Abstract
The heart of adult humans is usually less capable of regeneration; several strategies have been used for the repairment of a damaged heart and to recover its function. However, stem cell technology showed a promising approach for cardiac therapy. More advanced strategies are used for improved stem cell-mediated cardiac regenerative therapy and to develop vascularization between scaffold (established by 3D engineered techniques) and host hearts. Through understanding the cellular and molecular mechanisms regulating heart regeneration, considerable progress has been made, which offers potentiality in controlling cardiac remodeling and redirecting the adult human heart towards a regenerative state.
Keywords: Cardiac regeneration, Cardiomyocytes, Mesenchymal stem cells, Pluripotent stem cells, Scaffold.
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