUdVZmQ5cWFNZ056SWMwRktQZHQyZkQiLCJtYWMiOiI2NzhkYTZkNjdkOTJhNGYxNThkZGIwYjUyMDUzOGMyOWE1ZjY2OTFhYzY5OTQwNDE3NTkxMzFiMThhMzNlODgyIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjVtdjdWTzRXay8yN3VycEZHNEVpT0E9PSIsInZhbHVlIjoiQkNZczNTVURqQkUyT2hCdDJnOXdHdXpkZGdrUlRRTVdRYjNQYzNueC92Zz0iLCJtYWMiOiI5NjM5Nzg2NzFmZTYw" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
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        response_headers
        0 of 0
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        session_attributes
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        array:5 [ "_token" => "bYxwOffiw8XYqUMmCm2NmFur2CFFuFWYvrMaRiTn" "uc_cart_id" => "bf4f8487f3df37d0cdb9c184e15159c6" "_previous" => array:1 [ "url" => "https://alpha.eurekaselect.com/chapter/15439" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:25:04GET/chapter/15439112197